RPL37A antibody Ab host: Rabbit
- Known as:
- RPL37A (anti-) Antibody production species: Rabbit
- Catalog number:
- 'C14179-1
- Product Quantity:
- 50 Вµg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- RPL37A antibody host: Rabbit
Related genes to: RPL37A antibody Ab host: Rabbit
- Gene:
- PPP1R18 NIH gene
- Name:
- protein phosphatase 1 regulatory subunit 18
- Previous symbol:
- KIAA1949
- Synonyms:
- phostensin
- Chromosome:
- 6p21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-02
- Date modifiied:
- 2016-10-05
- Gene:
- RPL37A NIH gene
- Name:
- ribosomal protein L37a
- Previous symbol:
- -
- Synonyms:
- L37A
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1993-05-14
- Date modifiied:
- 2015-08-25
Related products to: RPL37A antibody Ab host: Rabbit
Related articles to: RPL37A antibody Ab host: Rabbit
- The river buffalo is an economically important livestock species supplying milk and meat. However, a multi-tissue transcriptomic atlas for the key dairy river buffalo breeds, Murrah and Nili-Ravi, has not yet been established, and the lack of stable reference genes has hindered in-depth studies of their biological functions and the molecular mechanisms underlying key economic traits such as lactation. We established a multi-tissue gene expression atlas across 20 tissues and identified 717 housekeeping genes (HKGs), and and were further shown to be stable candidate reference genes under the conditions tested. We found 8368 tissue-specific genes (TSGs), predominantly enriched in the reproductive system. Exploratory analysis of mammary tissue (dry-period vs. public lactating samples, confounded by batch effects) revealed mammary-enriched hub genes including ; these findings are preliminary and require validation. Dynamic analysis across lactation stages (early, peak, mid-, late) identified candidate genes including and . Phenotypic data showed strong negative correlations between milk yield and protein/fat content, and a positive correlation with lactose content. However, causal or regulatory roles were not inferred due to lack of paired individual-level data. Cross-dataset comparisons are descriptive only, and are not key conclusions. In summary, this study lays the foundation for advancing research in lactation trait genetics and functional genomics in river buffalo, with novel reference genes and lactation stage-specific transcriptional dynamics as its main contributions. - Source: PubMed
Publication date: 2026/04/30
Song XinhuiWang DongLuo XierQin ChaobinLi LingYang YanyanPi YifeiDeng YanfeiCui KuiqingLi ZhipengXu WeiLiu Qingyou - The aim of this study is to find potential biomarkers and drugs in intrahepatic cholestasis of pregnancy (ICP) by combining bioinformatics and experimental validation strategies. - Source: PubMed
Publication date: 2025/11/24
Zheng WenfeiZhan JingqiongCao HuarongWen MinYu MengmengPoochali Chandana Vayakkali - Endocrine-disrupting chemicals (EDCs) are pervasive environmental hazards that have been linked to osteoporosis (OP), though causal mechanisms remain elusive. Employing an integrated multiomics framework, this study combined bidirectional Mendelian randomization (MR), network toxicology, machine learning, molecular simulations, and ovariectomized rat models to elucidate causal relationships between EDCs and osteoporosis, and to identify the molecular underpinnings of these relationships. MR analyses leveraging European GWAS data identified methylparaben (MP; OR = 0.973, < 0.001) and monomethyl phthalate (MMP; OR = 0.984, p = 0.006) as causal agents reducing bone mineral density (BMD), validated across two independent cohorts. Network toxicology revealed CYP3A4 as a shared target for both EDCs, with HSPA5-driven endoplasmic reticulum (ER) stress implicated in MP-induced bone loss and CRP-mediated inflammation central to MMP pathology. Molecular dynamics simulations confirmed stable binding of MP/MMP with hub targets. Crucially, ribosomal genes (RPL9/RPL37A/RPS19) altered by MP were mechanistically linked to ER stress-induced osteotoxicity rather than direct EDC binding. In vivo validation demonstrated that MP and MMP exposure in OVX rats significantly exacerbated trabecular degradation, suppressed osteogenic markers, and elevated osteoclastic activity. This work establishes CYP3A4 as a high-value therapeutic target for countering EDC-induced osteoporosis and resolves longstanding controversies regarding the osteotoxic mechanisms of parabens and phthalates. - Source: PubMed
Publication date: 2025/12/17
Liu HailongXu XinDu LongzhuoZhang WencanGuo YongyuanZhang FujianSun HouyiSi HaipengLiu Peilai - This study aimed to explore the relationship between lipidomic domains, particularly free fatty acids (FFAs), and the presence of atrial fibrillation (AF) in patients with acute stroke, and to identify mechanisms of AF-associated stroke through genetic studies.A total of 483 stroke patients without AF ( = 391) and with AF ( = 92) were selected from a prospectively collected stroke registry. Lipidomic profiling was conducted, and the lipid components associated with AF were explored using fold-change analyses and clustering. Genotyping was conducted through trait comparison. Colocalization was also performed.Among the lipidomic domains, the free fatty acid (FFA) class was positively associated with AF. Long-chain fatty acids with 14 to 24 carbons and unsaturated FFAs distinguished AF. Clustering analysis based on FFAs revealed differences in AF proportion across groups. Genome-wide association study (GWAS) identified two loci associated with clustered groups of FFA metabolites: near MIR548F3 associated with FFA 20:1, FFA 20:2, FFA 22:5, and FFA 22:6; and near RPL37A associated with FFA 22:5 and FFA 22:6. These loci were associated with increased fibrinogen levels. In the GWAS for the FFA metabolite, quantitative trial locus analysis, loci near rs28456 and rs3770088, and FFA 20:4-QTLs were co-localized with the eQTLs of , a gene involved in the peroxisome proliferator-activated receptor gamma-related signaling pathway, in the whole blood, left ventricle, and atrial appendage tissue.Elevated FFA levels, especially those of long-chain unsaturated FFAs, are strongly associated with AF-associated stroke. This relationship is regulated by the peroxisome proliferator-activated receptor (PPAR) gamma-related signaling pathway. - Source: PubMed
Publication date: 2024/12/18
Jung YoungaeKim BeomsuKim Chi KyungWon Hong-HeeChae Su-HyunOh KyungmiShin Min-JeongHwang Geum-SookSeo Woo-Keun - Many genes used as internal controls for mRNA expression studies are unstable (change) over development. This study determined an approach to validate reference genes for mRNA studies spanning the fetal period to adulthood in sheep hearts.•We determined the mRNA expression of 12 candidate reference genes (ACTB, GAPDH, H3-3A, HYAL2, PPIA, RNA18S1, RPL32, RPL37A, RPL41, RPLP0, RPS15, and YWHAZ) via RT-qPCR. Per RefFinder, which incorporates computational algorithms by BestKeeper, comparative delta Ct, GeNorm, and NormFinder, RPL32, RPL37A, HYAL2, ACTB and GAPDH were the most stable reference genes, although none were unchanged across all ages.•Systematical calculation of the geometric means of 3 reference genes revealed the combination of HYAL2, RPL32, and RPL37A was unchanged across the 5 fetal, neonatal, and adult ages.•We determined the most stable combination of reference genes for cardiac gene expression studies in sheep from fetus to newborn to adult; these steps are applicable to determine internal controls for mRNA studies in other organs, other species, and periods in which reference gene instability is high. - Source: PubMed
Publication date: 2024/11/09
Bose KarthikeyanLouey SamanthaJonker Sonnet S