Polyclonal Rabbit BAI1 Antibody
- Known as:
- Polyclonal Rabbit BAI1 Antibody
- Catalog number:
- KA0378
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- KareBay
- Gene target:
- Polyclonal Rabbit BAI1 Antibody
Related genes to: Polyclonal Rabbit BAI1 Antibody
- Gene:
- ADGRB1 NIH gene
- Name:
- adhesion G protein-coupled receptor B1
- Previous symbol:
- BAI1
- Synonyms:
- -
- Chromosome:
- 8q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-05
- Date modifiied:
- 2015-09-11
Related products to: Polyclonal Rabbit BAI1 Antibody
Related articles to: Polyclonal Rabbit BAI1 Antibody
- Lactation curve parameters (LCP) are essential in the refinement of dairy cattle breeding programs due to their relationship with the shape of lactation curves and their biological interpretations. In this context, the primary objectives of this study were to perform genome-wide association studies and functional enrichment analyses of various LCP from random regression models based on 3 nonlinear functions (Wood [WD], Wilmink [WL], and Ali-Schaeffer [AS]) in American Holstein cattle. We used 2,754,840 and 1,642,653 daily milk yield records of 11,139 first and 6,735 s parity cows, respectively, born between 2012 and 2019. A total of 14,464 animals were also genotyped with 60,277 single nucleotide polymorphisms (SNP). The SNP effects, the proportion of the total additive genetic variance explained by them, and their approximate P-values, were estimated for the random regression coefficients based on the GBLUP method. Significant SNP were identified using a modified Bonferroni multiple testing correction that accounts for the number of independent chromosomal segments. Genes and quantitative trait loci located within 100 kb upstream or downstream of the significant SNP were then examined, and functional enrichment analyses were conducted on the candidate genes identified for each LCP. For first parity cows, 81, 128, and 196 significant SNP were identified for the WD, WL, and AS parameters, respectively; whereas for second-parity cows, 120, 125, and 128 significant SNP were identified for the same parameters. The significant SNP were located on 18 autosomal chromosomes. One genomic region (BTA14: 1,801,116 bp) was common to all the parametric functions (WD, WL, and AS). The genomic markers located on BTA15 and BTA19 were unique to the WL parameters; whereas those located on BTA3 and BTA20 were unique to the AS parameters. There were significant SNP located on BTA14 capturing more than 1% of the total additive genetic variance. Twenty candidate genes (i.e., ARC, ADGRB1, C8orf90, CYP11B1, DENND3, GML, GPR20, JRK, LY6D, LY6E, LY6L, LYNX1, LYPD2, PSCA, PTK2, PTP4A3, SLURP1, SLC45A4, THEM6, and TSNARE1) were common to all the parametric functions. No significant gene ontology terms were found for the WD parameter c (i.e., decreasing slope parameter after the lactation peak yield) for first parity cows, and for the AS parameters d and f (parameters associated with the increasing slope) for second-parity cows. Previous reports have identified candidate genes within these genomic regions that possess biological functions related to apoptotic and regulation of gene expression, milk production, clinical mastitis, milk lactose, somatic cell score, fat yield, and udder morphology. This study enabled the identification of several candidate genes associated with LCP, enhancing our understanding of the genomic architecture underlying LCP in American Holstein cattle. - Source: PubMed
Publication date: 2026/05/04
Fotso-Kenmogne Patrick RCarneiro Paulo L SSilva Delvan ALázaro Sirlene FAponte Pedro F CCobuci Jaime AOliveira Hinayah RBrito Luiz F - Although inhibitors of oncogenic KRAS have shown clinical efficacy, resistance to KRAS inhibition is common, and its molecular basis remains unclear. Here we show that KRASi-resistant cancer cells sustain mitochondrial bioenergetics through enhanced fatty acid (FA) metabolism, despite suppression of canonical KRAS signaling. Specifically, KRASi-resistant pancreatic cancer cells exploit macropinocytosis to scavenge FA released from adipose tissue, fueling beta-oxidation independently of KRAS-PI3Kα signaling. This adaptive metabolic program is driven by the adhesion G protein-coupled receptor ADGRB1, which activates non-canonical PI3Kγ-PAK1 signaling to stimulate macropinocytosis and maintain metabolic homeostasis under KRASi. Disruption of ADGRB1-PI3Kγ signaling dismantles this metabolic program and restores KRASi sensitivity. This pathway operates across multiple KRAS-mutated cancers and is associated with poor therapeutic response and outcome. These findings offer a promising strategy for overcoming KRASi resistance. - Source: PubMed
Publication date: 2026/04/03
Yuan ZihangLin BoWang ChunlanMiao YingyingZhang DaMeng ZiruWang GangqiLowy Andrew MKarin MichaelYang FeiSun BeichengSu Hua - - Source: PubMed
Publication date: 2026/04/03
Chi DongxuanChu HongyuanNie JingZhang YanqinWang FangDing Jie - The adhesion G-protein coupled receptors (aGPCRs) are a family of 33 G-protein receptors consisting of ADGRA1-3, ADGRB1-3, ADGRC1-3, ADGRD1-2, ADGRE1-5, ADGRF1-5, ADGRG1-7, ADGRL1-4, and ADGRV1. Recent studies have unveiled the role of aGPCRs in numerous brain functions, including in neurodevelopment, synapse formation and maintenance, establishment of the blood-brain barrier, and myelination. Further, dysfunction of aGPCRs have been associated with disorders such as gliomas, depression, and epilepsy, among many others. Herein, we review generalized properties of aGPCRs, their brain-specific expression, associations with neurological and psychiatric diseases, and potential as future pharmacological targets. - Source: PubMed
Publication date: 2025/11/24
Lee Brandon HMeyer Christina MSpeca David JDíaz Elva - The role of efferocytosis in chronic rhinosinusitis (CRS), particularly CRS with nasal polyps (CRSwNP), remains poorly understood. - Source: PubMed
Publication date: 2026/02/02
Liang ShuangYan BingShen ShenLi YingZhang LuoWang Chengshuo