FOXM1 antibody (Alkaline Phosphatase)
- Known as:
- FOXM1 (anti-) (Alkaline Phosphatase)
- Catalog number:
- orb113636
- Product Quantity:
- 100 ul
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- FOXM1 antibody (Alkaline Phosphatase)
Related genes to: FOXM1 antibody (Alkaline Phosphatase)
- Gene:
- FOXM1 NIH gene
- Name:
- forkhead box M1
- Previous symbol:
- FKHL16
- Synonyms:
- HFH-11, trident, HNF-3, INS-1, MPP2, MPHOSPH2, TGT3
- Chromosome:
- 12p13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-25
- Date modifiied:
- 2016-10-05
Related products to: FOXM1 antibody (Alkaline Phosphatase)
Related articles to: FOXM1 antibody (Alkaline Phosphatase)
- Hepatoblastoma (HB) ranks as the predominant primary malignant neoplasm affecting the pediatric liver, yet effective targeted therapies remain limited. Forkhead box M1 (FOXM1) is a pivotal oncogenic transcription factor overexpressed in multiple malignancies, but its role in HB metabolic reprogramming and the underlying mechanisms remain poorly understood. - Source: PubMed
Publication date: 2026/07/29
Zhang YuLiu Lu - Skin cutaneous melanoma (SKCM) is a highly aggressive malignancy with a poor prognosis, necessitating the exploration of novel molecular mechanisms driving its progression. CircRNA, which have emerged as critical regulators in cancer biology, have been implicated in various tumorigenic processes. However, their specific roles in SKCM remain inadequately understood. - Source: PubMed
Publication date: 2026/08/10
Yang RonghuaWang XiaoxiangZhuo JiananTang LingjieKang DeniLiu SirongLi JiehuaZhou Sitong - Adult mammalian cardiomyocytes exhibit limited regenerative capacity, which remains a major challenge for functional recovery after myocardial infarction (MI). Our previous study identified a cocktail of five small molecules (5SM) that promotes cardiomyocyte proliferation and heart regeneration; however, the complexity of this five-compound mixture poses significant barriers to clinical translation and mechanistic studies. Here, we identified a simplified dual-compound cocktail (2SM) composed of phenylephrine hydrochloride (PE) and harmine (HM), which also robustly enhanced cardiomyocyte proliferation in vitro and in vivo. Transcriptomic and metabolomic analyses indicated that 2SM treatment activated cardiomyocyte cell-cycle programs and metabolic reprogramming. PE activated a fetal program and contributed to the up-regulation of CCND1 and WEE1 by activating mTOR signaling pathway, thus enabling cardiomyocytes to enter the G1/S phase but not G2/M phase. HM inhibited DYRK1A and activated MMB and FOXM1-MuvB complex, resulting in the upregulation of G2/M phase gene expression, of which the upregulated CDC25 proteins dephosphorylate CDK1, thereby relieving the inhibitory effect of PE. Sequential treatment of PE followed by HM was essential for completion of cytokinesis. In summary, we identified that 2SM, two compounds of 5SM, reprogrammed cardiomyocytes into an embryonic-like state, and precisely coordinated cell cycle progression for promoting cardiomyocyte proliferation. - Source: PubMed
Publication date: 2026/08/11
Wang ZihaoZheng LixiaMa XiaokaiGao PengChen YuanyuanXiao ChengluZhao XinXiao ZhenyanZhu XiaojunZhang ZheXiong Jing-Wei - Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with limited treatment options. Although PARP inhibitor (PARPi) offers great promise in treating TNBC with deficiency in homologous recombination (HR), most TNBC patients are HR-proficient. Furthermore, acquired resistance to PARPi remains as a challenge. Thus, there is an unmet need to identify new therapeutic target for developing advanced TNBC treatment strategy. - Source: PubMed
Publication date: 2026/08/11
Chen Han-HsiunChang Keng-HaoLee Sin-RongChiu Chih-HaoYao Bing-YuCarissa TeraHsu Hung Shih-DuoKuo Wen-LingWang Lily Hui-ChingLi Chia-WeiHu Che-MingChen Hsin-YiChen Ruey-Hwa - Diffuse midline glioma (DMG) is a devastating pediatric brain tumor with an unmet need for novel therapies. Immune checkpoint inhibitors have failed to prolong survival of DMG patients. - Source: PubMed
Publication date: 2026/08/10
Tzaridis TheophilosFernández Ester CalvoEisemann TanjaLiou AngelaAndrade Augusto Fariade Biagi-Junior Carlos A OHope Jennifer LHewson Liam SMcNicholas MichaelDe Cola AntonellaPathania ManavBecher Oren JJabado NadaLarson Jon DBaker Suzanne JCalifano AndreaBagchi AnindyaGallitto MatthewHawkins CynthiaFilbin Mariella GBradley Linda MAdams Peter DPavisic JovanaWechsler-Reya Robert J