C1orf41 Recombinant Protein
- Known as:
- C1orf41 Recombinant Protein
- Catalog number:
- XW-RP3026
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- C1orf41 Recombinant Protein
Related genes to: C1orf41 Recombinant Protein
- Gene:
- HSPB11 NIH gene
- Name:
- heat shock protein family B (small) member 11
- Previous symbol:
- C1orf41
- Synonyms:
- HSPCO34, PP25, IFT25
- Chromosome:
- 1p32.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-24
- Date modifiied:
- 2016-10-05
Related products to: C1orf41 Recombinant Protein
Related articles to: C1orf41 Recombinant Protein
- Oil spills pose significant ecological risks to marine benthic organisms, particularly bivalves. In this study, Ruditapes philippinarum was exposed to different concentrations of crude oil water accommodated fraction (WAF) and chemical enhanced water accommodated fraction (CEWAF) prepared with the addition of an oil dispersant. Six exposure groups were established: low (5 %), medium (10 %), and high (40 %) concentrations for both WAF and CEWAF treatments. Mortality analysis revealed that, at the same nominal concentrations, cumulative mortality in the M-CEWAF and H-CEWAF groups was significantly higher than in the corresponding M-WAF and H-WAF groups (P < 0.05). Histological examination showed more severe tissue damage in CEWAF groups, including vacuolization, structural disintegration, and cellular loss in the hepatopancreas and gills. Biochemical assays indicated prolonged oxidative stress in CEWAF groups, as evidenced by sustained elevations of CAT, GST, and MDA levels. Transcriptome analysis identified several upregulated stress-responsive genes involved in antioxidant defense (PHGDH), detoxification (CYP2J2, ABCC1), environmental stress (Dio1), and cellular protection (HspB11). The expression levels of PHGDH, Dio1, CYP2J2, and ABCC1 were significantly elevated under both WAF and CEWAF exposures (P < 0.05), showing a general pattern of early activation followed by a gradual decline over time. HspB11 exhibited dose-dependent upregulation, particularly under CEWAF exposure, indicating a prolonged activation of cellular protective mechanisms during the late exposure phase. These results demonstrate that CEWAF exposure induces stronger toxicological and transcriptomic responses than WAF, and that oxidative biomarkers and gene expression profiles are effective tools for evaluating the ecological risks of chemically dispersed oil. - Source: PubMed
Publication date: 2025/10/31
Gao YangNie Hongtao - This study investigates the role of HSPB1 in pancreatic cancer, particularly its impact on cell proliferation and migration through ferroptosis regulation and interaction with TP53 MATERIALS AND METHODS: HSPB1 expression was analyzed using BioGPS and GEPIA databases. BxPC-3 cell lines with stable HSPB1 overexpression and knockdown were created via plasmid transfection and siRNA. The study examined HSPB1's effect on TP53 protein levels and its role in ferroptosis using TP53 agonists and inhibitors. - Source: PubMed
Publication date: 2025/06/12
Tian ZeyuLiu QiLuo JihuiNing NingQu Jing - Cellular senescence (CS) is a hallmark of Alzheimer's disease (AD). However, the mechanisms through which CS contributes to AD pathogenesis remain poorly understood. We found that CS level in AD was higher compared with the healthy control group. Transcriptome-based differential expression analysis identified 113 CS-related genes in blood and 410 in brain tissue as potential candidate genes involved in AD. To further explore the causal role of these genes, an integrative mendelian randomization analysis was conducted, combining AD genome-wide association study summary statistics with expression quantitative trait loci (eQTL) and DNA methylation quantitative trait loci (mQTL) data from blood samples, which identified five putative AD-causal genes (CENPW, EXOSC9, HSPB11, SLC44A2, and SLFN12) and 18 corresponding DNA methylation probes. Additionally, integrative analysis between eQTLs and mQTLs from blood uncovered two genes and 12 corresponding regulatory elements involved in AD. Furthermore, two genes (CDKN2B and ITGAV) were prioritized as putative causal genes in brain tissue and were validated through in vitro experiments. The multi-omics integration study revealed the potential role and underlying biological mechanisms of CS driven by genetic predisposition in AD. This study contributed to fundamental understanding of CS in AD pathogenesis and facilitated the identification of potential therapeutic targets for AD prevention and treatment. - Source: PubMed
Xu YudiLiu ShutongZhou ZhaokaiQin HongzhuoZhang YuyuanZhang GeMa HongxuanHan XinweiLiu HuiminLiu Zaoqu - Alpaca (Vicugna pacos), llama (Lama glama), vicugna (Vicugna vicugna) and guanaco (Lama guanicoe), are the camelid species distributed over the Andean high-altitude grasslands, the Altiplano, and the Patagonian arid steppes. Despite the wide interest on these animals, most of the loci under selection are still unknown. Using whole-genome sequencing (WGS) data we investigated the occurrence and the distribution of Runs Of Homozygosity (ROHs) across the South American Camelids (SACs) genome to identify the genetic relationship between the four species and the potential signatures of selection. - Source: PubMed
Publication date: 2023/08/21
Pallotti StefanoPicciolini MatteoAntonini MarcoRenieri CarloNapolioni Valerio - Animals of different regions have adapted to adverse environmental conditions by modifying their phenotypic and genotypic characteristics in the long run. - Source: PubMed
Publication date: 2023/08/02
Rezvannejad ElhamMousavizadeh SeyedAzim