Human IGFBP-3
- Known as:
- Human IGFBP-3
- Catalog number:
- BP3BU100
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Gropep Bioreagents
- Gene target:
- Human IGFBP-3
Related genes to: Human IGFBP-3
- Gene:
- IGFBP3 NIH gene
- Name:
- insulin like growth factor binding protein 3
- Previous symbol:
- -
- Synonyms:
- IBP3, BP-53
- Chromosome:
- 7p12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-09
- Date modifiied:
- 2019-04-23
- Gene:
- LRP1 NIH gene
- Name:
- LDL receptor related protein 1
- Previous symbol:
- APR, A2MR, IGFBP3R1, IGFBP-3R
- Synonyms:
- LRP, CD91, LRP1A, APOER
- Chromosome:
- 12q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-21
- Date modifiied:
- 2018-04-24
Related products to: Human IGFBP-3
Related articles to: Human IGFBP-3
- In addition to its important role in the regulation of somatic growth by acting as the major circulating transport protein for the insulin-like growth factors (IGFs), IGF binding protein-3 (IGFBP-3) has a variety of intracellular ligands that point to its function within major signaling pathways. The discovery of its interaction with the retinoid X receptor has led to the elucidation of roles in regulating the function of several nuclear hormone receptors including retinoic acid receptor-α, Nur77 and vitamin D receptor. Its interaction with the nuclear hormone receptor peroxisome proliferator-activated receptor-γ is believed to be involved in regulating adipocyte differentiation, which is also modulated by IGFBP-3 through an interaction with TGFβ/Smad signaling. IGFBP-3 can induce apoptosis alone or in conjunction with other agents, and in different systems can activate caspases -8 and -9. At least two unrelated proteins (LRP1 and TMEM219) have been designated as receptors for IGFBP-3, the latter with a demonstrated role in inducing caspase-8-dependent apoptosis. In contrast, IGFBP-3 also has demonstrated roles in survival-related functions, including the repair of DNA double-strand breaks through interaction with the epidermal growth factor receptor and DNA-dependent protein kinase, and the induction of autophagy through interaction with GRP78. The ability of IGFBP-3 to modulate the balance between pro-apoptotic and pro-survival sphingolipids by regulating sphingosine kinase 1 and sphingomyelinases may be integral to its role at the crossroads between cell death and survival in response to a variety of stimuli. The pleiotropic nature of IGFBP-3 activity supports the idea that IGFBP-3 itself, or pathways with which it interacts, should be investigated as targets of therapy for a variety of diseases. - Source: PubMed
Baxter Robert C