Bovine acylated ghrelin,AG ELISA Kit
- Known as:
- Bovine acylated ghrelin,AG Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- BA0051
- Product Quantity:
- 96T
- Category:
- -
- Supplier:
- Meretciel
- Gene target:
- Bovine acylated ghrelin ELISA Kit
Related genes to: Bovine acylated ghrelin,AG ELISA Kit
- Gene:
- GHRL NIH gene
- Name:
- ghrelin and obestatin prepropeptide
- Previous symbol:
- -
- Synonyms:
- MTLRP, ghrelin, obestatin
- Chromosome:
- 3p25.3
- Locus Type:
- gene with protein product
- Date approved:
- 2006-01-05
- Date modifiied:
- 2016-08-10
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- Low temperature is an important environmental factor influencing the phenotypic plasticity of the gastrointestinal (GI) tract. However, it remains unclear how GI activity is regulated to cope with low temperature stress. The Daurian ground squirrel (Spermophilus dauricus) is a typical hibernator, which exhibits tolerance to low temperature.This study investigated the expression of hypothalamic appetite-regulating factors and GI activity-regulating factors in ground squirrels exposed to low temperature. The results showed that after continuous low temperature exposure (5 ± 1 °C for 6 days), the immunoreactive expression of c-Fos and neuronal nitric oxide synthase (nNOS) was significantly increased in the arcuate nucleus (ARC), dorsomedial hypothalamic nucleus (DMH), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN); the neuropeptide Y (NPY) expression was upregulated in the ARC, LHA, and PVN. The mRNA expression of gastric nNOS, NPY, CHRM2, HTR4, ADRB2 and GHRL was significantly downregulated under low temperature. Correspondingly, the protein expression of M2mAChR, 5-HT4R, and ADRB2 was decreased, whereas expression of nNOS and GHRL was increased. In the jejunum, the mRNA expression of the above genes, as well as the protein expression of nNOS, M2mAChR, 5-HT4R, ADRB2, and GHRL, was elevated. These results indicate that low temperature stress can significantly activate hypothalamic neural circuits involved in appetite and motility regulation, while suppressing gastric gene expression and activating intestinal gene expression, which likely modulates gastric emptying and enhances intestinal function, enabling the ground squirrel to meet basal energy requirements under short-term low temperature stress, reflecting the remarkable plasticity of the GI tract. - Source: PubMed
Publication date: 2026/05/22
Ju Xiang-YaoMa Yong-PingWang Jian-Li - Obesity is a multifactorial disease characterized by an excessive and abnormal accumulation of body fat that results from both genetic and environmental factors. In this review, we revisited the literature on the variability of obesity-associated genes and their impact on the effectiveness of obesity treatment interventions. Individuals harboring variants of these genes were found to have either better or worse outcomes after weight loss therapies. The majority of the genetic variants were identified in genes that play a role in the leptin-melanocortin pathway (LEPR, NPY, POMC, MC4R, GHRL, GHSR, GLP-1R, BDNF), which regulates food intake and energy expenditure. Both these processes are key elements for energy homeostasis, therefore relevant for the success/failure of weight loss strategies. Some genetic alterations were found to modulate the outcomes of different weight loss interventions, while others were only linked to the effectiveness of bariatric surgery, according to the studies here included and available. Herein, we revisited the most relevant molecular data, with a primarily focus on human studies, concerning how the genetic background influences the outcomes of weight loss interventions. Our aim is to gather relevant information on the genetic data related to weight loss strategies that can be compelling to guide clinical decisions, setting realistic expectations, and ultimately improving the long-term health conditions of individuals with obesity. - Source: PubMed
Publication date: 2026/04/28
Santos-Pereira MarianaGuimarães MartaMonteiro Mariana PPereira Sofia SAzevedo Luísa - This study explored protein expression in B-cell acute lymphoblastic leukemia (B-ALL) patients with and without elevated weight or obesity and controls to understand global proteomic differences between newly diagnosed B-ALL patients and controls as well as the influences of elevated body mass index (BMI) on pretreatment inflammatory and immune-related protein expression in B-ALL patients. Protein expression was measured in serum samples of pediatric patients (aged 1-21 years) with newly diagnosed B-ALL ( = 39), and age and sex-matched controls ( = 41) using OLink panels. We examined normalized protein expression data clustered by patient information in -unsupervised hierarchical clustering and principal component analysis. Of 239 assays, 128 assays differed significantly based on B-ALL diagnosis and 4 assays (APLP1, CDHR5, GHRL, SEZ6L) varied significantly as a function of BMI. In healthy individuals, oncology marker furin (p.adjust = 0.016) was more highly expressed in the high-BMI category; this trend was reversed for B-ALL individuals. Furin expression is often upregulated in malignancies and obesity; however this suggests its expression may follow unique patterns in pediatric B- ALL patients with elevated BMI. - Source: PubMed
Publication date: 2026/04/28
Werk Rachel SChacón Jeremy MTurcotte Lucie MRyder Justin R - Genes play a pivotal role in appetite regulation and energy homeostasis during a person's obesity. LEP (Leptin) and POMC (Proopiomelanocortin) are vital for appetite suppression and promoting satiety, while AgRP (Agouti-related peptide) and NPY (Neuropeptide Y) serve to stimulate appetite, creating a balanced interplay between hunger and satiety signals. GHRL (Ghrelin) further promotes hunger, emphasizing the complexity of these regulatory mechanisms. BDNF (Brain-derived neurotrophic factor) shows a dual role, impacting energy homeostasis not only in the brain but also in adipose tissue, thereby influencing lipid metabolism. PCSK1 (Proprotein Convertase Subtilisin/Kexin Type 1) is critical for the processing of neuropeptides that modulate energy balance. IGF2BP2 (Insulin-like Growth Factor 2 mRNA-Binding Protein 2) and MAP2K5 (Mitogen-Activated Protein Kinase 5) contribute to metabolic processes involved in fat accumulation and glucose regulation. Thus, emphasizing the significance of these mechanisms offers valuable insights that could lead to effective interventions for obesity prevention and management. - Source: PubMed
Kaur HarmandeepKaushik DeepikaRasane PrasadOz FatihProestos CharalamposKumar Mukul - The synchronization of biological rhythms to environmental cues is essential for maintaining temporal homeostasis. However, the specific neuroendocrine and metabolic effects of circadian misalignment in fish remain poorly understood. This study investigated the effects of chronodisruption on energy homeostasis in goldfish (Carassius auratus). Fish were exposed for 53 days to three conditions: Control (12L:12D photoperiod, feeding at ZT 1); Random Feeding (RF; 12L:12D, feeding at random times) and continuous light (LL, feeding at ZT 1). Feed intake, metabolic rate, and locomotor activity were monitored as indicators of energy input and expenditure. Biometric indices (weight and length gain, growth, nutritional and hepatosomatic indices) were calculated. The expression of feeding and growth regulating genes was also analyzed in hypothalamus (hcrt, npy, crh, pomca, cartpt1, and cartpt2), telencephalon (cnr1), liver (igf1, and lepa1), and intestine (cck1 and ghrl). Plasma and liver metabolites (triglycerides, glycogen, lactate, and glucose) and plasma cortisol levels were analyzed to assess metabolic and stress responses. Both RF and LL groups showed elevated metabolic rate and feed intake, accompanied by changes in the expression of feeding regulators that favored orexigenic signals. However, only RF fish showed increased growth, weight, hepatosomatic index, and plasma glucose, suggesting a positive energy balance. LL fish showed growth similar to controls, likely due to a greater increase in energy expenditure. Overall, our results show that disruption of temporal feeding or light cues alters energy balance, with different physiological outcomes depending on the type of disruption. This study highlights the critical role of circadian alignment in maintaining energy homeostasis in goldfish. - Source: PubMed
Publication date: 2026/04/24
Saiz NuriaIsorna EstherHerrera-Castillo LisbethDelgado María JesúsRuiz-Jarabo Ignaciode Pedro Nuria