Polyclonal Rabbit AVPR2 Antibody
- Known as:
- Polyclonal Rabbit AVPR2 Antibody
- Catalog number:
- KA0357
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- KareBay
- Gene target:
- Polyclonal Rabbit AVPR2 Antibody
Related genes to: Polyclonal Rabbit AVPR2 Antibody
- Gene:
- AVPR2 NIH gene
- Name:
- arginine vasopressin receptor 2
- Previous symbol:
- DIR3, DIR
- Synonyms:
- V2R
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 1992-02-28
- Date modifiied:
- 2019-04-23
Related products to: Polyclonal Rabbit AVPR2 Antibody
Related articles to: Polyclonal Rabbit AVPR2 Antibody
- Renal function in humans and rodents displays a clear circadian pattern with greater glomerular filtration and excretion during the active period. Vasopressin (AVP) regulates water balance primarily through the vasopressin receptor 2 (V2R). Although both V2R agonists and antagonists are used clinically, it remains unclear whether their efficacy vary by the time of day. Because mRNA expression is greater during the active phase in mice, we hypothesized that V2R agonism and antagonism would produce diurnal effects on urine-concentrating responses. Adult male and female C57BL/6J mice were studied. To suppress endogenous AVP, mice were placed on a high-water gel diet one week before a 10 μg intraperitoneal injection of dDAVP at ZT5 or ZT17 and then samples collected one hour later. dDAVP administered during the active period resulted in a more diluted plasma, reflected by lower plasma osmolality at ZT18. This response associated with increased abundance of AQP2 phosphorylated at S256 and S261 in the outer medulla of the ZT18 mice compared to the ZT6 mice. Thus, dDAVP is more effective during the active period when water intake is greatest and there is enhanced renal filtration and reabsorptive capacity. Conversely, when the V2R was inhibited by tolvaptan, urine flow peaked 2 hours post the injection in the male and female mice, regardless of it was ZT18 or ZT6. However, male mice produced significantly more urine than the female mice in response to the tolvaptan. In conclusion, both time of day and sex significantly influenced renal responses to V2R-targeted therapies. - Source: PubMed
Publication date: 2026/05/14
Nguyen HungHuynh Nha VHyndman Kelly A - - Source: PubMed
Publication date: 2026/04/15
Aksoy Özlem YükselUğurlu Aylin KilinçOğuz Şerife SunaÖzlü Sare GülfemYazicioğlu BurcuInözü MihribanÇayci Fatma ŞemsaBayrakci Umut Selda - Hereditary nephrogenic diabetes insipidus (HNDI) type1 is a rare genetic disorder that results from mutations in the gene, which encodes the arginine vasopressin receptor 2. The primary clinical manifestations of this disorder encompass polydipsia, polyuria and urine with low specific gravity. At present, there is no curative treatment, and the principal treatment goal is to manage symptoms in order to prevent complications such as dehydration, brain injury, and hydroureteronephrosis. - Source: PubMed
Publication date: 2026/02/26
Huang YuanLiu LinglingMa DiLu YuanyuanFang FengLiu Xinglou - This study investigates the mechanisms underlying drought adaptability in Duolang sheep, a local breed from two distinct habitats in Xinjiang-an arid southern region and a grassland northern region-aiming to identify key factors driving differential environmental adaptation. Integrated multi-omics analyses were performed, including serum biochemical assays, untargeted metabolomics of perirenal and tail fat tissues, and transcriptomic profiling of lung, liver, and kidney samples. Our results revealed notable differences: (1) serum levels of GSH-Px, IL-2, and IgG were significantly higher in the southern group ( < 0.01); (2) metabolomic analysis identified key differential metabolites, including EPA (involved in unsaturated fatty acid biosynthesis), choline (glycerophospholipid metabolism), L-serine and glutathione (cofactor biosynthesis), and taurine (sulfur metabolism); and (3) transcriptomic analysis revealed significant differential expression of genes such as FGF21 (thermogenesis), CD14 and DUSP2 (MAPK signaling pathway), GOT1 (arginine biosynthesis), and AVPR2 (vasopressin-regulated water reabsorption). Integrative correlation analysis further indicated that glutathione, EPA, GOT1, and CD14 are involved in energy and lipid metabolism, while taurine, AVPR2, and DUSP2 contribute to oxidative stress resistance and immune regulation. These molecular and metabolic adjustments collectively enhance drought adaptability in southern Xinjiang Duolang sheep. In conclusion, adaptation to arid environments requires enhanced antioxidant capacity and immune function, with metabolites such as EPA supporting lipid metabolism and genes such as FGF21 regulating fatty acid oxidation to limit triglyceride accumulation. - Source: PubMed
Publication date: 2026/03/12
Jiang BingjieChen BinYang YalingChen YongLiu Wujun - Schizophrenia (SCZ) is a complex psychiatric disorder, and its pathogenic mechanisms are not yet fully understood. The identification of reliable blood biomarkers and molecular subtypes for early diagnosis and effective therapy remains a significant challenge. To address this issue, we utilized a combination of bioinformatics and machine learning (ML) to identify potential biomarkers for SCZ. Our approach involved the integration of 12 different ML algorithms to develop a diagnostic signature based on data from several datasets, including GSE18312, GSE27383, GSE38485, GSE54913, and GSE165604. A nomogram was constructed using these datasets for potential clinical applications. In addition, clustering analysis was performed on SCZ patients using consensus clustering and non-negative matrix factorization (NMF) algorithms. We further evaluated subtype differences in biological functions and immune cells through various methods, such as gene set enrichment analysis (GSEA), gene set variation analysis (GSVA), Proteomaps, and IOBR analyses. Our results identified a diagnostic signature composed of 16 genes (APBB2, CLCN1, SYDE1, PAX5, SNAI1, DAZL, UNC93B1, PLAGL2, HS3ST1, ITPKB, PILRA, BTLA, SWAP70, AZI2, ADM, and AVPR2), which demonstrated robust performance in diagnosing SCZ across eight different datasets. A nomogram based on these genes was created, providing clinical benefits for SCZ patients. Among the identified genes, AZI2 was found to be the most critical, influencing inflammation and immunity. We also identified potential chemical compounds that could target these 16 genes. Unsupervised clustering and NMF algorithms revealed two distinct subtypes of SCZ, each associated with unique immune cell profiles, biological functions, and protein expression levels. In conclusion, this study not only developed a diagnostic signature and a novel nomogram for SCZ but also provided new insights into the subtypes of SCZ. These findings may pave the way for personalized diagnosis and treatment strategies for SCZ patients. - Source: PubMed
Publication date: 2026/03/24
Li ZhijunSun QingLi HaoyuGuan NaiyuNi JingWang JingXu XiaoleiShen YeSun SiyuLi Yan