Polyclonal Rabbit B4GALT5 Antibody
- Known as:
- Polyclonal Rabbit B4GALT5 Antibody
- Catalog number:
- KA0367
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- KareBay
- Gene target:
- Polyclonal Rabbit B4GALT5 Antibody
Related genes to: Polyclonal Rabbit B4GALT5 Antibody
- Gene:
- B4GALT5 NIH gene
- Name:
- beta-1,4-galactosyltransferase 5
- Previous symbol:
- -
- Synonyms:
- beta4GalT-V
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1999-03-15
- Date modifiied:
- 2016-10-05
Related products to: Polyclonal Rabbit B4GALT5 Antibody
Related articles to: Polyclonal Rabbit B4GALT5 Antibody
- Abnormal glycosylation modifications are pivotal in tumorigenesis. However, the mechanism by which Helicobacter pylori (H. pylori) infection affects glycosylation during gastric cancer (GC) progression is not well understood. This study investigated how H. pylori infection-related glycosylation contributes to GC, aiming to uncover new therapeutic targets. - Source: PubMed
Publication date: 2026/05/05
Tuo WenbinQu ZiluXiang TianYuan ChunhuiCai QinzhenLiu GaoWang JunXiang Yun - Altered cell-surface glycans are established cancer biomarkers, yet no oncogenes have been identified within glycan biosynthesis machinery. This represents a critical gap, as defining a gene as a true oncogene, rather than merely a component of an oncogenic pathway, reveals targetable dependencies that can improve clinical decisions. To date, no gain-of-function mutations have been detected in glycogenes, and the search for such mutations is largely saturated. To address this gap, we developed a bioinformatic-experimental pipeline to identify copy number alteration (CNA)-based driver genes, overcoming noise from passenger genes. The approach recovered known oncogenes and tumor suppressors, while revealing novel candidates, including glyco-oncogenes. Focusing on the glycosphingolipid (GSL) biosynthetic pathway, we validated as a bona fide glyco-oncogene whose genomic amplification drives proliferation, oncogene addiction, and poor prognosis, effects that can be reversed by targeted pathway inhibition. Mechanistic studies show that B4GALT5 promotes cancer cell survival via integrin-Src signaling under anchorage-independent conditions. Collectively, these findings establish glycosylation enzymes as a druggable oncogene class and provide a resource of high-confidence CNA-based cancer regulatory genes. - Source: PubMed
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Sahu PranoyRusso FrancescoRusso DomenicoAgliarulo IleniaAmbrosio PasqualinaRizzo RiccardoLo Monte MatteoNormanno NicolaSoddu SilviaCarlomagno FrancescaLuini AlbertoParashuraman Seetharaman - Focal segmental glomerulosclerosis (FSGS) is a major cause of nephrotic syndrome and chronic kidney disease, characterized by podocyte injury and glomerular scarring. Its heterogeneity complicates early diagnosis and treatment. - Source: PubMed
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Zhang JingkeNing HanHou YunTang Ning - Sheep have diversified into distinct breeds worldwide through both natural adaptation and human-driven selection, with hybridization serving as an effective strategy for rapid trait improvement. The Tianhua mutton sheep (TMS) is a novel breed derived from crossing South African Mutton Merino (SAMM) with Gansu alpine fine-wool sheep (GAFS). After nearly two decades of selective breeding, TMS has developed great meat quality traits and impressive cold tolerance at high altitudes. To study the genetic mechanism and provide new insights into phenotypic variation, we analyzed the genetic diversity, population structure, and selective signatures of TMS based on whole-genome sequencing of 55 TMS, 11 SAMM, and 197 public sheep genomes worldwide. - Source: PubMed
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