Recombinant Ubiquitin HUMAN
- Known as:
- Recombinant Ubiquitin HUMAN
- Catalog number:
- REP0014
- Product Quantity:
- 500ug
- Category:
- -
- Supplier:
- DIATHEVA
- Gene target:
- Recombinant Ubiquitin HUMAN
Related genes to: Recombinant Ubiquitin HUMAN
- Gene:
- JAK3 NIH gene
- Name:
- Janus kinase 3
- Previous symbol:
- -
- Synonyms:
- L-JAK, JAKL, LJAK, JAK3_HUMAN, JAK-3
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-19
- Date modifiied:
- 2019-04-23
Related products to: Recombinant Ubiquitin HUMAN
Related articles to: Recombinant Ubiquitin HUMAN
- Luteolin is a naturally occurring flavone known to modulate cellular redox balance and inflammatory signaling; however, its role in integrated redox-inflammatory responses remains incompletely defined. The present study investigated the effects of luteolin, alone and in combination with the selective JAK1 inhibitor upadacitinib, on oxidative stress parameters, inflammatory mediators, and JAK/STAT-related gene expression in human breast (MCF-7), colorectal (HT-29), and hepatocellular (HepG2) cancer cell lines, with L929 fibroblasts as a non-tumor comparator. - Source: PubMed
Publication date: 2026/07/03
Sezgin Ayşe KoçakGündüz Meliha KoldemirAydın ElifKaymak Güllü - Guomin Decoction (GMD) is a traditional Chinese medicine formula that has been empirically used for the treatment of inflammatory skin disorders, including psoriasis. However, its active constituents and underlying mechanisms remain poorly defined. Gomisin G (GomG), a representative bioactive component of GMD, possesses potent anti-inflammatory properties; yet, its role in psoriasis has not been established. - Source: PubMed
Publication date: 2026/06/30
Yang HuiTao ChunyanLi XiaotingZhang YunLi YingtaoDong RongjingLi SisiQu Lu - Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive molecular complexity, profound stromal remodeling, and limited responsiveness to systemic therapies. Although gemcitabine-based regimens remain widely utilized, the molecular pathways that influence treatment-associated biological variation are incompletely understood. The TGFβ and JAK/STAT signaling networks are recognized regulators of tumor progression, immune modulation, and therapeutic resistance; however, their genomic architecture in clinically stratified PDAC populations remains poorly defined. - Source: PubMed
Publication date: 2026/06/12
Diaz Fernando CWaldrup BrigetteCarranza Francisco GManjarrez SophiaVelazquez-Villarreal Enrique - - Source: PubMed
Publication date: 2026/06/18
King BrettSoung JenniferTziotzios ChristosRudnicka LidiaJoly PascalGooderham MelindaSinclair RodneyMesinkovska Natasha APaul CarleGong YankunAnway Susan DTran HelenWolk RobertZwillich Samuel HLejeune Alexandre - Pink lotus ( Gaertn.) contains bioactive flavonoids and alkaloids that exert anti-inflammatory and antioxidant activities, and inhibit TNF-α, IL-1β, IL-6 and NF-κB signaling pathways implicated in the pathogenesis of psoriasis. However, the effects of pink lotus flower oil (PLO) on psoriasis-like skin inflammation remain unexplored. Therefore, the present study aimed to evaluate the effects of PLO treatment on imiquimod (IMQ)-induced psoriasis-like skin inflammation in a mouse model. Briefly, BALB/c mice with IMQ-induced psoriasis were administered PLO (100 and 200 mg/kg), and the psoriasis area and severity index were measured. Histopathology, proinflammatory cytokine levels, antioxidant gene expression, oxidative stress and antioxidant marker levels, and immunoreactivity were also assessed. PLO treatment markedly reduced erythema, scaling and epidermal thickening, and suppressed keratinocyte proliferation, as evidenced by decreased proliferating cell nuclear antigen immunoreactivity, and downregulated mRNA levels of keratin-encoding genes 6 (), and . Moreover, PLO significantly downregulated the levels of proinflammatory cytokines, including TNF-α, IL-17A, IL-23 and , and reduced the infiltration of CD4 and mast cells. Mechanistically, PLO treatment decreased phosphorylated (p)-JAK2, p-JAK3 and p-STAT3 immunoreactivity by inhibiting JAK2/JAK3/STAT3 signaling. Oxidative stress was attenuated, as evidenced by reduced malondialdehyde levels, and increased nuclear factor erythroid 2-related factor 2, Cu/Zn-superoxide dismutase (), , catalase and glutathione peroxidase mRNA expression levels. PLO treatment also mitigated IMQ-induced splenomegaly, and suppressed expression in the spleen, and reduced expression in the axillary lymph nodes. In conclusion, PLO treatment ameliorated IMQ-induced psoriasis by enhancing antioxidant defenses, and by inhibiting JAK2 and JAK3/STAT3 signaling, supporting its potential as a therapeutic candidate for psoriasis. - Source: PubMed
Publication date: 2026/06/03
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