Polyclonal Rabbit EPHA7 Antibody
- Known as:
- Polyclonal Rabbit EPHA7 Antibody
- Catalog number:
- KA1218
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- KareBay
- Gene target:
- Polyclonal Rabbit EPHA7 Antibody
Ask about this productRelated genes to: Polyclonal Rabbit EPHA7 Antibody
- Gene:
- EPHA7 NIH gene
- Name:
- EPH receptor A7
- Previous symbol:
- -
- Synonyms:
- Hek11
- Chromosome:
- 6q16.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-10
- Date modifiied:
- 2016-10-05
Related products to: Polyclonal Rabbit EPHA7 Antibody
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- Although human papillomavirus (HPV) testing and Thin-Prep Cytology Test (TCT) are currently adopted as the first-line screening methods for cervical cancer, both of them have limitations. This study aimed to develop and validate new methylation-based biomarkers from formalin-fixed paraffin-embedded (FFPE) tissue and TCT samples in a Chinese population to improve early detection of cervical cancer (CC). - Source: PubMed
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Daniel Muteb MuyeyAndwey Gradel Holel - The Median Raphe (MR) provides a major, mainly serotonergic, input to the hippocampus, particularly influencing the dentate gyrus (DG), but its specific role remains unclear. Here, focusing on the dorsal DG, we investigated its contribution to anxiety-like behavior and learning under stress, using a pathway-specific chemogenetic approach in male Sprague-Dawley rats. Retrograde Cre-expressing AAV was injected into the dorsal DG, and Cre-dependent excitatory (hM3Dq) or inhibitory (hM4Di) DREADDs were expressed in MR neurons. Behavioral assessments included the Open Field (OF), Elevated Plus Maze (EPM), and an extended Two-Way Shuttle Avoidance task (eTWSA). MR-dorsal DG pathway activation had no significant impact, but its inhibition decreased anxiety-like behavior in the EPM and improved eTWSA performance, particularly in behaviorally “diverged” animals. Knocked down in the dorsal DG EphA7, a molecule involved in basket cell synapse stabilization on DG granule cells, prevented the anxiolytic effects and behavioral divergence induced by MR-dorsal DG inhibition, but did not prevent improved eTWSA performance. These findings suggest a dissociation between mechanisms of emotional regulation and stress-related learning mechanisms within the dorsal DG, with the MR input to DG basket interneurons modulating anxiety but not learning flexibility. The results highlight a subregion- and pathway-specific role of the MR-hippocampal input in modulating behavior. - Source: PubMed
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