SMC4 antibody (FITC)
- Known as:
- SMC4 (anti-) (fluorecein)
- Catalog number:
- orb103509
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- SMC4 antibody (FITC)
Related genes to: SMC4 antibody (FITC)
- Gene:
- SMC4 NIH gene
- Name:
- structural maintenance of chromosomes 4
- Previous symbol:
- SMC4L1
- Synonyms:
- hCAP-C, CAP-C
- Chromosome:
- 3q25.33
- Locus Type:
- gene with protein product
- Date approved:
- 2001-02-22
- Date modifiied:
- 2016-10-05
Related products to: SMC4 antibody (FITC)
Related articles to: SMC4 antibody (FITC)
- Pulmonary arterial hypertension (PAH) is characterized by aberrant vascular remodeling driven in part by excessive proliferation of pulmonary arterial smooth muscle cells (PASMCs). However, the molecular determinants underlying this cancer-like phenotype remain incompletely defined. - Source: PubMed
Publication date: 2026/06/17
Lu TingyueZhao YingZhang JiananChen HongyuBai YuxiJia JinhongChen HuitingYin JialianChen ShifanWang WentingWang HuanliangYu Xiufeng - - Source: PubMed
Publication date: 2026/06/06
Sun XuedanHe LifangLiu HongThorne Rick FrancisZeng TaofeiLiu LiuZhang BoHe MiaoHuang YabinLi MingyueGao EnyiMa MengyaoCheng ChengMeng FanzhengLang ChuandongLi HairuiXiong WanxiangPan ShixiangRen DelongDang BingyiYang YiWu MianLiu Lianxin - Accumulation of mutant mitochondrial DNA (mtDNA) heteroplasmy is among the strongest signatures of ageing. Here we investigated the underlying mechanism by calling mtDNA sequence, mtDNA abundance and mtDNA heteroplasmic variants in human blood using whole-genome sequences from approximately 750,000 individuals. We observed that mtDNA single-nucleotide variants (mtSNVs) accumulate sharply at age 60 years, occur at low levels of heteroplasmy, exhibit little evidence of positive selection and are likely to be predominantly neutral. The mutational spectrum of mtSNVs does not reflect oxidative lesions, as is commonly invoked, but is more consistent with mtDNA replication errors. To understand why mtSNVs become detectable with age, we performed a genome-wide association study for heteroplasmic mtSNV burden, identifying germline variants near TERT, TCL1A and SMC4, all of which have been linked to clonal haematopoiesis (CH). Rare-variant analysis also showed that high mtSNV burden is associated with mutations in numerous CH driver genes. These genetic associations persisted even after exclusion of individuals with known CH driver mutations. Our results support a model in which 'cryptic' mtDNA mutations initially arise randomly as replication errors but are undetectable in bulk. They then become apparent only through age-related expansion of cellular clones in blood. We propose that the high copy number and mutation rate of mtDNA make it a sensitive blood-based marker of somatic mosaicism due to CH. Our work mechanistically unifies three prominent signatures of ageing: common germline variants in TERT, CH and observed accrual of mtDNA mutations. - Source: PubMed
Publication date: 2026/05/27
Gupta RahulDurham Timothy JChau GrantKanai MasahiroUddin Md MesbahLu WenhanArgentieri M AustinKarczewski Konrad JHowrigan DanielNatarajan PradeepZhou WeiNeale Benjamin MMootha Vamsi K - E2F7 regulates cell cycle progression and is overexpressed in multiple cancers, but its role in tumor, which macrophage crosstalk in colorectal cancer (CRC) remains unclear. - Source: PubMed
Publication date: 2026/05/12
Gao ShengZuo KaiFeng LeyiCao HaileiJiao XuepingMa ChenhuiZhang QuanmaoLi Jia - Maize (Zea mays L.) is a major cereal crop of global importance, valued not only for its nutritional importance but also for its diverse phytochemical composition. Metabolomics offers a comprehensive platform to investigate physiological and biochemical alterations caused by various factors and facilitates the analysis of metabolic alterations associated with varying temperature tolerance in maize genotypes. - Source: PubMed
Publication date: 2026/04/30
Ramazan SalikaBeniwal RahulDar Zahoor AShah Manzoor A