Polyclonal Rabbit JIP3 Antibody
- Known as:
- Polyclonal Rabbit JIP3 Antibody
- Catalog number:
- KA1848
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- KareBay
- Gene target:
- Polyclonal Rabbit JIP3 Antibody
Related genes to: Polyclonal Rabbit JIP3 Antibody
- Gene:
- MAPK8IP3 NIH gene
- Name:
- mitogen-activated protein kinase 8 interacting protein 3
- Previous symbol:
- -
- Synonyms:
- KIAA1066, JSAP1, JIP3, syd
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-08-22
- Date modifiied:
- 2014-11-19
Related products to: Polyclonal Rabbit JIP3 Antibody
Related articles to: Polyclonal Rabbit JIP3 Antibody
- In recent years, substantial heterogeneity in lysosomes, in terms of their composition, function, and positioning, has come to be recognized. Despite this, there are gaps in knowledge of our understanding of the molecular basis of lysosome heterogeneity, especially in neurons. To this end, we used electron microscopy to define endolysosomal organelles of human iPSC-derived neurons at the ultrastructural level. Through this, we identify endolysosomal maturation defects within neuronal cell bodies of iNeurons lacking JNK-Interacting Protein 3 (JIP3), a lysosome adaptor previously known to primarily regulate axonal lysosome movement. Loss of JIP3 results in an expansion of immature lysosomes within neuronal soma, along with a concomitant decrease in mature lysosomes. JIP3 loss also leads to delayed trafficking of endocytic cargo through these compartments, implicating JIP3 in the regulation of endolysosomal maturation within neuronal cell bodies. Our studies highlight the utility of electron microscopy in understanding neuronal lysosomal heterogeneity. Additionally, given recent links between JIP3 and a neurodevelopmental disorder, our findings here could provide new insight into mechanisms underlying neurodevelopmental pathology. - Source: PubMed
Publication date: 2026/05/28
Krout MiaGowrishankar Swetha - Obsessive compulsive disorder (OCD) is significantly heritable, but only a fraction of the contributory genetic variation has been identified, and the molecular etiology involved remains obscure. Identifying rare contributory variants of large effect would be an important milestone in helping to elucidate the mechanisms involved. Analysis of densely affected pedigrees is a potentially useful strategy to bypass the sample size challenges of standard case-control approaches. Here we performed whole genome sequencing (WGS) of 25 individuals across two multiplex OCD pedigrees. We prioritised rare variants using a Bayesian inference approach which incorporates variant pathogenicity and co-segregation with OCD. In the first pedigree, we identified a highly deleterious missense variant in , carried by the majority of affected individuals. This gene is brain-expressed and has previously been implicated in panic disorder and internet addiction GWAS studies. In the second pedigree, we identified a large deletion of and a missense variant in , that perfectly co-segregated in a specific branch of the family: both genes have previously been implicated in OCD and autism. Both genes contribute to a protein interaction network including and which we had previously identified in a large Tourette Syndrome pedigree. Our analysis suggests that both energy homeostasis and downstream signalling from the post-synaptic density may both be important avenues for future research. - Source: PubMed
Publication date: 2026/04/22
Ormond CathalCap MathieuChang Yi-ChiehRyan NiamhChavira DeniseWilliams KyleGrant Jon EMathews CarolHeron Elizabeth ACorvin Aiden - The gene encodes JIP3, a kinesin-1 adapter protein crucial for axonal transport and JNK signaling pathway regulation. This gene exhibits extreme intolerance to loss-of-function variants. Heterozygous pathogenic variants are linked to a neurodevelopmental disorder with or without variable brain abnormalities (NEDBA). This study characterizes a novel inherited canonical splice-site variant identified in a three-generation family. - Source: PubMed
Publication date: 2026/04/16
Yi ShengYang QiSong XiongHuang LimeiYi ShangQin ZailongLuo Jingsi - Indigenous poultry genetic resources are crucial for breeding and food security. In Xinjiang, China, the Ili gamecock and Yemili chicken represent two indigenous breeds with distinct and valuable traits. The Ili gamecock is prized for its large body size and aggressive behavior, whereas the Yemili chicken shows remarkable adaptation to the cold environment of the Tacheng area, with strong disease resistance, and foraging ability suited to free-range grazing. As understanding their genetic basis is key to their conservation and sustainable use, we conducted whole-genome sequencing of 22 individuals from both breeds and integrated the data with 83 publicly available genomes to construct a comprehensive dataset of 12 global chicken populations. After identifying over 11.3 million high-quality SNPs, we assessed genetic diversity and population structure. Analyses revealed that the Ili gamecock is closely related to the Turpan gamecock, forming a distinct cluster. Selection signature analyses based on fixation index (FST) and nucleotide diversity ratio (π ratio) identified genomic regions under positive selection associated with aggressiveness and muscularity in gamecocks (e.g., NELL1, SOX5, SEMA3A, KCNMA1) and with stress response, intestinal integrity, and energy homeostasis in Yemili chickens (e.g.,MAPK8IP3, HBEGF, PARD3, ATP6V1B2, ATP5PD). This study provides a comprehensive genomic landscape of these two emerging Xinjiang breeds, elucidates their unique evolutionary histories, and offers valuable genetic resources for future conservation and breeding programs. - Source: PubMed
Publication date: 2026/03/21
Yang HaichenLiang QianqianSu PengAndersson GöranBongcam-Rudloff ErikRouzi MahabaJiang LinHan JilongYang Min - Pishan Red Sheep and Hu Sheep are sheep breeds with exceptional reproductive characteristics. To investigate the similarities and differences in the expression of reproduction-related genes between these two breeds, this study utilized transcriptome sequencing to identify differentially expressed lncRNAs and mRNAs in ovarian tissues during estrus in Hu Sheep and Pishan Red Sheep carrying and genotypes. Furthermore, we explored their potential impacts on fertility. Transcriptome sequencing of ovarian tissues generated 204.58 Gb of clean data. Bioinformatics analysis identified 34,651 lncRNAs, with differential expression analysis revealing 1,481 differentially expressed mRNAs and 698 differentially expressed lncRNAs. Differentially expressed RNAs associated with reproductive performance trends were screened through expression trend analysis. Functional enrichment analysis of target genes for these mRNAs and lncRNAs revealed significant enrichment in KEGG pathways such as "Cytokine-cytokine receptor interaction," "Hippo signaling pathway" and "MAPK signaling pathway" Key candidate mRNAs were identified, including , , , , , , , , , , and . Additionally, critical regulatory relationships between lncRNAs and mRNAs were uncovered. For example, exhibited high expression in genotype Pishan Red Sheep and may act as a hub regulator in follicular selection and hormonal responses by cis-regulating and trans-regulating , , may regulate genes such as and , potentially participating in the modulation of the ovarian tissue remodeling microenvironment. In contrast, cis-regulates to modulate the granulosa cell proliferation and differentiation process. The specifically highly expressed in Hu Sheep may be involved in maintaining ovarian stromal cell homeostasis through trans-regulation of and , and target and respectively, suggesting their potential roles in cell cycle regulation and oocyte maturation. These findings provide important molecular mechanisms and potential regulatory targets for improving reproductive performance in sheep. - Source: PubMed
Publication date: 2025/09/24
Muhetaer AisimaGong GaoYe YaoyangKuxitaer AyipareZhu MengtingLi QifaDu XingSulaiman Yiming