SERPINA3 antibody
- Known as:
- SERPINA3 (anti-)
- Catalog number:
- orb129738
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- SERPINA3 antibody
Related genes to: SERPINA3 antibody
- Gene:
- SERPINA3 NIH gene
- Name:
- serpin family A member 3
- Previous symbol:
- AACT
- Synonyms:
- ACT
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-04
Related products to: SERPINA3 antibody
Related articles to: SERPINA3 antibody
- Metabotropic glutamate receptors (mGluRs) are of increasing interest in the pathophysiology and treatment of schizophrenia. In the nucleus accumbens (NAc), presynaptic mGluRs (largely group II and III) can regulate the activity of medium spiny neurons (MSNs) through control of glutamate release from extra-striatal regions. Given that inflammatory pathways can modulate glutamate and dopamine signalling, inflammation may influence these mGluR-mediated mechanisms in schizophrenia. Cellular expression of mGluR mRNAs in the NAc was investigated using a publicly available single-nucleus RNA sequencing dataset. Frozen NAc tissue from individuals with schizophrenia (n = 30) and controls (n = 30) were obtained from the New South Wales Brain Tissue Resource Centre. Protein levels of glutamate receptors, mGluR2, mGluR3, mGluR4, mGluR7, and a dopamine synthesis enzyme, tyrosine hydroxylase (TH) were quantified by western blot. mGluR transcripts were measured using qRT-PCR. Neuroinflammatory status was determined from levels of pro-inflammatory transcripts (SERPINA3, IL6, IL1β, and TNFα). TH protein levels were elevated in the NAc of individuals with schizophrenia. GRM1, GRM3, GRM4, GRM7 and GRM8 transcripts were strongly expressed in MSNs and inhibitory neurons. Gene and protein expression of the mGluRs did not differ between schizophrenia and controls. When the cohort was stratified into a high (n = 13) and a low (n = 42) inflammation group, GRM1 and GRM5 mRNAs were decreased in those with high inflammation. These data indicate that elevated inflammation, irrespective of schizophrenia diagnosis, is associated with a selective reduction of group I mGluR transcripts in the NAc. This suggests that inflammation may be a key modulator of glutamatergic signalling in this region. - Source: PubMed
Publication date: 2026/06/27
Walpole Samara JLum Jeremy SChesworth RoseWalker Adam KKarl TimShannon Weickert CynthiaNewell Kelly A - Dilated cardiomyopathy (DCM) is the most common non-ischemic cardiomyopathy and a major cause of heart failure, but disease-specific molecular biomarkers remain limited. This study aimed to identify and prioritize tissue-level, disease-responsive candidate biomarkers for DCM using an integrative multi-omics bioinformatics framework. - Source: PubMed
Publication date: 2026/06/09
Li JingweiSong ZhongyangWang GuanweiChen YuchanCheng JiamiaoZhang Zhiming - This study aimed to investigate the spatial cellular architecture and molecular interactions in healthy and inflamed dental pulp using spatial transcriptomics (Visium HD), to elucidate the pathological mechanisms of pulpitis and identify potential therapeutic targets for vital pulp therapy. - Source: PubMed
Publication date: 2026/06/15
Zhang FengyuanKong YuanyuanFu XiaobinZuo JiyuanGuo QiningWang JiayiXu ManlinZeng QianZhang YuejiaoLing JunqiJiang QianzhouWei XiZheng Jianmao - Missed miscarriage is a frequent form of early pregnancy loss, yet its pathophysiology remains incompletely understood and sensitive blood-based biomarkers for detection of established missed miscarriage are limited. - Source: PubMed
Publication date: 2026/05/29
Jiang YapingSong AnnaLiu TaoNie XiaoqianWang HuiZhao LiKong QiaoqiaoLou HuanyingWang LingmeiWang HaifengZhang Bo - Preeclampsia (PE) is a pregnancy complication involving immune dysregulation. This study aims to identify diagnostic immune biomarkers for PE using machine learning. mRNA expression profiles from GSE75010 and immune-related genes from ImmPort were analyzed. Differentially expressed immune-related genes (DIRGs) were identified and subjected to GO/KEGG enrichment, PPI network, LASSO, and mSVM-RFE analyses. Candidate biomarkers were validated in additional GEO datasets (GSE54618, GSE74341, GSE147776) and by RT-PCR, Western blot, and immunohistochemistry in placental tissues. Immune cell infiltration was evaluated using CIBERSORT. Ten DIRGs were identified between PE and normotensive pregnancies. GO/KEGG analyses highlighted cytokine-cytokine receptor interactions. SERPINA3 and NDRG1 were identified as diagnostic biomarkers (AUC = 0.812 and 0.866 in training set; 0.798 and 0.781 in test set). Elevated expression of SERPINA3 and NDRG1 was confirmed in PE placental tissues. Immune analysis revealed that both genes were negatively correlated with M2 macrophages. SERPINA3 and NDRG1 are critical immune-related diagnostic biomarkers for PE and are associated with M2 macrophage reduction, providing novel insights into PE pathogenesis and diagnosis. - Source: PubMed
Publication date: 2026/06/10
Wu ZhunaChen ShihongChen WeihongXie YajingZhou ZhimeiHuang LiWang YueliChen BinbinYang CongmeiKe Yumin