MULLER KAUFFMAN TETRATHIONATE BROTH BASE
- Known as:
- MULLER KAUFFMAN TETRATHIONATE BROTH BASE
- Catalog number:
- C1130
- Product Quantity:
- 500 grams
- Category:
- -
- Supplier:
- Condalab
- Gene target:
- MULLER KAUFFMAN TETRATHIONATE BROTH BASE
Related genes to: MULLER KAUFFMAN TETRATHIONATE BROTH BASE
- Gene:
- BPIFA4P NIH gene
- Name:
- BPI fold containing family A member 4, pseudogene
- Previous symbol:
- -
- Synonyms:
- BASE
- Chromosome:
- 20q11.21
- Locus Type:
- pseudogene
- Date approved:
- 2011-07-29
- Date modifiied:
- 2015-12-07
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- Many critical biological processes take place at hydrophobic:hydrophilic interfaces, and a wide range of organisms produce surface-active proteins and peptides that reduce surface and interfacial tension and mediate growth and development at these boundaries. Microorganisms produce both small lipid-associated peptides and amphipathic proteins that allow growth across water:air boundaries, attachment to surfaces, predation, and improved bioavailability of hydrophobic substrates. Higher-order organisms produce surface-active proteins with a wide variety of functions, including the provision of protective foam environments for vulnerable reproductive stages, evaporative cooling, and gas exchange across airway membranes. In general, the biological functions supported by these diverse polypeptides require them to have an amphipathic nature, and this is achieved by a diverse range of molecular structures, with some proteins undergoing significant conformational change or intermolecular association to generate the structures that are surface active. - Source: PubMed
Publication date: 2017/01/11
Sunde MargaretPham Chi L LKwan Ann H - The focus of this study is on the expression and regulation of the estrogen-regulated breast cancer and salivary gland expression (BASE) gene that may function as a breast cancer marker. In MCF7 cells, BASE is repressed by estrogen in an estrogen receptor alpha (ER alpha)-dependent manner. Promoter analysis of the BASE gene led to the identification of a 2-kb upstream enhancer that harbors binding sites for ER alpha and FoxA1. The recruitment of both ER alpha and FoxA1 to this region was shown by chromatin immunoprecipitation analysis. Furthermore, mutation studies and knockdown experiments show a clear separation between gene expression mediated by FoxA1 and ER alpha-dependent gene regulation. Additionally, we provide information on BASE expression in human breast tumor samples. - Source: PubMed
Bretschneider NancyBrand HeikeMiller NicolaLowery Aoife JKerin Michael JGannon FrankDenger Stefanie - To identify unknown membrane proteins that could be used as targets for breast and prostate cancer immunotherapies and secreted proteins to be used as diagnostic markers, a cDNA library was generated from membrane-associated polyribosomal RNA derived from four breast cancer cell lines, one normal breast cell line, and a prostate cancer cell line. The membrane-associated polyribosomal cDNA library was subtracted with RNA from normal brain, liver, lung, kidney, and muscle. Of the 15,581 clones sequenced from the subtracted cDNA library, sequences from 10,506 clones map to known genes, but 5,075 sequences, representing 3,181 unique transcripts, are not associated with known genes. As one example, we experimentally investigated expression of a previously uncharacterized breast cancer gene that encodes a secreted protein designated BASE (breast cancer and salivary gland expression). BASE is expressed in many breast cancers but not in essential normal tissues including the five organs used for subtraction. Further analysis of this library should yield additional gene products of use in the diagnosis or treatment of breast or prostate cancer. - Source: PubMed
Publication date: 2003/01/21
Egland Kristi AVincent James JStrausberg RobertLee ByungkookPastan Ira