AGPAT3 antibody
- Known as:
- AGPAT3 (anti-)
- Catalog number:
- orb39377
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- AGPAT3 antibody
Related genes to: AGPAT3 antibody
- Gene:
- AGPAT3 NIH gene
- Name:
- 1-acylglycerol-3-phosphate O-acyltransferase 3
- Previous symbol:
- -
- Synonyms:
- LPAAT-gamma, LPAAT3
- Chromosome:
- 21q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-16
- Date modifiied:
- 2019-03-26
Related products to: AGPAT3 antibody
Related articles to: AGPAT3 antibody
- Gymnema sylvestre (Retz.) R.Br. ex Sm. is a traditional herb widely used in Indian and Chinese ethnomedicine for diabetes and obesity management. Although its hypoglycemic and hypolipidemic effects have been extensively reported, a system-level understanding of how G. sylvestre modulates glucose-lipid metabolism has not been fully elucidated. - Source: PubMed
Publication date: 2026/06/20
Zeng ZhihaoLiu YanchangXiao GuanlinJia CanchaoWu MinshanLi YangxueJiang JieyiZhang JingnianXu AiliBi Xiaoli - Fatty acid (FA) composition is critical for meat quality and flavor. The regulatory role of copy number variations (CNVs) in bovine FA traits remains underexplored. Here, we integrated CNV-based genome-wide association studies (GWASs) with expression quantitative trait locus (eQTL) analysis to clarify the function of CNVs in bovine FA metabolic regulation. Using Bovine HD SNP array and RNA-seq data, we identified 21 CNVs significantly associated with 21 FA traits. Notably, a 278.6-kb duplicated CNV region (CNVR) on BTA13 was linked to the increase in docosanoic acid (C22:0) levels, and this region harbors , a gene highly expressed in the muscle, liver, and adipose tissues. Integration of SNP-GWAS and tissue-specific CNV-based eQTL data further confirmed and as key regulators of FA metabolism. Finally, cellular knockdown experiments further validated their synergistic interaction and suggested a compensatory regulatory mechanism. Our findings provide insights into CNV-mediated genetic regulation of meat quality traits in livestock. - Source: PubMed
Publication date: 2026/06/02
Liu FengWu TianyiWu JiayuanNiu QunhaoSu YingxiaoZhao ZhidaGong HuanhuanGao HuijiangLi JunyaZhu BoXu Lingyang - Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) are the primary histological subtypes of cervical cancer. Although the AGPAT family of enzymes is implicated in various cancer types, the specific roles of its members in cervical cancer remain unclear. In the present study, we investigated the value of AGPAT1-5 as potential biomarkers and therapeutic targets in cervical cancer by assessing their impact on disease development and outcomes. AGPAT gene expression data and clinical information from 306 patients with CESC and three control subjects were collected from The Cancer Genome Atlas. Given the limited number of normal cervical samples in TCGA (n = 3), we utilized the GEPIA database to integrate GTEx normal cervical samples (n = 10) as controls for differential expression analysis. These data were analyzed for differential gene expression, gene-gene and protein-protein interactions, prognostic and diagnostic value, clinical correlations, functional enrichment, and various tumor-infiltrating immune cell types. Validation was performed using two independent Gene Expression Omnibus (GEO) datasets (GSE6791 and GSE63514). The study revealed that AGPAT4 mRNA expression was significantly downregulated in cervical cancer tissues compared to normal tissues in the GEPIA analysis, while AGPAT1, AGPAT2, AGPAT3, and AGPAT5 showed no significant differences. Validation in GEO datasets demonstrated that AGPAT1, AGPAT2, and AGPAT3 were consistently downregulated in tumor tissues, whereas AGPAT5 was upregulated, and AGPAT4 showed no significant change. High levels of AGPAT3 and AGPAT4 expression, in particular, were associated with a worse prognosis in CESC patients. Immune infiltration analysis restricted to CESC samples revealed that AGPAT3 expression was significantly correlated with multiple immune cell types, including positive correlations with Macrophages M1, T cells CD4 memory resting, and Monocytes. Furthermore, guided by functional enrichment analysis implicating immune-related pathways, we examined the correlation between AGPAT3 expression and key T cell regulatory molecules, including FOXP3, IL2RA, IKZF2, and CCR8, revealing significant positive associations. In vitro assays demonstrated that knocking out AGPAT3 expression significantly decreased the proliferation and migration of HeLa and C-33 A cervical cancer cell line. These results suggest that AGPAT3 could be a valuable biomarker and a promising therapeutic target in cervical cancer. - Source: PubMed
Publication date: 2026/06/09
Gui NannanPan HanyiLu WeijuanPan GuiqiongZhou XiaoyuChen YuzhenJin MingyangYang ChangyongDong MingyouLiang Yuexiu - Nasopharyngeal carcinoma (NPC) is associated with aberrant cellular metabolism and interactions between tumor and stromal cells. This study aims to elucidate the role of glycerophospholipid metabolism in NPC, particularly focusing on the interplay between malignant epithelial cells and fibroblasts. - Source: PubMed
Publication date: 2026/05/20
Wang LipingWang DujuanLi ShuangLiu GuohongLi YirongPan Yunbao - Clutch persistence, defined as the ability to sustain consecutive egg-laying cycles, is a pivotal determinant of profitability in the poultry industry, particularly for aging laying hens (≥65 weeks). However, the molecular mechanisms governing this trait remain elusive, largely due to the traditional "ovary-centric" paradigm that overlooks systemic regulation by the gut microbiota. To address this knowledge gap, the present study aimed to dissect the comprehensive regulatory network governing clutch persistence using integrated multi-omics analyses. A total of 20 sixty-five-week-old Rhode Island Red (RIR) laying hens with cumulative egg production exceeding 300 eggs but distinct clutch persistence were stratified into a high-clutch persistence group (HCP, ≥25 clutches, = 10) and a low-clutch persistence group (LCPLCP, ≤15 clutches, = 10). Multi-omics profiling, including ovarian transcriptomics, proteomics, and metabolomics; serum metabolomics; and cecal microbiota 16S rRNA sequencing was performed. Data integration and association mining were conducted via Spearman correlation analysis with stringent thresholds (r > 0.6, < 0.01). Integrated analyses revealed a "gut-ovary axis" regulatory model mediated by a lipid mediator network, operating through a three-tiered mechanism: (1) Gut Initiation: The HCP group exhibited enriched cecal γ-Proteobacteria, which promoted biosynthesis of lipid precursors. (2) Serum Transport: Key serum lipid mediators, most notably LysoPC (22:6) (VIP = 4.5) and cholesterol ester CE (20:4), served as critical carriers transducing gut-derived signals to the ovary. (3) Ovarian Execution: These lipid signals activated a core ovarian metabolic pathway centered on the PLA2G6-ALOX15B-AGPAT3 axis, which coordinated follicular development and ovulation by supplying steroid hormone synthesis substrates, exerting anti-inflammatory effects, and stabilizing membrane structures. Collectively, this study demonstrates that gut microbiota modulates clutch persistence in aging laying hens via lipid mediators, orchestrating a systemic "gut-serum-ovary" regulatory cascade. These findings provide a novel molecular framework for extending the economic egg-laying cycle through the targeted manipulation of intestinal microbiota or serum lipid metabolism. - Source: PubMed
Publication date: 2026/05/11
Li XinWang XiaoliangCai XiaMeng QiangSun YanyanYang ChangsuoYao Junfeng