GNAO1 antibody
- Known as:
- GNAO1 (anti-)
- Catalog number:
- orb39825
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- GNAO1 antibody
Related genes to: GNAO1 antibody
- Gene:
- GNAO1 NIH gene
- Name:
- G protein subunit alpha o1
- Previous symbol:
- -
- Synonyms:
- G-ALPHA-o
- Chromosome:
- 16q13
- Locus Type:
- gene with protein product
- Date approved:
- 1988-04-24
- Date modifiied:
- 2016-03-03
Related products to: GNAO1 antibody
Related articles to: GNAO1 antibody
- This study investigated the effect of single Gα and Gα, as well as double Gα knockout on the cerebellar anatomy and synapse formation. The alpha subunit of the G protein Go exists in two splice variants. Knockout of certain Gαo subtypes result in strong-mainly motor-deficits in mice, and mutations in the responsible gene locus in humans can result in severe encephalopathies. We aimed to decipher the hitherto incompletely understood contribution of the individual Gα subunits to the anatomy and synapse formation of the cerebellum. Knockout of Gα reduced the size of the cerebellum by 11%, accompanied by maximal reductions of the molecular layer thickness in the central lobule III (-30%) and molecular layer area in the uvula (-33%). Knockout of Gα increased cerebellar size, molecular layer thickness in central lobule II (+18.6%), and area of the culmen (+37%). Combined deletion of Gα and Gα reduced cerebellar size by 12%, molecular layer thickness and area of the declive (by -27.3% and -23.4%, respectively). Moreover, VGLUT2-positive climbing fiber contacts to Purkinje cells were reduced in Gα knockout mice (on average by 40%). Similarly, VGLUT1 expression was reduced (on average by 17.3%). The knockout of Gα promoted climbing fiber contacts (+14.3% on average, at a maximum of +52.6% in the central lobule II), VGLUT1 was less affected. Double knockout mice exhibited negative effects on VGLUT2 (-35% overall number) and VGLUT1 (-23% on average in expression levels). VGAT-positive synaptic contacts were also diminished for Gα and double knockout (-25% and -31% overall number, respectively) and increased for Gα knockout (+13% on average). In line with this, negative effects on the dendritic outgrowth of Purkinje cells were observed in both Gα and Gα mice, while knockout of Gα promoted dendrite outgrowth. Taken together, the two Gαo splice variants contrarily contribute to the development of the cerebellum, with Gα representing the dominant subunit. - Source: PubMed
Höltje MarkusWolkowicz AntonAhnert-Hilger Gudrun - Neuropathic pain is a debilitating condition with limited effective treatments, highlighting an urgent need for non-opioid analgesic targets. Gαo, encoded by the Gnao1 gene, is an abundant G protein in the nervous system and couples to multiple inhibitory GPCRs, but its role in chronic pain remains poorly understood. - Source: PubMed
Publication date: 2026/06/23
Cai JieyiLi HuiChen LüLuo LingWu XinYuan MinHan MaolinWen ShirongZhu ChanglaiGu Yun - Epilepsy is a heterogeneous neurological disorder characterized by recurrent, unprovoked seizures, with genetic factors playing a major role in its etiology, particularly in consanguineous populations where recessive variants are more prominent. - Source: PubMed
Publication date: 2026/06/18
Ali QaisarAzam SadiqJaved JamilaZaheer MuhammadUllah SaqibIqbal AqibKhan IbrarRehman Shoaib Ur - Childhood-onset dystonia (COD) encompasses a clinically and etiologically heterogeneous group of disorders, often with overlapping features. Genetic testing plays a pivotal role in uncovering underlying causes, identifying treatable subtypes, and informing individualized management strategies. - Source: PubMed
Publication date: 2026/06/16
Yilmaz SanemSerdaroglu EsraSimsek ErdemKara BulentTurkdogan DilsadYis UlucErol IlknurYuksel DenizKanmaz SedaEroglu ArzuCanpolat MehmetKomur MustafaCıtak Kurt NeseSakarya Gunes AyferSoydemir DidemBesen SeydaBektas OmerKirik SerkanAtalay Celik HaleArdicli DidemAksoy AyseYarar CoskunCerci Kubur CisilOlgac Dundar NihalGungor OlcayKamasak TulayOlculu Cemile BusraGumus HakanYildirim MiracIsik EsraAtik TahirCogulu OzgurBasak Ayse NazliSunnetci Akkoyunlu DenizÖzbakır Derya HazalKayhan GülsümGerik Çelebi Hamide BetulKaraer KadriDundar MunisKaiyrzhanov RauanCeylaner SerdarPer HuseyinHiz Ayse SemraCansu AliOkuyaz CetinAnlar BanuTekgul Hasan - GNAO1-related disorder (GNAO1-RD) is ultra-rare and clinically heterogeneous. Often, children with GNAO1-RD have (severe) motor impairments, which may lead to an underestimation of their communication abilities. To help these children achieve their full potential in daily life, it is essential to understand their communicative abilities and limitations. In this study, we aimed to investigate spoken language comprehension (SLC), speech and functional communication. - Source: PubMed
Publication date: 2026/06/05
Heideman Larissa RGeytenbeek JohannaWolf Nicole IBuizer Annemieke Ivan de Pol Laura A