Polyclonal Rabbit HLA-DOB Antibody
- Known as:
- Polyclonal Rabbit Human leukocyte antigen-DOB Antibody
- Catalog number:
- KA1660
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- KareBay
- Gene target:
- Polyclonal Rabbit HLA-DOB Antibody
Related products to: Polyclonal Rabbit HLA-DOB Antibody
Related articles to: Polyclonal Rabbit HLA-DOB Antibody
- To identify key genes associated with rheumatoid arthritis (RA) and explore their roles in disease pathogenesis using genomic and single-cell transcriptomic data, with the aim of proposing novel therapeutic targets. - Source: PubMed
Liu MiaoLang Wen-JingLi Ling - The novel null allele HLA-DOB*01:18N was identified in seven individuals using single molecule real-time sequencing. - Source: PubMed
French Albert J ENatajaran Richard H LHopper Sebastian J FTurner Thomas RMayor Neema P - Psoriasis is a chronic inflammatory skin disease associated with immune dysfunction, and its relationship to cutaneous melanoma is unclear. This study used Mendelian randomization (MR) to explore the causal link between the two and identify risk genes. SNPs from a psoriasis GWAS (5,072 cases, 478,102 controls) were used as instrumental variables, and melanoma GWAS data (3,751 cases, 372,016 controls) served as the outcome. Causal relationships were assessed using IVW, MR-Egger, and weighted median methods, with sensitivity tests. Co-localization and transcriptome analyses identified risk genes. Forward MR showed psoriasis significantly reduced melanoma risk (PIVW=0.040). The co-localization analysis revealed genes positively associated with the risk of psoriasis, including HLA-DOB, NOTCH4, and VARS2. HLA-DOB was the only risk gene of psoriasis that showed differential expression in cutaneous melanoma based on transcriptional analysis. HLA-DOB was downregulated in melanoma and associated with better prognosis (P=0.033). Single-cell analysis showed that HLA-DOB was mainly enriched in B cells (especially memory B cells) and myeloid cells (particularly DC: monocyte-derived). Our findings suggest an inverse causal relationship between melanoma and psoriasis. Importantly, we also found that HLA-DOB can be served as a key "coordinator" between cutaneous melanoma and psoriasis: a risk gene of psoriasis and a protective factor of cutaneous melanoma. - Source: PubMed
Publication date: 2025/07/24
Li YingxiLuo JingTian DongchenLi ChenxiWu ChenWang GuixinGuo RuitanHe LongLi LinTian YaoHu Lizhi - Male genital lichen sclerosus-induced urethral stricture is a chronic inflammatory disease with significant microbiota dysbiosis. However, dysbiosis inside lesion tissue and its correlation with gene expression in male genital lichen sclerosus (MGLSc) remain elusive. This study investigated the influence of host-microbe interactions on dysbiosis and differential gene expression in MGLSc. Microbiome and transcriptome sequencing were conducted using prepuce samples from 27 MGLSc patients and 17 controls. We also performed immunohistochemistry staining of bacterial markers on prepuce tissue from two cohorts. Furthermore, potential risk factor information available from the MGLSc clinical data was collected and correlated with the differential microbiota. Unclassified Muribaculaceae and were enriched, while , , , and , etc., were reduced in MGLSc tissues and decreased in gram-positive bacteria ( < 0.05). The functions of differentially expressed genes (DEGs) were associated with immune activation, inflammatory response, innate immunity, and pathogen response. DEGs related to pathogen recognition, such as , , , and , were upregulated ( < 0.05). Single-sample gene set enrichment analysis revealed MGLSc lesions enriched immune cells. Clinical correlation analysis indicated that differential microbota was negatively correlated with age ( < 0.05) and stricture grade ( < 0.05) and was positively correlated with total cholesterol levels ( < 0.05), body mass index ( < 0.05), and triglyceride levels ( < 0.05). Our study provides preliminary clues on host-microbe interactions in MGLSc development, suggesting that tissue dysbiosis may be associated with localized immune dysregulation. - Source: PubMed
Publication date: 2025/08/18
Yu ZhenweiWang ZeyuMao GuangyuTang JuanZhang RuihangSong LujieXiu Xianjie - Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Genome-wide association studies have identified 4 common inherited variants associated with AML risk, but these findings have not yet been confirmed in many independent data sets. Here, we performed a replication study with 567 AML cases from the Leucegene cohort and 1865 controls from the population-based cohort CARTaGENE (CaG). Because genotypes were generated using different technologies in the 2 data sets (eg, low- vs high-coverage whole-genome sequencing), we applied stringent quality-control filters to minimize type 1 errors. We showed, using data reduction methods (eg, principal component analysis and uniform manifold approximation and projection), that our approach successfully integrated the Leucegene and CaG genetic data. We replicated the association between cytogenetically normal AML and rs3916765, a variant located near (odds ratio, 1.96; 95% confidence interval, 1.26-3.06; = .003). The effect size of this association was stronger when we restricted the analyses to patients with AML with mutations (odds ratios of >2.25). We also found that rs3916765 is a whole-blood expression quantitative trait locus for ( = 1.05 × 10) and ( = 2.23 × 10). Our results confirm that a common genetic variant at the HLA locus associates with AML risk and the expression of HLA class 2 genes, providing new opportunities to improve disease prognosis and treatment. - Source: PubMed
Publication date: 2025/05/19
Laflamme RoseLisi VéroniqueHébert JoséeSauvageau GuyLemieux SébastienLavallée Vincent-PhilippeLettre Guillaume