ETV6 antibody
- Known as:
- ETV6 (anti-)
- Catalog number:
- orb48366
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- ETV6 antibody
Related genes to: ETV6 antibody
- Gene:
- ETV6 NIH gene
- Name:
- ETS variant 6
- Previous symbol:
- -
- Synonyms:
- TEL
- Chromosome:
- 12p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-28
- Date modifiied:
- 2019-04-23
Related products to: ETV6 antibody
Related articles to: ETV6 antibody
- Aberrant DNA methylation is a hallmark of acute myeloid leukemia (AML) and contributes to leukemogenesis, treatment response, and clinical heterogeneity. While genome-wide methylation studies have identified prognostic methylation signatures, the impact of DNA methylation within pharmacologic pathways and AML-relevant disease genes remains incompletely understood. We investigated the association of DNA methylation in genes of pharmacokinetic/pharmacodynamic (PK/PD) pathways of drugs used to treat AML and in myeloid leukemia-related genes with treatment outcomes in pediatric AML. - Source: PubMed
Publication date: 2026/07/31
Alshameri NaifahMarchi FranciscoCao XueyuanRubnitz Jeffrey ERibeiro Raul CMeshinchi SoheilPounds Stanley BLamba Jatinder K - The aim was to explore the clinical characteristics, diagnostic methods and prognosis of Myelodysplastic Syndromes (MDS) accompanied by eosinophilia and basophilia. - Source: PubMed
Gao JianjunQi JunjuanLi RuiminZhang Xiaofang - Systemic inflammatory manifestations caused by hematologic malignancies may be very similar to autoimmune diseases, making diagnosis difficult. Acute monocytic leukemia (AML-M5) is characterized by significant cytokine production and, in rare cases, can mimic large vessel vasculitis (LVV). - Source: PubMed
Publication date: 2026/07/23
Nie LiuyanWang HongliShen NingHan Yongmei - Reliable detection of structural variants (SVs) and copy number variations (CNVs) is crucial in the contemporary diagnostics of pediatric B-cell acute lymphoblastic leukemia (B-ALL). However, limitations of commonly used conventional and molecular cytogenetic methods may hinder the accurate genetic characterization of patients. Optical genome mapping (OGM) offers a reliable alternative by enabling high-resolution, genome-wide detection of CNVs and SVs. Chromosomal aberrations were screened using OGM in 51 children with B-ALL. The results were compared with those of karyotyping, fluorescence in situ hybridization (FISH), digital multiplex ligation-dependent probe amplification (digitalMLPA), and targeted RNA sequencing (RNA-seq). OGM data showed high congruency with karyotyping and FISH findings, detecting clinically relevant variants beyond G-banding results and unraveling a complex KMT2A fusion undetected by FISH. Gene fusions involved in complex ETV6::RUNX1 translocations, but not detected by RNA-seq, were confirmed using FISH. Normalization of OGM copy number values with DNA-index-improved concordance with FISH-derived copy numbers in near-tri/tetraploid cases. In the peripheral regions of OGM variants (fringe-zones), a novel evaluation strategy called 'FriZone' was applied, which significantly improved the concordance between OGM and digitalMLPA. In addition, a co-segregation analysis revealed strong associations between ETV6::RUNX1 fusion and deletions of ETV6, RAG2, and NR3C2. OGM uncovered complex rearrangements undetected by widely used methods in 15% of cases, improving genetic classification and risk stratification in 10% of the patients. The FriZone analysis and normalization by DNA-index provide a refined, more accurate approach to OGM variant interpretation, facilitating the efficient application of OGM in clinical diagnostics. © 2026 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. - Source: PubMed
Publication date: 2026/08/05
Bekő AnnaPéterffy BorbálaHughes AlexJakab Janka SáraHaltrich IrénÁrvai Kristóf BalázsBedics GáborCsonka KatalinPapp GergőKapczár DóraBohusné Barta Bettina ArankaHegyi Lajos LászlóSzalóki GáborBarna GáborMatolcsy AndrásEgyed BálintHevessy ZsuzsannaBenard-Slagter AnnePalit SanderSavola SuviBödör CsabaAlpár Donát - - Source: PubMed
Liang J YZhao JWang C YChen JYao H HYang W H