Human Apolipoprotein D ApoD
- Known as:
- Human Apolipoprotein D ApoD
- Catalog number:
- C556
- Product Quantity:
- l0
- Category:
- -
- Supplier:
- Novoprotein
- Gene target:
- Human Apolipoprotein ApoD
Related genes to: Human Apolipoprotein D ApoD
- Gene:
- APOD NIH gene
- Name:
- apolipoprotein D
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q29
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2014-11-19
Related products to: Human Apolipoprotein D ApoD
Related articles to: Human Apolipoprotein D ApoD
- This study aimed to elucidate the role of ROS-related genes in esophageal squamous cell carcinoma (ESCC) prognosis and the cellular mechanisms involving FOXM1 and SESN2. A prognostic model incorporating six genes (FOXM1, SESN2, APOD, GATM, HEBP2, STAT1) was developed using three ESCC gene expression datasets via univariate Cox regression, LASSO-Cox algorithm, and multivariate validation. Functional assays revealed that FOXM1 knockdown elevated intracellular ROS and malondialdehyde (MDA) levels while reducing total glutathione and antioxidant capacity, impairing proliferation, migration, and cell cycle progression. RNA-seq and luciferase assays confirmed SESN2 as a transcriptional target of FOXM1. Dual knockdown of FOXM1 and SESN2 exacerbated oxidative stress, decreased mitochondrial membrane potential, and increased cell death, accompanied by mitochondrial morphological changes (reduced shrinkage, increased membrane density). Western blotting showed decreased BCL2 and GPX4 expression but increased LC3-II and -mTOR levels. These findings demonstrate that the FOXM1-SESN2 axis shields ESCC cells from oxidative stress, offering a rationale for future mechanistic investigations. - Source: PubMed
Publication date: 2026/05/05
Wu ZhishengZhang XiaonaChen MantongGao ChenmengZheng XiaoqiPeng ZhongteDu ZepengWu Bingli - The egg laying process of poultry is determined by follicular development. In the present study, hens with lower egg production rates had significantly fewer small white follicles than those with higher rates. In order to investigate the regulatory mechanisms governing the development from white follicles to yellow follicles, transcriptome sequencing was performed on small white follicles (SWFs), small yellow follicles (SYFs) and F6 (the smallest hierarchical follicles) of high-yield laying hens. Pathways enrichment analysis revealed that the vascular endothelial growth factor (VEGF) signaling, peroxisome proliferator-activated receptor (PPAR) signaling, tight junction and gap junction pathways, as well as steroid hormone biosynthesis were involved in follicular development. Compared with the transition from SYFs to F6, the transition from SWFs to SYFs showed more pronounced changes in gene expression profiles. This was validated by Western blot analysis, which revealed significantly upregulated expression of angiogenesis-related proteins (VEGF, VEGFR1, VEGFR2, ANGPT1 and ANGPT2) and downregulated expression of pigment epithelium derived factor (PEDF) in SYFs compared to SWFs. Immunofluorescence staining (IF) confirmed a markedly higher CD31-positive staining area in the theca layer of SYFs than in that of SWFs. Meanwhile, the estradiol (E) and progesterone (P) levels in SYFs increased by 131.6% and 22.2%, respectively, compared to SWFs. At the transcript level, SYFs exhibited upregulation of apolipoprotein D (ApoD), apolipoprotein A1 (APOA1), apolipoprotein L (APOLD1), PPAR and very low-density apolipoprotein (VLDL) mRNA, alongside downregulation of occludin, which was further confirmed by increased VLDLR and PPAR-γ protein abundance and decreased occludin levels. In summary, our results revealed that the SWFs to SYFs transition proceeds with pronounced changes in transcriptional profiles associated with angiogenesis, sex steroid biosynthesis and yolk deposition. The increased steroid hormone production likely enhances the capacity for yolk synthesis. Furthermore, the elevated vascularization in the theca layer of SYFs in coupled with a reduction in tight junctions may facilitate the transport of yolk precursors to access the follicles. - Source: PubMed
Publication date: 2026/05/01
Ma YanfenZhou ShuoMi YulingZhang Caiqiao - Fatty acid degradation (FAD) plays a crucial role in maintaining cellular energy homeostasis, with its dysfunction serves as an important pathological basis for the progression of various diseases. However, the specific regulatory mechanisms of this process in osteoarthritis (OA) remain to be further elucidated. This study aims to identify potential FAD-associated biomarkers and to investigate the role and potential mechanisms of FAD in OA. - Source: PubMed
Publication date: 2026/04/16
Li JianWei JinpengWu HuaHao Haihu - Immune checkpoint inhibitors like pembrolizumab exhibit variable efficacy in metastatic gastric cancer (GC). This study aimed to identify molecular drivers of pembrolizumab response, explore mechanisms of immune checkpoint inhibitors (ICIs) efficacy, and develop a prognostic signature. Transcriptomic analysis of pembrolizumab-treated GC (TIGER database) identified 165 response-associated differentially expressed genes (DEGs). Functional annotation and single-cell RNA sequencing (scRNA-seq) data from the Gene Expression Omnibus (GEO) revealed that responder-upregulated genes (R-DEGs) were enriched in immune activation pathways and mainly localized to CD8 + T/NK cells. In contrast, non-responder-upregulated genes (D-DEGs) were linked to extracellular matrix (ECM) remodeling and mainly expressed in fibroblasts/endothelial cells. CellChat analysis demonstrated that key DEGs mediate immune-stromal crosstalk via MHC-I and collagen/laminin signaling. A prognostic signature (Lasso-StepCox[forward] Riskscore; LSR: APOD, APOH, BATF2, GJA1, MAGED1, SLC5A1, SLCO2A1, VWF, VCAN) was derived and validated in four independent GC cohorts from the GEO and Cancer Genome Atlas (TCGA) database. Multi-omics analyses showed that LSR-high tumors exhibited aggressive clinicopathological features, increased stromal components, reduced cytotoxic immune infiltration, diminished tumor mutational burden (TMB), and poorer prognosis. Immunohistochemistry (IHC) and spatial transcriptomics in GC showed that stromal VWF/VCAN expression correlates with reduced CD8⁺ T cell granzyme B expression, suggesting T cell dysfunction. High VWF expression in GC predicted poor survival, and a combined VWF/VCAN score showed enhanced prognostic stratification. This study highlights stromal-immune crosstalk as a driver of pembrolizumab resistance and provides a signature as a clinical tool for prognosis and personalized therapy in metastatic GC. - Source: PubMed
Publication date: 2026/04/23
Zhang FanZhang QingqingShao ShuaiLi XiaoboCheng YiCao XuYu XiaotangGao Zhengming - Increasing evidence from preclinical models has linked the actions of brown adipose tissue (BAT) with protection against atherosclerosis and cardiovascular disease, in part due to its salutary effects on systemic lipid composition. However, human data on the role of BAT in atherosclerosis are scarce. - Source: PubMed
Publication date: 2026/04/30
Kulterer Oana CHerz Carsten TPils DietmarWollenweber TimFritzer-Szekeres MonikaKautzky-Willer AlexandraCalabretta RaffaellaHagn GerhardHacker MarcusGerner ChristopherHaug Alexander RKiefer Florian W