Polyclonal Rabbit BMP8B Antibody
- Known as:
- Polyclonal Rabbit BMP8B Antibody
- Catalog number:
- KA0424
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- KareBay
- Gene target:
- Polyclonal Rabbit BMP8B Antibody
Related genes to: Polyclonal Rabbit BMP8B Antibody
- Gene:
- BMP8B NIH gene
- Name:
- bone morphogenetic protein 8b
- Previous symbol:
- BMP8
- Synonyms:
- OP-2
- Chromosome:
- 1p34.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-02
- Date modifiied:
- 2016-10-05
Related products to: Polyclonal Rabbit BMP8B Antibody
Related articles to: Polyclonal Rabbit BMP8B Antibody
- Bone morphogenetic proteins (BMPs) are bone-derived osteokines that regulate energy metabolism and combat obesity by promoting brown adipocyte differentiation. BMP4, BMP7, BMP8B, and BMP9 are highly expressed in osteoblasts and bone matrix, from which they are released into circulation. They act as endocrine factors that induce brown adipogenesis, increase mitochondrial biogenesis, and increase thermogenesis via conserved signaling pathways (Smad, MAPK, and PGC1α). Concurrently, these BMPs maintain skeletal homeostasis and mediate crosstalk between bone and metabolic organs, including adipose tissue and the hypothalamus, thereby regulating appetite and energy balance. Preclinical studies have confirmed that BMP-based interventions can increase energy expenditure, improve insulin sensitivity, and alleviate obesity-related complications. However, clinical translation remains hindered by adverse effects, short half-lives, and obesity-induced BMP resistance. This review first elucidates the peripheral and central regulatory mechanisms of BMPs in energy metabolism, clarifies the subtype-specific metabolic effects of major BMPs, further evaluates their therapeutic potential against obesity and metabolic syndrome, and finally analyzes the core obstacles to clinical implementation and corresponding solution strategies. - Source: PubMed
Publication date: 2026/06/18
Zhang JingJiang NanWang Li-JuanCao Ting-BingXie Yang-LiLi Li - Primordial germ cells (PGCs), the precursors of sperm and oocytes, are specified from a subset of epiblast cells during the post-implantation stage of mammalian embryonic development. Over the past decade, primordial germ cell-like cells (PGCLCs) have been successfully generated from mouse and human embryonic stem cells (ESCs). PGCLC differentiation provides a powerful system to study germ cell specification and epigenetic reprograming. Notably, mouse PGCLCs can further mature into functional sperm following transplantation into neonatal testes. Despite these advancements, in vitro PGCLC differentiation remains inefficient, highlighting gaps in our understanding of PGC specification. - Source: PubMed
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Kumar UmeshKumar NithyapriyaChandra Shekar PThangaraj Kumarasamy - Bone morphogenetic proteins (BMPs) are associated with the prognosis of various types of adult cancers. However, the expressions and prognosis of BMPs in pediatric neuroblastoma remain unclear. - Source: PubMed
Publication date: 2026/02/03
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