FOXM1 antibody (Biotin)
- Known as:
- FOXM1 (anti-) (Biotin)
- Catalog number:
- orb114129
- Product Quantity:
- 100 ul
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- FOXM1 antibody (Biotin)
Related genes to: FOXM1 antibody (Biotin)
- Gene:
- FOXM1 NIH gene
- Name:
- forkhead box M1
- Previous symbol:
- FKHL16
- Synonyms:
- HFH-11, trident, HNF-3, INS-1, MPP2, MPHOSPH2, TGT3
- Chromosome:
- 12p13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-25
- Date modifiied:
- 2016-10-05
Related products to: FOXM1 antibody (Biotin)
Related articles to: FOXM1 antibody (Biotin)
- The NLRP3 inflammasome is a multi-protein innate immune complex that functions as a critical sensor of cellular danger signals, yet its role in gynecological malignancies remains incompletely understood. This mini-review systematically evaluates the paradoxical functions of NLRP3 across the three major gynecological cancers-ovarian, endometrial, and cervical-with emphasis on its dual impact on the tumor immune microenvironment and immunotherapy response. In ovarian cancer, NLRP3 drives immune suppression through PD-L1 upregulation and M2 macrophage polarization via the USP19-STAT6 axis, while simultaneously enhancing cisplatin sensitivity through FTO-mediated pyroptotic signaling. In endometrial cancer, the ERRα-NLRP3-GSDMD pathway regulates pyroptosis in a molecular subtype-dependent manner, with pro-immune effects in MSI-H tumors but potentially pro-tumorigenic consequences in microsatellite-stable subtypes. In cervical cancer, HPV oncoproteins employ multiple mechanisms-including Foxm1-mediated transcriptional suppression, KIF23-dependent GSDMD blockade, and non-coding RNA regulation-to silence NLRP3 and evade immune surveillance. Beyond tumor type-specific mechanisms, the tumor-intrinsic PD-L1/NLRP3 axis has been identified as a key driver of resistance to anti-PD-1 immunotherapy across cancers, whereas NLRP3-activating nanovaccines and small-molecule agonists offer strategies to convert immunologically cold tumors into immunoresponsive ones. We further discuss combination approaches integrating NLRP3 modulators with immune checkpoint inhibitors and PARP inhibitors via the cGAS-STING-NLRP3 axis. Understanding the context-dependent functions of NLRP3 is essential for developing precision immunotherapeutic strategies tailored to tumor type, molecular subtype, and immune context in gynecological malignancies. - Source: PubMed
Publication date: 2026/06/24
He YiboWu ShiyueShou ZianGuo QianHong YaonanZhao LianfangWang Jie - Senescence-related transcriptional programs and epithelial-mesenchymal transition (EMT) are implicated in pancreatic ductal adenocarcinoma (PDAC) progression and therapy resistance. However, the single-cell distribution, functional heterogeneity, and clinical relevance of EMT-associated senescence-like programs remain incompletely defined. - Source: PubMed
Publication date: 2026/07/08
Chen Long-JiangWu LunChen Su-HangPan XuanShen Zheng-ChaoWang JieZhang ShuoZhai Lu-LuWang Xiao-Ming - Human iPSC-derived hepatocytes are widely used in disease modeling. However, late embryonic development in the human liver remains elusive, which hinders differentiation. During late liver embryonic development, Topoisomerase II (TOP2) is downregulated; however, its role in differentiation is unclear. We replicated the TOP2 silencing at birth and identified a transcription factor crucial for hepatocyte differentiation in vitro. Subtoxic inhibition of TOP2 reduces nuclear chromatin condensation without causing DNA damage. RNA-seq analysis revealed that TOP2 inhibition induced cell cycle arrest, accompanied by FOXM1 downregulation. ATAC-seq confirmed that TOP2A inhibition decreased chromatin accessibility and modulated the Wnt/β-catenin pathway. Proteomic analysis demonstrated that FOXM1 inhibition mimicked TOP2A-mediated cell cycle arrest and reduced the levels of fetal hepatocyte proteins. Prolonged FOXM1 inhibition results in increased hepatocyte polyploidization, enhanced CYP450 activity, and improved lipid metabolism. Our findings suggest that FOXM1 inhibition promotes terminal differentiation of human iPSC-derived hepatocytes, potentially paving the way for understanding late embryonic development in the human liver. - Source: PubMed
Publication date: 2026/07/08
Alves Telles-Silva KayquePacheco LaraKomatsu SabrinaChianca FernandaChagas GustavoCristine Martins GabriellyGridina MariaPanchenko DariaMelechco Carvalho ValdemirG Caldini EliaS Fishman VeniaminArkin MichelleGoulart ErnestoZatz Mayana - - Source: PubMed
Publication date: 2026/07/07
- Patients with advanced malignant adrenal tumors face poor prognoses with limited treatment options. Emerging data suggest that these rare tumors exhibit immunogenicity, potentially benefiting from intensified immunotherapy. - Source: PubMed
Publication date: 2026/07/06
Schultheiß ChristophBesemer BrendaWillscher EdithPaschold LisaMersceman TifannyTalpin AliceSerger ClaraZippelius AlfredBerruti AlfredoGrisanti SalvatoreMenke-van der Houven van Oordt Catharina WillemienBaudin EricLandwehr Laura-SophieCapdevila JaumeSubbiah VivekGranberg DanGedske Daugaard KirstenTriebig AlexandraGauduchon ThibaultDo Cao ChristineGarcia Marie-EveMagalhaes JoaoChêne LaurentBinder Mascha