Polyclonal Rabbit B4GALT1 Antibody
- Known as:
- Polyclonal Rabbit B4GALT1 Antibody
- Catalog number:
- KA0365
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- KareBay
- Gene target:
- Polyclonal Rabbit B4GALT1 Antibody
Related genes to: Polyclonal Rabbit B4GALT1 Antibody
- Gene:
- B4GALT1 NIH gene
- Name:
- beta-1,4-galactosyltransferase 1
- Previous symbol:
- GGTB2
- Synonyms:
- beta4Gal-T1
- Chromosome:
- 9p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: Polyclonal Rabbit B4GALT1 Antibody
Related articles to: Polyclonal Rabbit B4GALT1 Antibody
- Dietary patterns can modulate the expression of proteins involved in inflammatory and metabolic pathways in people living with HIV. The aim of this study was to examine whether adherence to the Mediterranean diet is associated with distinct plasma proteomic signatures in PWH on stable antiretroviral therapy. Chronic inflammation persists despite virological suppression, making diet a potential modifiable factor in this setting. - Source: PubMed
Publication date: 2026/04/22
Manzano MónicaMoreno ElenaMartín-Pedraza LauraDíaz-García ClaudioMoreno SantiagoNavia BeatrizSerrano-Villar Sergio - Osteoarthritis (OA) is a prevalent degenerative joint disease with an unclear molecular pathogenesis. B4GALT1 has been implicated in various pathological processes, but its role and mechanism in OA remain largely unexplored. - Source: PubMed
Publication date: 2026/04/17
Ma WeibangOuYang DongXu ZheLuo WeiTian GuangJiang NingLiu ChenZhang RuguoYu Qiao - Cytotoxic CD8 T-cells play central roles in tumor immunotherapy. Understanding the mechanisms that regulate development, differentiation, and functions of cytotoxic CD8 T-cells leads to the development of better immunotherapies. By combining primary T-cell culture and a syngeneic mouse tumor model with both genome-wide and custom CRISPR/Cas9 screenings, we systematically identified genes and pathways that regulate PD-1 expression and functions of CD8 T-cells. Among them, inactivation of a key enzyme in glycoconjugate biosynthesis, beta 1,4-galactosyltransferase 1 (B4GALT1), leads to significantly enhanced T-cell receptor (TCR) activation and functions of CD8 T-cell. Interestingly, suppression of B4GALT1 enhances functions of TCR-T-cells, but has no effect on chimeric antigen receptor T (CAR-T) cells. We systematically identified the substrates of B4GALT1 on CD8 T-cell surface by affinity purification and mass spectrometry analysis, which include protein components in both TCR and its co-receptor complexes. The galactosylation of TCR and CD8 leads to reduced interaction between TCR and CD8 that is essential for TCR activation. Artificially tethering TCR and CD8 by a TCR-CD8 fusion protein could bypass the regulation of B4GALT1 in CD8 T-cells. Finally, the expression levels of B4GALT1 normalized to tumor-infiltrated CD8 T-cells in tumor microenvironment are significant and negatively associated with prognosis of human patients. Our results reveal the important roles of protein N-glycosylation in regulating functions of CD8 T-cells and prove that B4GALT1 is a potential target for tumor immunotherapy. - Source: PubMed
Publication date: 2026/03/20
Hong YuSi XiaofangLiu WenjingMai XueyingZhang Yu - Lipotoxicity, driven by dysregulated lipid metabolism, is a key initiator of hepatocyte injury in metabolic dysfunction-associated steatotic liver disease (MASLD). β-1,4-galactosyltransferase 1 (B4GALT1), which primarily mediates galactosylation of glycoproteins and glycolipids, is involved in the regulation of plasma lipid composition. Previous studies have implicated aberrant glycosylation in MASLD progression. However, the role and underlying molecular mechanisms of B4GALT1 in MASLD progression remain unclear. - Source: PubMed
Publication date: 2026/03/20
Chien YoujungXia RuiqiZhou DaAi YingjieWu LinfengZeng XiaoqingChen Shiyao - The role of Bisphenol A (BPA) in endometrial cancer (EC) remains uncertain. In this study, we integrated toxicological prediction, network toxicology, gene expression profiling, survival analysis, and molecular docking to explore potential BPA-associated molecular features in EC. Toxicological predictions from ADMETLAB 3.0 and ProTox-3 suggested a potential affinity of BPA for estrogen receptor α (ERα), along with possible involvement in oxidative stress and mitochondrial dysfunction. Integrative database analysis identified 129 putative BPA–EC–related genes, and GO/KEGG enrichment analyses indicated enrichment in angiogenesis-related processes and dysregulation of EGFR, MAPK, and FoxO signaling pathways. Analysis of TCGA-UCEC data identified 48 differentially expressed genes, among which five genes (ESR1, NOTCH1, GABARAP, B4GALT1, and PAN3) showed significant associations with overall survival in univariate Cox regression analyses. Kaplan–Meier analysis indicated that higher expression of GABARAP and NOTCH1 was associated with poorer survival, whereas higher expression of ESR1 and B4GALT1 was associated with more favorable outcomes. External validation using the GEO dataset GSE17025 supported differential expression patterns and prognostic relevance for ESR1, PAN3, B4GALT1, and NOTCH1. Molecular docking analyses indicated theoretical structural interaction feasibility between BPA and several key proteins, based on in silico simulations. Collectively, these findings provide bioinformatic and toxicogenomic evidence suggesting potential associations between BPA exposure and EC-related molecular pathways. This study is hypothesis-generating and may help prioritize candidate genes and pathways for future experimental validation and mechanistic investigation. - Source: PubMed
Publication date: 2026/03/18
Yang YihanZhang XuesongXue MengWu XujinKong MingyueLi TianjiaoDai ZiqiXu YueChen Xin