RNF144B [4F1] Monoclonal Antibody
- Known as:
- RNF144B [4F1] Monoclonal Antibody
- Catalog number:
- 51-606
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- RNF144B [4F1] Monoclonal Antibody
Related genes to: RNF144B [4F1] Monoclonal Antibody
- Gene:
- CAMSAP1 NIH gene
- Name:
- calmodulin regulated spectrin associated protein 1
- Previous symbol:
- -
- Synonyms:
- FLJ31228, DKFZp434F195
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-09
- Date modifiied:
- 2016-11-11
- Gene:
- CFAP97 NIH gene
- Name:
- cilia and flagella associated protein 97
- Previous symbol:
- KIAA1430
- Synonyms:
- DKFZp434F1728, hmw
- Chromosome:
- 4q35.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-21
- Date modifiied:
- 2018-11-15
- Gene:
- CYP4F30P NIH gene
- Name:
- cytochrome P450 family 4 subfamily F member 30, pseudogene
- Previous symbol:
- C2orf14
- Synonyms:
- DKFZp434F1719, 4F-se9[6:7:8]
- Chromosome:
- 2q21.1
- Locus Type:
- pseudogene
- Date approved:
- 2004-01-09
- Date modifiied:
- 2015-12-09
- Gene:
- FSCB NIH gene
- Name:
- fibrous sheath CABYR binding protein
- Previous symbol:
- C14orf155
- Synonyms:
- DKFZP434F1017
- Chromosome:
- 14q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-11
- Date modifiied:
- 2016-10-05
- Gene:
- GPATCH4 NIH gene
- Name:
- G-patch domain containing 4
- Previous symbol:
- GPATC4
- Synonyms:
- FLJ20249, DKFZP434F1735
- Chromosome:
- 1q22-q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-12-01
- Date modifiied:
- 2018-02-13
Related products to: RNF144B [4F1] Monoclonal Antibody
Related articles to: RNF144B [4F1] Monoclonal Antibody
- Major depressive disorder (MDD) is a prevalent mental illness, and inflammatory processes are considered a pivotal component of the pathogenesis of MDD. This study aims to identify novel biomarkers associated with the development of MDD and to elucidate the underlying immunological mechanisms. - Source: PubMed
Publication date: 2026/04/30
Wu XinyuZhou ShaomingYang PingChen JiayiLiu HonghuaShi LuZhang Xuehua - - Source: PubMed
Publication date: 2026/04/15
Hu YuxinChen LuSha JianmeiShao CaihongGao JunliYao Jianhua - Lung adenocarcinoma (LUAD) is a highly heterogeneous malignancy with poor clinical outcomes, underscoring the urgent need for robust prognostic biomarkers and therapeutically tractable regulatory molecules. Long non-coding RNAs (lncRNAs) have emerged as key modulators of tumor progression and immune regulation; however, the prognostic and functional significance of TMPO-AS1 in LUAD remains largely unexplored. - Source: PubMed
Publication date: 2026/04/13
Nirmal SakshiSaini ChainseeBaweja BhavikaVats PrernaPatidar PrachiJangir KritikaNema Rajeev - Stroke, as a predominant cerebrovascular event, is characterized by disproportionately high morbidity, disability, and mortality rates. The central role of neuroinflammation in its pathophysiology underscores the clinical significance of modulating related regulatory pathways. Notably, ring finger protein 144B (RNF144B), an E3 ubiquitin ligase with demonstrated anti-inflammatory properties, presents a potential novel therapeutic target. Herein, we aimed to rigorously investigate RNF144B's involvement in stroke pathogenesis and delineate its mechanistic underpinnings. RNF144B knockout (KO) and wild-type (WT) C57BL/6 male mice were subjected to middle cerebral artery occlusion (MCAO) to mimic ischemic stroke. Co-immunoprecipitation, immunofluorescent staining, western blot, RT-PCR were used to investigate the function and mechanism of RNF144B during MCAO. RNF144B expression was significantly upregulated following cerebral ischemic stroke. The absence of RNF144B promotes microglial activation and polarization, exacerbating neuroinflammatory responses. Mechanistically, RNF144B interacts with and promotes the K48-linked ubiquitination of Tumor necrosis factor receptor (TNFR)-associated factor 3 (TRAF3), leading to its proteasomal degradation. The absence of RNF144B stabilizes TRAF3, thereby enhancing the activation of NF-κB and MAPK signaling pathways. Importantly, TRAF3 knockdown in RNF144B-deficient mice partially reversed the detrimental effects on neurological function, microglial activity, and neuroinflammation post-MCAO. The absence of RNF144B exacerbates stroke-induced neuroinflammation through TRAF3 stabilization, revealing this E3 ubiquitin ligase as a potential therapeutic target for cerebral ischemia. - Source: PubMed
Publication date: 2026/03/27
Hu DianboZhao ShuhuiJin YuetingYang ChenHu YugangLiu QianMa Renzheng - Major depressive disorder (MDD) is a serious neuropsychiatric disorder. While emerging evidence suggests that PANoptosis may play a role in MDD pathogenesis, the precise involvement of PANoptosis-related genes remains unclear. - Source: PubMed
Publication date: 2025/10/02
Zhang HuanHuang NaMa XinxinLiu Yanan