Polyclonal Rabbit ADCY9 Antibody
- Known as:
- Polyclonal Rabbit ADCY9 Antibody
- Catalog number:
- KA0106
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- KareBay
- Gene target:
- Polyclonal Rabbit ADCY9 Antibody
Related genes to: Polyclonal Rabbit ADCY9 Antibody
- Gene:
- ADCY9 NIH gene
- Name:
- adenylate cyclase 9
- Previous symbol:
- -
- Synonyms:
- AC9
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-22
- Date modifiied:
- 2015-08-24
Related products to: Polyclonal Rabbit ADCY9 Antibody
Related articles to: Polyclonal Rabbit ADCY9 Antibody
- Nasopharyngeal carcinoma (NPC) is more common in certain geographic regions and populations and is frequently diagnosed at advanced stages, highlighting the importance of identifying factors associated with survival. - Source: PubMed
Chan Fu-ChunLin Zi-YangChang Kai-PingSu Wen-Hui - This study aimed to identify genomic regions and candidate genes associated with body composition and meat quality traits in Iberian pigs fattened in Montanera. A genome-wide association study (GWAS) was conducted on 528 pigs for 29 phenotypic traits using genomic data from the GGP Porcine HD Array. After quality control, 526 animals and 35,894 single nucleotide polymorphisms (SNPs) were retained for the association analysis. Despite the limitations of the genotyping chip used, which lacked coverage for Iberian-specific variants, the GWAS performed with genome-wide complex trait analysis (GCTA) software identified 165 SNPs significantly associated with 11 traits. Among these, 145 SNPs were clustered into 25 quantitative trait loci (QTL) regions. Five QTLs were identified for ham yield, containing genes such as KCNIP4, ZNF438, and PID1. Eight QTLs were associated with loin yield, with genes like PREX2, RSPO1, and PDE4B. One QTL was associated with shear force, and 16 QTLs were related to fatty acid composition. Genes linked to these traits included ELOVL6, associated with myristic and palmitic acids, and ADCY9 and ROBO1, associated with linoleic acid. Overall, these results provide novel genomic insights and markers that could enhance selection strategies in Iberian pig breeding programs, while highlighting the need for improved genomic tools tailored to local breeds. - Source: PubMed
Palma-Granados PatriciaGarcía-Casco Juan MRamón ManuelDelgado-Gutiérrez Miguel ASánchez-Esquiliche FernandoMárquez AlbertoMuñoz María - Circulating tumour cells (CTCs) provide a minimally invasive platform for disease monitoring and molecular profiling in colorectal carcinoma (CRC). This study aimed to identify prognostically relevant DNA methylation biomarkers and assess their translational potential in CTC-based liquid biopsy. Candidate CpG sites were first screened in silico using differential methylation analysis, LASSO regression, and Cox proportional hazards modelling based on The Cancer Genome Atlas-Colon Adenocarcinoma (TCGA-COAD) dataset, which included 430 tumour and 39 non-tumour colon mucosa samples. Three representative CpG sites (GPR125, GDNF, and ADCY9) were subsequently validated in an independent cohort of 62 CRC patients using quantitative methylation-specific polymerase chain reaction (PCR), with paired comparisons between CTCs and tumour tissues available in 32 cases. A five-CpG prognostic model derived from TCGA data was significantly associated with overall survival (hazard ratio = 4.23, p < 0.001), with time-dependent area under the curves (AUC)s of 0.718, 0.765, and 0.787 at 1, 3, and 5 years. In tumour tissues, GDNF methylation showed significant associations with age, tumour site, histological grade, T stage, and lymphovascular invasion, while GPR125 methylation was associated with lymphovascular invasion, and ADCY9 showed no significant clinicopathological correlations. Network analysis further identified GDNF as a distinct methylation module linked to multiple adverse pathological features. These findings suggest that DNA methylation biomarkers, particularly GDNF, are closely associated with tumour aggressiveness in CRC and support their potential application in both tissue-based assessment and CTC-driven molecular profiling. - Source: PubMed
Publication date: 2026/04/14
Chen ZhuoWoon Jun YuMoetamedirad NedaIslam Md SajedulVidanapathirana GihaniNurujjaman MdLu Cu TaiQiao BinGopalan VinodLam Alfred King-Yin - The greater amberjack () is a globally important aquaculture fish species belonging to the family Carangidae. However, current research on the ovarian development and regulation of the greater amberjack is limited, particularly with regard to early ovarian development in artificially bred individuals. Therefore, this study aims to analyze the ovarian transcriptomes at the primary growth stage in one-year-old fish at the chromatin nucleolar stage and two-year-old fish at the perinucleolar stage to suggest how early ovarian development takes place in artificially bred greater amberjacks. To do this, the study constructed ovarian mRNA expression profiles of different stages of artificially bred fish and identified differentially expressed genes (DEGs), Gene Ontology terms, and Kyoto Encyclopedia of Genes and Genomes pathways important for various physiological processes. A functional analysis revealed that the DEGs closely related to ovarian development were involved in cell growth and death (e.g., , , , , , and ), the TGF-beta signaling pathway (e.g., , , , , , and ), steroid hormone biosynthesis (e.g., , , and ), and the endocrine system (e.g., , , , and ). These findings suggest that ovarian development is the result of the coordinated regulation of various genes responsible for various functions. This study provides a theoretical basis for exploring the underlying molecular mechanisms of early ovarian development in artificially bred greater amberjacks. - Source: PubMed
Publication date: 2026/02/25
Deng QiuxiaHuang YangRu XiaoyingLin HaoyiYou XinxinHao RuijuanLi HangHu QinZhang DongyingZhao YanfeiWu JinhuiLi GuangliZhu Chunhua - , a crucial member of the adenylate cyclase family, exerts neuroprotective and analgesic effects in the nervous system by modulating the activity of the cAMP/AMPK signaling pathway. However, the role of the gene in neural regeneration remains unreported. In this study, we utilized , a highly regenerative planarian species, as a model to systematically examine the spatiotemporal expression pattern of the gene during planarian brain regeneration and investigate its regulatory function in this process. The results demonstrated that the downregulation of resulted in abnormal brain regeneration in planarians, characterized by partial loss of the nerve cord, reduced numbers of collateral branches, and significant inhibition of the regeneration and differentiation of multiple neuron types. RNA sequencing revealed that the downregulation of led to 499 differentially expressed genes, with KEGG enrichment pathway analysis indicating significant associations with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Double RNAi experiments demonstrated that simultaneous knockdown of and significantly restored neural regeneration. Collectively, might promote the comprehensive reconstruction of neural structure by hierarchically regulating the regeneration intensity through negative regulation of the downstream inhibitory factor . This study discloses the function of in planarian neural regeneration, providing a theoretical foundation for its application in investigating neural regeneration mechanisms and neurodegenerative disease pathogenesis in higher vertebrates. - Source: PubMed
Publication date: 2026/02/24
Wang XinruiHu SitongZhang RuijiaHan XinluGao LiliYang FengtangCao ZhonghongZhen Hui