Polyclonal Rabbit ABCF2 Antibody
- Known as:
- Polyclonal Rabbit ABCF2 Antibody
- Catalog number:
- KA0049
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- KareBay
- Gene target:
- Polyclonal Rabbit ABCF2 Antibody
Related genes to: Polyclonal Rabbit ABCF2 Antibody
- Gene:
- ABCF2 NIH gene
- Name:
- ATP binding cassette subfamily F member 2
- Previous symbol:
- -
- Synonyms:
- EST133090, ABC28, M-ABC1, HUSSY-18
- Chromosome:
- 7q36.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-26
- Date modifiied:
- 2015-11-13
Related products to: Polyclonal Rabbit ABCF2 Antibody
Related articles to: Polyclonal Rabbit ABCF2 Antibody
- Nile tilapia (Oreochromis niloticus) is a widely farmed freshwater fish. Feeding with faba bean (Vicia faba L.) for 90-120 days can improve the muscle quality of tilapia. However, the underlying mechanism remain unclear. In the present study, tilapia were fed a faba bean-based diet for 120 days to induce muscle crisped, and ordinary tilapia fed a conventional diet were used as controls. Muscle histological characteristics were evaluated using hematoxylin and eosin staining, and transcriptome sequencing was conducted to explore molecular changes associated with the crisped muscle phenotype. The results showed that, as compared to ordinary tilapia, the fiber diameter and area were significantly reduced in crisped tilapia (p < 0.05), while the muscle fiber density was significantly increased (p < 0.05). In total, 576 differentially expressed genes (DEGs) were identified (FDR < 0.05), of which 211 were significantly up-regulated and 365 significantly down-regulated. Further analysis showed that DEGs associated with myofibroblast proliferation were up-regulated in crisped tilapia, while the glycolytic pathway was inhibited. The expression levels of muscle-related genes (i.e., actc1, myo7a, cib2, abcf2, and pfkfb2) were significantly higher in crisped tilapia than ordinary tilapia (p < 0.05), whereas the expression levels of gapdh, pgam2, eno3, and g6pi were significantly decreased (p < 0.05). Several DEGs and signaling pathways were identified. These findings provide transcriptomic evidence linking dietary faba bean feeding to muscle fiber remodeling and metabolic modulation in tilapia, offering a molecular basis for improving fillet quality through nutritional strategies. - Source: PubMed
Publication date: 2026/01/08
Li QingqingHuang YaoXie XiLiang ShaowenLin Li - Elexacaftor-tezacaftor-ivacaftor (ETI) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator that improves clinical outcomes in adolescents with cystic fibrosis. We aimed to investigate the effect of ETI on lung structural damage. - Source: PubMed
Publication date: 2025/10/22
Sermet-Gaudelus IsabelleLetierce AlexiaBerteloot LaurelineBonnel Anne-SophieChen YuxinMakani PunitKelly-Aubert MaireadKanoun FerielPenalva LucilleBouleghem NesrineBihouee TiphaineBui StéphanieCorvol HarrietHoudouin VéroniqueMittaine MarieTatopoulos AurelieWeiss LaurenceWizla NathalieKapel NathalieBessou AntoineTiddens H A W MCaudri DaanReix PhilippeMarguet Christophe - Symptoms of pudendal nerve neuropathy may overlap with various symptoms of interstitial cystitis (IC). As documented, there is a well-established correlation between the genes involved in ATP metabolism, neuropathy, and IC. ATP-binding cassette (ABC) transporters genes, in fact, are vital for ATP signaling. This study aims to associate the gene with a suspected pudendal nerve neuropathy and IC. - Source: PubMed
Publication date: 2025/02/26
Musumeci AntoninoVinci MirellaTreccarichi SimoneRagalmuto AldaBruno GiuseppeTinniriello GiordanaFarina JessicaFederico ConcettaSaccone SalvatoreCalì FrancescoPorru Daniele - Insecticide resistance is a major problem in food production, environmental sustainability, and human health. The cotton bollworm Helicoverpa armigera is a globally distributed crop pest affecting over 300 crop species. H. armigera has rapidly evolved insecticide resistance, making it one of the most damaging pests worldwide. Understanding the genetic basis of insecticide resistance provides insights to develop tools, such as molecular markers, that can be used to slow or prevent the evolution of resistance. We explore the genetic architecture of H. armigera resistance to a widely used insecticide, flubendiamide, using two complementary approaches: genome-wide association studies (GWAS) in wild-caught samples and quantitative trait locus (QTL) mapping in a controlled cross of susceptible and resistant laboratory strains. Both approaches identified one locus on chromosome 2, revealing two SNPs within 976 bp that can be used to monitor field resistance to flubendiamide. This was the only region identified using linkage mapping, though GWAS revealed additional sites associated with resistance. Other loci identified by GWAS in field populations contained known insecticide detoxification genes from the ATP-binding cassette family, ABCA1, ABCA3, ABCF2 and MDR1. Our findings revealed an oligogenic genetic architecture, contrasting previous reports of monogenic resistance associated with the ryanodine receptor. This work elucidates the genetic basis of rapidly evolving insecticide resistance and will contribute to developing effective insecticide resistance management strategies. - Source: PubMed
Publication date: 2025/01/29
Amado DouglasKoch Eva LCordeiro Erick M GAraújo Wellingson AGarcia Antonio A FHeckel David GMontejo-Kovacevich GabrielaNorth Henry LCorrêa Alberto SJiggins Chris DOmoto Celso - Multidrug resistance (MDR) poses one of the primary challenges for cancer treatment, especially in cases of metastatic disease. Various mechanisms contribute to MDR, including the overexpression of ATP-binding cassette (ABC) proteins. In this context, we reviewed the literature to establish a correlation between the overexpression of ABC proteins and MDR in cancer, considering both in vitro and clinical studies. Initially, we presented an overview of the seven subfamilies of ABC proteins, along with the subcellular localization of each protein. Subsequently, we identified a panel of 20 ABC proteins (ABCA1-3, ABCA7, ABCB1-2, ABCB4-6, ABCC1-5, ABCC10-11, ABCE1, ABCF2, ABCG1, and ABCG2) associated with MDR. We also emphasize the significance of drug sequestration by certain ABC proteins into intracellular compartments. Among the anticancer drugs linked to MDR, 29 were definitively identified as substrates for at least one of the three most crucial ABC transporters: ABCB1, ABCC1, and ABCG2. We further discussed that the most commonly used drugs in standard regimens for mainly breast cancer, lung cancer, and acute lymphoblastic leukemia could be subject to MDR mediated by ABC transporters. Collectively, these insights will aid in conducting new studies aimed at a deeper understanding of the clinical MDR mediated by ABC proteins and in designing more effective pharmacological treatments to enhance the objective response rate in cancer patients. - Source: PubMed
Publication date: 2024/11/20
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