Recombinant Ubiquitin HUMAN
- Known as:
- Recombinant Ubiquitin HUMAN
- Catalog number:
- REP0014
- Product Quantity:
- 500ug
- Category:
- -
- Supplier:
- DIATHEVA
- Gene target:
- Recombinant Ubiquitin HUMAN
Related genes to: Recombinant Ubiquitin HUMAN
- Gene:
- JAK3 NIH gene
- Name:
- Janus kinase 3
- Previous symbol:
- -
- Synonyms:
- L-JAK, JAKL, LJAK, JAK3_HUMAN, JAK-3
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-19
- Date modifiied:
- 2019-04-23
Related products to: Recombinant Ubiquitin HUMAN
Related articles to: Recombinant Ubiquitin HUMAN
- Phospholipase C (PLC)-evoked rising intracellular Ca2+-levels are a prerequisite for platelet activation with subsequent thrombosis. The protein-tyrosine kinase Janus kinase 3 (JAK3) regulates phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-levels in platelets, thus significantly mediating activation-dependent platelet function and arterial thrombosis. - Source: PubMed
Publication date: 2026/09/21
Münzer PatrickKollotzek FerdinandManke Mailin-ChristinFindik BetülMott KristinaFischer MelinaLingens Gundula DZdanyte MonikaStein FredericGeue SaschaWalker BrittaGawaz MeinradGeisler TobiasRath DominikAhrends RobertLämmerhofer MichaelSchulze HaraldSkokowa JuliaBorst Oliver - The chronic failure of psoriasis treatment strongly recommends a tailored biocompatible therapeutic platform considering the immunological and inflammatory factors of psoriasis pathogenesis. This strategy recommends the utilization of natural phytomolecule of piceatannol due to its healing cutaneous potential, mesenchymal Stem cell-derived exosomes as a regenerative natural nanocarriers and a hydrogel facilitating prolonged release. This work aimed to augment the anti-psoriatic pattern of piceatannol utilizing the mesenchymal stem cells derived exosomes via topical delivery to imiquimod-induced psoriatic mice skin. The formulated exosomal piceatannol platforms were assayed for particle size analysis, entrapment efficiency, flow cytometry analysis, functional size of 137.6 nm, zeta potential of -61.4 ± 6.04 mV, PDI of 0.331, >97% positive expression of all the three tetraspanin markers (CD9, CD63, CD81), entrapment efficiency of 32.8 ± 1.7%, prolonged cumulative release reaching 37.5% after 72 h and satisfactory characterization of 2% w/w carboxymethylcellulose hydrogel. In vivo experimental estimation of the anti-psoriatic activity was conducted and supported by molecular analysis of IL-17, TNF-α, and pSTAT3 levels. mRNA expression of JAK3 was analyzed to explore the targeting of Janus kinase/STAT3. The findings revealed the promising anti-psoriatic activity of the exosomal piceatannol, supported by molecular potential in reducing the mentioned cytokine levels, targeting of JAK/STAT3 pathway and histopathological healing pattern in the psoriasis-induced skin. In conclusion, piceatannol was successfully shown to have a promising regenerative anti-psoriatic profile when loaded as an exosomal hydrogel. - Source: PubMed
Publication date: 2026/09/18
Al-Sawahli MajidAl-Zurfi Atheer Mohammed JasimHussein Ameen Ayad AAbdallah Ahmed NAlamoudi Jawaher AbdullahSaleh AsmaaEl-Telbany RaniaSalahuddin AhmadAlfaifi Mohammad YShati Ali AElbehairi Serag Eldin IKassem Amira BGalal Asmaa FKishta Mohamed SAlamri Zaenah ZuhairZakaria SherinNoreddin Ayman MEl-Telbany Dalia Farag AAbass Shimaa A - Rosacea is a chronic inflammatory skin disorder characterized by neurovascular instability and dysregulated innate immunity. Although mast-cell activation is increasingly recognized as a central pathogenic feature, the neuroimmune mechanisms linking neuropeptide signaling to mast cell-mediated inflammation remain incompletely defined. This study investigated whether calcitonin gene-related peptide (CGRP) promotes mast cell-mediated inflammation in rosacea and explored the underlying signaling mechanism. - Source: PubMed
Publication date: 2026/09/02
Li XiaojinFan HuipingSun RuiMa QingsongLiu JiayunLiu ChengqiZhang DongMa Weiyuan - Emerging evidence highlights the role of the gut microbiota in allergic asthma, with microbial metabolites mediating distal immune responses. This study investigated the protective efficacy of Lactiplantibacillus plantarum GUANKE and the mechanisms associated with dendritic cell (DC)-driven allergic airway inflammation (AAI). GUANKE conferred both prophylactic and therapeutic protection by attenuating airway hyperresponsiveness and Th2-driven inflammation while partially restoring regulatory T cell (Treg) population. Antibiotic depletion and fecal microbiota transfer indicated that GUANKE-mediated protection was associated with remodeling of the indigenous microbiota and microbiota-dependent restoration of circulating indole-3-acetic acid (IAA). Targeted serum metabolomics further revealed lower circulating IAA levels in patients with asthma than in healthy controls. Exogenous IAA reduced CX3CR1Ly6C monocytic precursors and pulmonary CD11b DC accumulation. These reductions were preserved after CD11c-specific aryl hydrocarbon receptor (AhR) deletion and accompanied by reduced JAK3-STAT3 signaling, lower STAT3 occupancy at the Jag1 promoter, and attenuation of the Jag1-Notch4-Hey1 axis. Pharmacological STAT3 activation or Jagged1-mediated Notch reactivation partially reversed the effects of IAA. Collectively, these findings link microbiota-associated IAA restoration to GUANKE-mediated protection and implicate STAT3-Jag1-Notch4 signaling in monocyte-to-DC differentiation during AAI. - Source: PubMed
Publication date: 2026/09/16
He YujiaMi JielanZhao ZhipingZhang XiaoYang ZhihanYue KunHuang YuanmingSong LiqiongWen XiaotingXu JianguoRen Zhihong - Soft tissue integration around implants is severely compromised by the inflammatory microenvironment, often leading to implant failure. However, due to the bioinert nature of titanium (Ti), effective strategies to regulate this microenvironment remain limited. Herein, we propose a poly(lipoic acid)-based antibacterial polymer (pLAP) enabling controlled molecular hydrogen (H) release to achieve both antibacterial and pro-regenerative effects for this critical challenge. The pLAP exhibits potent antibacterial activity, achieving killing efficiencies of 90.71% and 94.62% against Staphylococcus aureus and Porphyromonas gingivalis, respectively. Notably, the strong adhesion of pLAP to substrate and its affinity for bacterial membranes contribute to its durable and sustained antibacterial performance. Owing to the encapsulation of H-loaded TiO nanotubes within pLAP and its intrinsic biodegradability, a delayed and sustained H release profile is achieved, with H levels rising to 427 ppb within 24 h and persisting above 300 ppb for at least 72 h. In vitro and in vivo studies demonstrate that released H alleviates oxidative stress and modulates immune responses, with suppression of the JAK1-STAT1 and activation of the JAK3-STAT6 signaling pathways associated with these effects, promoting M2 polarization and enhancing soft tissue integration. Collectively, this work presents a robust and generalizable strategy for regulating the inflammatory microenvironment in peri-implantitis and other implant-associated inflammatory conditions. - Source: PubMed
Publication date: 2026/09/07
Hou ZishuoYuan YueLi GangfengPeng HaoweiWeng JienaWei HongboWang TengjiaoLi Peng