STC2 Recombinant Protein
- Known as:
- STC2 Recombinant Protein
- Catalog number:
- XW-RP3259
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- STC2 Recombinant Protein
Related genes to: STC2 Recombinant Protein
- Gene:
- STC2 NIH gene
- Name:
- stanniocalcin 2
- Previous symbol:
- -
- Synonyms:
- STC-2
- Chromosome:
- 5q35.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-07
- Date modifiied:
- 2015-08-26
Related products to: STC2 Recombinant Protein
Related articles to: STC2 Recombinant Protein
- Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are effective in treating NSCLC with EGFR mutations, the development of resistance limits their long-term efficacy. Autophagy has been implicated as a potential mechanism behind this acquired resistance. This study aims to investigate the role of Stanniocalcin 2 (STC2) in mediating autophagy and its contribution to EGFR TKI resistance. - Source: PubMed
Liu Yi-NanChen Yi-LingTsai Meng-FengWu Shang-GinChang Tzu-HuaTsai Tzu-HsiuShih Jin-Yuan - Osteosarcoma (OS) is an aggressive bone malignancy with a poor prognosis. Dysregulated calcium homeostasis may contribute to OS progression. - Source: PubMed
Publication date: 2026/04/16
Yao KangJiawei QianJietao XuXijun WangHong ZhouQing BiJun Lv - Mature cow weight (MWT), height (MHT), and body condition score (BCS) are economically important traits that significantly influence cowherd profitability by affecting maintenance feed requirements, which is the largest component of production costs. This study aimed to identify genomic regions, candidate genes, and pleiotropic variants associated with mature cow size traits in American Angus cattle, and to characterize their related gene ontology terms and metabolic pathways. The dataset provided by the American Angus Association comprised 434,746 MWT records from 222,907 animals; 213,875 MHT records from 112,987 animals; and 382,156 BCS records from 209,696 animals. Of these, 45,606 cows were genotyped and imputed to a common marker density of 54,609 markers. A final dataset of 51,410 SNPs from 45,452 animals remained after quality control for further analyses. The single-step genome-wide association study (ssGWAS) method was used in the analyses. Significant associations for mature cow size were detected on BTA7, BTA14, and BTA20, overlapping with previously reported QTLs for growth, feed efficiency, and carcass traits. Candidate genes such as , , , , , and were found to be related to muscle development, skeletal growth, lipid metabolism, and energy regulation. The genes , , , , , , , , , , and emerged as candidate genes exhibiting pleiotropic effects on mature cow size traits. Pathway enrichment highlighted the roles of insulin/IGF1R signaling, fibroblast growth factor receptors cascades, and mitogen-activated protein kinase pathways in MWT and MHT, while for BCS, only RHOD GTPase cycle was enriched. Pleiotropy-based analysis of regions affecting mature cow size traits identified shared genomic loci, and subsequent pathway analysis revealed G protein signaling as a common regulatory mechanism linking energy balance, adiposity, and growth. These results contribute to a better understanding of the genomic regions associated with mature cow size traits in Angus cattle. - Source: PubMed
Publication date: 2026/04/06
Ojo Ayooluwa OMulim Henrique ACampos Milena A FGarcia AndréRetallick-Riley KelliFonseca Pablo A SOliveira Hinayah R - Stem cell-derived insulin-producing cells (Ins-PCs) hold great promise for diabetes treatment. Placenta-derived multipotent stem cells (PMSCs) are considered an ideal source of Ins-PC generation due to their immunomodulatory and differentiation properties. However, the cellular and molecular pathways underlying PMSC differentiation to Ins-PCs have not been fully elucidated. In this study, PMSCs were isolated from human placenta and successfully differentiated into Ins-PCs using miRNA-181a mimics. Differentiated Ins-PCs produced a significant amount of insulin and upregulation of C-peptide, insulin, and MAFA expression, compared to undifferentiated control PMSCs. RNA sequencing and LC-MS/MS were performed to uncover the pathways involved in the Ins-PC differentiation process. RNA sequencing revealed the transcriptional landscape of PMSC-derived Ins-PC differentiation. Pathway analysis identified important pathways involved in the differentiation process, including Notch and Wnt/ß-catenin, and so forth. Proteomics analysis further affirmed the presence of key insulin pathway-related proteins involved in the differentiation of PMSCs into Ins-PCs, including LEPR, STC2, MAP2K2, and so forth. Moreover, integrated transcriptomic and proteomic analyses further highlighted LEPR as a potential key regulator for Ins-PC differentiation. These findings demonstrated the feasibility of generating Ins-PCs from PMSCs and identified potential signaling pathways and regulators underlying Ins-PC differentiation, supporting PMSCs as a promising stem cell source of cell-based therapy for diabetes treatment. - Source: PubMed
Publication date: 2026/04/01
Xu JieShen XingguiGu YangLewis David FZoorob DaniWang Yuping - While growing evidence highlights the significance of metabolic reprogramming in colorectal cancer (CRC), the exact mechanisms behind these changes remain unclear. This study sought to identify key metabolic regulators and clarify their downstream pathways in CRC progression. - Source: PubMed
Publication date: 2026/03/17
Jiang JunZhang XiaohongYe FangzhouQian PeiyuLi FanLi HuanqingFeng Li