Polyclonal Rabbit ARFGEF2 Antibody
- Known as:
- Polyclonal Rabbit ARFGEF2 Antibody
- Catalog number:
- KA0267
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- KareBay
- Gene target:
- Polyclonal Rabbit ARFGEF2 Antibody
Related genes to: Polyclonal Rabbit ARFGEF2 Antibody
- Gene:
- ARFGEF2 NIH gene
- Name:
- ADP ribosylation factor guanine nucleotide exchange factor 2
- Previous symbol:
- -
- Synonyms:
- BIG2
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-21
- Date modifiied:
- 2015-11-19
Related products to: Polyclonal Rabbit ARFGEF2 Antibody
Related articles to: Polyclonal Rabbit ARFGEF2 Antibody
- Type 2 diabetes (T2D) is a challenge for the healthcare system. It is a metabolic disease with increased blood sugar with severe complications when it becomes uncontrolled. These complications include diabetic nephropathy (DN), neuropathy, retinopathy neuropathy, and cardiovascular diseases (CVDs). T2D is induced by genetic, environmental, and lifestyle risk factors. Therefore, it is vital to distinguish between genetic risk loci for T2D and those that specifically predispose patients to DN, which may eventually facilitate personalized risk assessment and informed genetic counseling once these markers are clinically validated. The aim of this pilot study was to examine the candidate genes associated with DN using whole-exome sequencing (WES). - Source: PubMed
Publication date: 2026/03/26
Mir RashidElfaki ImadeldinAlmassabi Rehab FAlmowallad SanaaElnageeb Mohamed EMirghani Hyder OsmanAlbalawi WedAlbalawi Aziz DhaherAltemani Faisal HBarnawi JameelTayeb Faris JMoawadh MamdohBedaiwi Ruqaiah IAlanazi Mohammad A - AGEF-1, an ortholog of human ARFGEF1 and ARFGEF2, functions with ARF-1, ARF-5 and the AP-1 clathrin adaptor to regulate membrane trafficking. Similar phenotypes induced by the allele and suggested that was a hypomorph. Here we report that results in extrusion of yolk from the embryo. This is suppressed by RNAi of but not AP-1. Based on structure of the yeast AGEF-1 ortholog, Sec7p, the E1028K change is predicted to activate AGEF-1. We propose that Arf GTPase cycling is required to regulate trafficking with AP-1 but not with Arf effectors regulating yolk trafficking. - Source: PubMed
Publication date: 2026/02/11
FitzPatrick ClareSkorobogata OlgaFazlollahi Ali MGauthier Kimberley DRocheleau Christian E - - Source: PubMed
Publication date: 2025/09/10
Akçay NihalTosun DemetBingöl İlyas - In order to investigate the basic genetic structure of plumage colour in Jingyuan chicken and to explore the genetic markers for plumage colour development, the present study was carried out to investigate the candidate key SNPs and candidate genes regulating black, linen and white plumage and plumage traits of Jingyuan chicken by using selection signal analysis and genome-wide association analysis. Selection signal analyses showed that including 30, 40 and 18 overlapping genes were associated with black, linen and white plumage colours in Jingyuan chicken. Meanwhile, integrative genomic analyses identified BCAT1, LMO3, and PIK3C2G as primary candidates for black plumage, and IL1RAPL1 for white plumage, with all genes showing convergent support across multiple complementary approaches. Further screening through Fst and θπ values identified 10 key candidate genes significantly associated with plumage colour traits, including ARFGEF2, VPS37A, SNX12, KIT, MET, ROS1, CSF1R, NGF, CDC42, and TEK. These results provide a fundamental theoretical basis for the genetic structure and formation of Jingyuan chicken plumage. - Source: PubMed
Publication date: 2025/08/06
Yang LijuanZhao WeiChen SiyuXue LinTian JinliXu HairongZhang HaiboWang HuaGu YalingZhang Juan - Neural stem cells (NSCs) can self-renew and undergo differentiation via asymmetric division. Dysregulation in the balance between self-renewal and differentiation can lead to tumor formation or neurodevelopmental disorders. However, the regulation of phosphatidylinositol transfer protein (PITP)-dependent PI(4)P pools and myosin localization during asymmetric division in dividing cells is not well established. Here, we show that the Golgi proteins Arf1 and ARFGEF2/Sec71 control asymmetric division of NSCs by facilitating the localization of myosin II regulatory light chain, Sqh, to the NSC cortex. Arf1 can physically associate with Sqh and Vibrator, a type I PITP that stimulates phospholipid PI4K activity for PI(4)P production. Further, Arf1 and Sec71 facilitate PI(4)P localization to the cell cortex of neuroblasts. Our data provide evidence that the Golgi proteins Arf1 and its GEF Sec71 facilitate neuroblast polarity through phospholipid-dependent nonmuscle myosin II cortical localization. - Source: PubMed
Publication date: 2025/04/10
Gujar Mahekta RTan Ye SingGao YangWang Hongyan