Polyclonal Rabbit ALPK2 Antibody
- Known as:
- Polyclonal Rabbit ALPK2 Antibody
- Catalog number:
- KA0197
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- KareBay
- Gene target:
- Polyclonal Rabbit ALPK2 Antibody
Related genes to: Polyclonal Rabbit ALPK2 Antibody
- Gene:
- ALPK2 NIH gene
- Name:
- alpha kinase 2
- Previous symbol:
- -
- Synonyms:
- HAK
- Chromosome:
- 18q21.31-q21.32
- Locus Type:
- gene with protein product
- Date approved:
- 2004-12-01
- Date modifiied:
- 2018-02-13
Related products to: Polyclonal Rabbit ALPK2 Antibody
Related articles to: Polyclonal Rabbit ALPK2 Antibody
- To study a non-redundant role of Tcf12 in retinal health. - Source: PubMed
Yu TianUlker-Yilmazer GizemKirman Dogan CanTurpin Emily RYuksel SeherHe Yu-GuangLudwig SaraKumar AshwaniXing ChaoEvers BretMoresco Eva Marie YBeutler Bruce AAredo BogaleUfret-Vincenty Rafael L - Given the limitations of traditional indicators in evaluating the prognosis of endometrial cancer, this study identified the core genes related to prognosis, diagnosis, and treatment within the alpha-protein kinase (ALPK) family to address the lack of research on ALPK family genes in endometrial cancer. Using data from the TCGA database, we combined bioinformatics analyses (Cox regression, Kaplan-Meier analysis, GSVA enrichment, KEGG pathway analysis) and cell experiments (constructing ALPK2 knockdown/overexpression models; conducting clone formation assays; CCK-8 and other experiments), analysis of the associations among gene expression, prognosis, clinicopathological characteristics, and drug sensitivity was conducted. Only ALPK2 was identified as an independent risk factor for poor prognosis of endometrial cancer (HR > 1, P < 0.05). It was highly expressed in tumor tissues (P < 0.01) and associated with high-risk characteristics such as serous subtype and stage III/IV (P < 0.001). ALPK2 promoted tumor progression by regulating core processes such as proliferation and invasion, and pathways including ECM-receptor interaction and PI3K-Akt signaling. Its high expression was associated with resistance to cisplatin and paclitaxel, as well as sensitivity to olaparib (P < 0.01). Moreover, it demonstrated good diagnostic efficacy for stage III with an AUC of 0.872 and showed broad applicability. ALPK2 is a potential key molecule for prognostic assessment, diagnostic accuracy, and targeted therapy of endometrial cancer, providing a new basis for optimizing the diagnosis and treatment of this disease. - Source: PubMed
Publication date: 2026/05/04
Hu JuanShang AnquanWang HuiHan LeiGeng LeiMiao YongchangLu Chao - Transient receptor potential (TRP) ion channels of the melastatin family (TRPM) have eight members in mammals with a broad spectrum of functions. We investigated the evolution of this complex gene family across metazoans. The characteristic aminoterminal melastatin domain and the carboxyterminal NUDT9 homology domain with similarity to ADP-ribose pyrophosphatase were added to the common ancestor of TRPM and its sister channel TRPS. Gene duplications before the origin of bilaterians resulted in four TRPM genes: α, β, βlike, and γ. The two latter were discovered in this study. All four and TRPS are present in extant mollusks, while differential losses occurred in the other animal lineages. TRPS, TRPMβlike, and TRPMγ were lost in early chordates, meaning that the vertebrate ancestor started with TRPMα and β, both of which were duplicated before the first vertebrate tetraploidization 1R. The ancestor of the micro-RNA genes mir-211 and mir-204 was inserted in an intron of the ancestor of TRPM1/TRPM3. The TRPM6/TRPM7 ancestor acquired a kinase domain, probably a copy of the syntenic alpha protein kinase ALPK2/3 ancestor gene. Vertebrate 1R and gnathostome 2R together with local gene duplication and losses resulted in eight TRPM (TRPM1 to 8) in the gnathostome ancestor. In cyclostomes, extensive gene losses after the hexaploidization led to four TRPM. The teleost-specific tetraploidization 3R generated further TRPM ohnologs. The NUDT9 homology domain is retained in TRPM2 and TRPS but was lost repeatedly during TRPM evolution. Thus, the TRPM family displays considerable evolutionary variation with regard to gene and domain gains and losses. - Source: PubMed
Morini MarinaBergqvist ChristinaAsturiano Juan FDufour SylvieLarhammar Dan - Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration and loss of upper and lower motor neurons, with approximately 90% of cases being sporadic (sporadic ALS, SALS). A reliable diagnostic biomarker remains an unmet clinical need in SALS, with misdiagnosis and diagnostic delay hindering early management. The mislocalization of the RNA-binding protein TDP-43 (encoded by TARDBP), a pathological hallmark of SALS, could lead to aberrant splicing that produces transcripts with cryptic exons and, consequently, cryptic peptides. This study proposes cryptic peptides in serum extracellular vesicles as a novel candidate diagnostic biomarker of SALS. We included 10 healthy controls and 20 patients with SALS and quantified cryptic peptides predicted from cryptic exon sequences using mass spectrometry-based proteomics. Cryptic peptides from four proteins (RANBP1, IGLON5, ACTN1, ALPK2) were detected in participants, with the IGLON5 cryptic peptide detected significantly more frequently in SALS than in HC (adjusted P = 0.044). The number of detected cryptic peptides classified SALS and healthy controls with acceptable performance (area under the curve = 0.82). In conclusion, cryptic peptides could have diagnostic performance for SALS, warranting further validation. - Source: PubMed
Publication date: 2026/01/29
Takahashi KokiKato ChrisUeda KojiNakamura ShihoOzawa FumikoMoritoki NobukoShibata ShinsukeTakahashi ShinichiMorimoto SatoruOkano Hideyuki - Carcass composition traits, such as lean meat percentage, bone percentage, and number of ribs, are critical factors determining meat production and profitability of pigs. Traditional slaughter measurements are time-consuming, labor-intensive and invasive and cannot be evaluated on selection candidates. However, computed tomography scanning, a non-invasive technique, enables in vivo measurement of these traits, facilitating rapid accumulation of extensive phenotypic data. Despite these advances, the genetic mechanisms underlying computed tomography-based carcass traits remain largely unexplored. - Source: PubMed
Publication date: 2025/12/17
Han HeYu PengfeiZhang ZhenyangWei RanZhao WeiHou XiaoliangWang JianlanHe YongqiFu YanWang ZhenPan YuchunWang QishanZhang Zhe