CLIC3 Recombinant Protein
- Known as:
- CLIC3 Recombinant Protein
- Catalog number:
- XW-RP3046
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- CLIC3 Recombinant Protein
Related genes to: CLIC3 Recombinant Protein
- Gene:
- CLIC3 NIH gene
- Name:
- chloride intracellular channel 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-19
- Date modifiied:
- 2015-09-07
Related products to: CLIC3 Recombinant Protein
Related articles to: CLIC3 Recombinant Protein
- The extracellular matrix (ECM) plays a critical role in the tumor microenvironment (TME). However, the prognostic relevance of matrisome-related genes (MRGs) in bladder cancer (BLCA) remains poorly understood. This study aimed to establish a matrisome-related gene signature for prognostic stratification in bladder cancer and to further characterize its associations with tumor microenvironmental features and candidate compounds. - Source: PubMed
Publication date: 2026/04/20
Wu GongpingYu WeitaoYao DongnuanMa XuemingFan ChengweiHou JuanjuanRen XuezhaoTian Junqiang - Terminal erythroid differentiation involves dramatic cellular remodeling that culminates in the expulsion of the nucleus, a process known as enucleation. While enucleation is conserved across mammals and is crucial for the generation of fully functional erythrocytes, the mechanisms governing this process have remained largely unknown, in part because the absence of genetic material in mature, enucleated red blood cells hinders genetic experimentation. Here, we performed a pooled, forward-genetic CRISPR-Cas9 screen in enucleated red blood cells derived from primary human hematopoietic stem cells to identify genes required for enucleation. We found that Chloride Intracellular Channel 3 (CLIC3) and Vesicle-associated membrane protein 8 (VAMP8) are both necessary for terminal erythroid differentiation, yet likely act through different mechanisms. Knockdown of CLIC3 led to a delay in erythroblast differentiation, culminating in impaired enucleation. We found that the knockdown cells had increased p53 and p21 and exhibited cell cycle alterations, suggesting CLIC3 plays a crucial role in coordinating cell cycle progression during erythropoiesis. In comparison, VAMP8-depleted cells initially appear to undergo accelerated differentiation but then display a specific defect in enucleation. Transcriptional analysis of the VAMP8-knockdown cells suggested dysregulation of pathways for vesicle trafficking and actin binding, and imaging of late-stage erythroblasts revealed impaired nuclear polarization and disorganized actin. This work provides a new approach for functional genomics in enucleated cells and reveals novel factors important for terminal erythroid differentiation and enucleation. - Source: PubMed
Publication date: 2026/04/07
Tetard MarilouLin TianjianPeterson Nana AGullberg Rebekah CLe Guen YannDoench John GEgan Elizabeth S - Pancreatic Cancer (PC) is a highly aggressive malignancy with a dismal prognosis, primarily due to late-stage diagnosis and limited therapeutic options. This study aimed to identify potential biomarkers involved in PC progression and immune microenvironment modulation. - Source: PubMed
Publication date: 2026/04/18
Dong ChangjunGuan JingDong LinhuanYu YunlinZhang XiangweiLi ZhengZhang XianlinMo Chunlin - - Source: PubMed
Publication date: 2026/04/03
Mellor PaulSmith Shari EKendall StephanieKyrylenko LiliiaMonzer AlissarSaxena AnuragGoubran FarahAnderson Deborah H - The allergen-induced late-phase asthmatic response (LAR) is used to study the mechanisms and treatment of asthma. We hypothesized that gene-expression (mRNA) biomarkers of the LAR may predict asthma exacerbations and severity. - Source: PubMed
Publication date: 2026/04/03
Zhang MingmingKim Young WoongYang Chen XiGauvreau Gail MFitzGerald John MarcusBoulet Louis-PhilippeO'Byrne Paul MTebbutt Scott JSingh Amrit