SLC12A2 / NKCC1 Antibody
- Known as:
- SLC12A2 / NKCC1 Antibody
- Catalog number:
- 71-134
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- SLC12A2 / NKCC1 Antibody
Related genes to: SLC12A2 / NKCC1 Antibody
- Gene:
- SLC12A2 NIH gene
- Name:
- solute carrier family 12 member 2
- Previous symbol:
- -
- Synonyms:
- NKCC1, BSC, BSC2, PPP1R141
- Chromosome:
- 5q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-02-16
- Date modifiied:
- 2016-02-17
Related products to: SLC12A2 / NKCC1 Antibody
Related articles to: SLC12A2 / NKCC1 Antibody
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Lozano-Esparza SusanaShakt Gabrielle EBrody Jennifer AMartinez-Perez AngelConomos Matthew PGermain MarineClapham Katharine RTeder-Laving Marisvan Hylckama Vlieg AstridKauko AnniThibord FlorianBezerra Ohanna C LNadkarni GirishMunsch GaëlleNøst Therese HaugdahlGoode Ellen LJi YuekaiChasman Daniel IReiner Alexander PTurman ConstanceWiggins Kerri LSitlani Colleen MSouto Juan CarlosLutsey Pamela LBellomo TiffanyBiobank EstonianProgram Million VeteranLi-Gao RuifangWinstén Aleksi KristianFinnGen Chen Ming-HueiDo RonGourhant LénaickHveem KristianArmasu Sebastian MSaut NoémiePankratz NathanGiulianini FrancoHaessler JeffreySong MingyangOlaso RobertBoerwinkle EricDochtermann DanielSoria Jose ManuelRich Stephen SSmadja DavidKoyama SatoshiRosendaal Frits RNiiranen TeemuGagnon FranceMy T Vy HaZakai NeilLemarie CatherineSkogholt Anne HeidiDeleuze Jean-FrançoisPankow James SRidker Paul MLiu YuxiRice Ken MPyarajan SaijuCushman MaryEmmerich JospehPsaty Bruce MNatarajan PradeepJohnson Andrew DRodger Marc ASuchon PierreCouturaud FrancisMorange Pierre-EmmanuelTang WeihongKooperberg CharlesKabrhel ChristopherSabater-Lleal MariaTrégouët David-AlexandreWolberg Alisa SDamrauer Scott MSmith Nicholas L - Prenatal ethanol (alcohol) exposure (PreEE) results in abnormal tangential migration of medial ganglionic eminence (MGE)-derived GABAergic interneurons (GINs) in the embryonic mouse medial prefrontal cortex (mPFC); later in life, this is associated with impaired behavioral flexibility commonly seen in fetal alcohol spectrum disorders (FASD). The PreEE-induced abnormal tangential migration involves, in part, ethanol potentiating GABA receptor-mediated depolarization, the latter due to elevated intracellular chloride sustained primarily by the Na-K-Cl cotransporter NKCC1 in embryonic GINs. We previously reported that coincident administration of the NKCC1 antagonist bumetanide with PreEE prevents the PreEE-induced aberrant migration of GINs in the mPFC. However, such simultaneous dispensing rarely occurs in real life. In this light, the present study assessed whether bumetanide administered after PreEE mitigates the PreEE-induced aberrant tangential migration. - Source: PubMed
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