Human Cells Secretogranin-2 SCG2
- Known as:
- Human Cells Secretogranin-2 SCG2
- Catalog number:
- C634
- Product Quantity:
- l0
- Category:
- -
- Supplier:
- Novoprotein
- Gene target:
- Human Cells Secretogranin-2 SCG2
Related genes to: Human Cells Secretogranin-2 SCG2
- Gene:
- SCG2 NIH gene
- Name:
- secretogranin II
- Previous symbol:
- -
- Synonyms:
- CHGC, SgII, SN
- Chromosome:
- 2q36.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-26
- Date modifiied:
- 2016-10-05
Related products to: Human Cells Secretogranin-2 SCG2
Related articles to: Human Cells Secretogranin-2 SCG2
- Patient-derived organoids (PDOs) and organotypic slice tissues have emerged as promising platforms to model prostate cancer (PCa) in three dimensions (3D), preserving tumor architecture and molecular features. Their relevance as translational tools for precision oncology, however, remains incompletely defined. - Source: PubMed
Publication date: 2026/04/01
Peyrottes Arthurde Brek NorbertVieira Aleixo Anne-SophieBaboudjian MichaelAnract JulienRoupret MorganTimsit Marc-OlivierMéjean ArnaudGuidotti Jacques-EmmanuelGoffin VincentDariane Charles - Secretoneurin (SN) is a small, bioactive proteolytic product of secretogranin II (SCG2), a chromogranin protein involved in secretory vesicle packaging. SCG2 co-aggregates with luteinizing hormone (LH) in pituitary gonadotrope secretory granules and thus has long been associated with GnRH-regulated LH secretion. Previously, the SCG2-derived peptide SN has been identified as a regulator of LH production and secretion in fish and a murine gonadotrope-like cell line (LβT2). Though high levels of SCG2/SN are present in the mammalian pituitary, the role of pituitary SN has not been identified in mammals. It is further unknown if pituitary SN function varies with age and sex. Here, we identify a decrease in levels of precursor SCG2, and a trend towards increased levels of SN throughout postnatal developmental, particularly in females, following the onset of puberty. Additionally, proteomic and bioinformatic analyses of adult male and female pituitaries revealed protein-protein interactions between SCG2 and various peptides, many associated with prohormone processing and regulated secretion. Furthermore, we demonstrate for the first time that SN is capable of stimulating LH secretion from ex vivo mouse pituitaries, an effect previously documented only in non-mammalian vertebrate species and LβT2 cells. Exogenous SN stimulation significantly increased LH release from adult male (1.4x; p<0.01) and proestrous female (2.4x; p<0.0001) murine pituitaries. Notably, we found that SN treatment had no observed effect on LH secretion in prepubertal (PND14) male and female pituitaries, indicating that SN may function primarily in mature gonadotropes to promote fertility and estrous cycle progression. - Source: PubMed
Publication date: 2026/03/09
Herdman Ashley KLagasse AlexBolen Cole RReddick Milla MHaney AnessaOrtega Victoria GBoehm UlrichMacNicol Angus MMacNicol Melanie CMiles Tiffany KChilds Gwen VOdle Angela K - The pituitary gland plays a pivotal role in regulating puberty and reproductive physiology; however, the precise cellular and molecular mechanisms driving the pubertal transition in large animal, such as ewes, remain poorly understood. Here, we generated a comprehensive single-cell transcriptomic atlas of the ovine anterior pituitary, specifically comparing the pre-pubertal (3 month) and post-pubertal (6 month) stages. We identified 30 335 cells classified into ten distinct clusters. Comparative analysis revealed a global transcriptional reprogramming during puberty, characterized by a marked upregulation of genes associated with ribosome biogenesis, unfolded protein response, and hormone secretion across endocrine cells, reflecting an expanded biosynthetic capacity. Specifically, we identified SCG2 as a critical regulator of gonadotroph maturation. Functional validation demonstrated that SCG2 facilitates the biogenesis of secretory granules, thereby promoting FSH synthesis and secretion. Furthermore, intercellular communication analysis uncovered a distinct shift in the pituitary microenvironment: the 6 month pituitary exhibited enhanced regulatory networks, including IGF signaling mediated by non-endocrine cells and NT signaling (e.g., BDNF-NTRK2) driven by multiple cell types. These findings suggest that the onset of puberty relies on a coordinated "endocrine-to-endocrine" and "non-endocrine-to-endocrine" crosstalk. This study provides a high-resolution molecular blueprint of the pubertal transition, highlighting the key roles of biosynthetic machinery upgrades and microenvironmental remodeling in establishing the high reproductive performance of Hu sheep. - Source: PubMed
Li ShanglaiZhao BingruCai YuYang HuaXu HuiDai KekeWang FengZhang Yanli - Pancreatic neuroendocrine tumors (pNETs) present diagnostic and therapeutic challenges because of their rarity and heterogeneity. This study aimed to identify key genes involved in the development of pNETs and potentially effective prognostic biomarkers. - Source: PubMed
Publication date: 2026/01/21
Yang WuhanXu LinghuanLi HuiWang ShubinGuo HaoZhang JiaqiPeng Li - The granin gene family of neuropeptides functions as peptide neurotransmitters in the brain for the regulation of neural functions that regulate behaviors. Granins are involved in regulating cognition, memory, depression, aggression, stress, energy expenditure, inflammation, and related. Development of the human brain involves formation of synapses and their spectrum of neurotransmitters to establish neural connections that are required for brain functions. Therefore, the goal of this study was to analyze the gene expression profiles of the granin neurotransmitter genes during human brain development at prenatal, infancy, childhood, adolescence, and adult stages. Granin gene expression in brain development was assessed by quantitative RNA sequencing data from the Allen Human Brain Atlas resource. (neurosecretory protein VGF) expression was significantly increased during development during the prenatal to childhood through adult stages in the anterior cingulate cortex, dorsolateral prefrontal cortex, inferolateral temporal cortex, orbital frontal cortex, posteroventral parietal cortex, primary somatosensory cortex, and primary visual cortex regions. (secretogranin 2) expression was also significantly increased from prenatal to infancy through adult stages in anterior cingulate cortex, dorsolateral prefrontal cortex, inferolateral temporal cortex, orbital frontal cortex, posterior superior temporal cortex, posteroventral parietal cortex, primary somatosensory cortex, and primary visual cortex. A modest number of brain regions showed increased , , and expression in the postnatal periods compared to the prenatal periods. Further, the genes displayed minimal changes throughout development. Overall, these results demonstrate developmental upregulation of and genes, with lesser upregulation of , , and genes, and almost no changes in , , and genes during development. These findings illustrate the differential regulation of granin genes during human brain development. - Source: PubMed
Publication date: 2025/12/02
Demsey Laura LPodvin SoniaHook Vivian