KCNJ11 Peptide
- Known as:
- KCNJ11 Peptide
- Catalog number:
- 46-680P
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- KCNJ11 Peptide
Related genes to: KCNJ11 Peptide
- Gene:
- KCNJ11 NIH gene
- Name:
- potassium voltage-gated channel subfamily J member 11
- Previous symbol:
- -
- Synonyms:
- Kir6.2, BIR
- Chromosome:
- 11p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-09-12
- Date modifiied:
- 2018-03-06
Related products to: KCNJ11 Peptide
Related articles to: KCNJ11 Peptide
- Ovarian cancer (OC) comprises multiple histotypes with distinct mechanisms, molecular features, and clinical behavior. We used Mendelian randomization (MR) to map histotype-stratified metabolic pathways and connect them to drug targets, establishing a translatable target-metabolic node-histotype risk chain. We built a multi-stage MR framework using Integrative Epidemiology Unit (IEU) OpenGWAS summary statistics. After screening 1400 plasma metabolites against overall ovarian cancer in UK Biobank and Ovarian Cancer Association Consortium (OCAC) with KEGG enrichment, we traced a prespecified amino acid/energy-nitrogen axis using histotype-stratified univariable MR and pathway-restricted multivariable MR. We then performed cis drug-target MR for , , , and , integrated triangulation, colocalization, and mediation analyses, and experimentally interrogated the prioritized -lactate-invasive mucinous ovarian cancer (IMOC) triangle. Screening nominated 55 and 72 metabolites in UK Biobank and OCAC, respectively (IVW < 0.05), highlighting amino-acid nitrogen and central-carbon metabolism. Univariable Mendelian randomization (UVMR) showed marked heterogeneity: alanine increased low-grade serous ovarian cancer (LGSOC) risk, glutamate was protective for endometrioid OC, and lactate-related traits most consistently implicated the low-grade/borderline serous lineage. In multivariable Mendelian randomization (MVMR), tryptophan and lactate levels emerged as independent risk nodes for serous low-grade plus low malignant potential (LG + LMP). Drug-target MR prioritized as protective (OR = 0.18) and as risk-increasing (OR = 7.50) for IMOC, with opposite target → lactate effects supporting a directionally symmetric target-lactate-IMOC triangle. Experimental perturbation in mucinous ovarian cancer models produced concordant reciprocal changes in lactate and malignant phenotypes, extending this triangle biologically. This integrative MR framework delineates histotype-specific metabolic drivers and links them to actionable targets, providing a roadmap from genetic prioritization to mechanistic and translational validation. - Source: PubMed
Publication date: 2026/06/02
Wang XinqiWang HaoyuHu SiyuanZhang WenyiChen HuiyuShen YingXue HongyangHong Li - Type 2 Diabetes Mellitus (T2DM) and various antidiabetic medications have been linked to the incidence and mortality of pneumonia, yet the causality remains unclear. This Mendelian Randomization (MR) study aimed to evaluate the potential causal relationships between them. - Source: PubMed
Publication date: 2026/05/19
Lin SiyiXu HongxiaXia JingyanXu Feng - We present a case report of an infant diagnosed with a pathogenic de novo variant in Potassium Inwardly Rectifying Channel Subfamily J Member 11), associated with both transient and permanent neonatal diabetes. This patient is one of the earliest diagnosed and genetically confirmed patients with neonatal diabetes. Early detection is key, and this case report emphasizes the need for early consideration of rapid whole-genome sequencing as an option for diagnosis to significantly improve patient outcomes. - Source: PubMed
Publication date: 2026/04/30
O'Connell KristinaNadernejad ClaudiaBupp CalebDewoolkar Aditya - To identify and characterise genetic variants associated with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) through whole-exome sequencing (WES), using the ClinVar database as the primary resource for variant evaluation. - Source: PubMed
Shabbir AsmaKhatoon AmbrinaAbbas ZaighamMirza Talat - A substantial proportion of individuals with a well-defined monogenic disorder remain without a genetic diagnosis. Low-level mosaic pathogenic variants are recognised as an underappreciated cause of monogenic disease but are technically challenging to detect, particularly in organ-specific conditions when affected tissue is inaccessible. - Source: PubMed
Publication date: 2026/05/25
Bennett Jasmin JLaver Thomas WMännistö Jonna M EHoughton Jayne A LDe Franco ElisaKalyon OguzhanWright SabrinaJohnson Anna-MarieDe Leon Diva DGloba EvgeniaKummer SebastianBanerjee IndraneelDastamani Antonia Wakeling Matthew NJohnson Matthew BFlanagan Sarah E