prox1 antibody (FITC)
- Known as:
- prox1 (anti-) (fluorecein)
- Catalog number:
- orb9651
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- Biorb
- Gene target:
- prox1 antibody (FITC)
Related genes to: prox1 antibody (FITC)
- Gene:
- PROX1 NIH gene
- Name:
- prospero homeobox 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1q32.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-05-18
- Date modifiied:
- 2016-10-05
Related products to: prox1 antibody (FITC)
Related articles to: prox1 antibody (FITC)
- Pulmonary arterial hypertension (PAH) is characterized by excessive remodeling of the proximal and distal arterioles, driven by endothelial cell apoptosis and uncontrolled mural cell proliferation. Increasing evidence suggests an important role of inflammation in PAH, but 1 crucial part of the immune system, the pulmonary lymphatics, has been largely overlooked. Patients with idiopathic PAH often develop abnormal tertiary lymphoid structures adjacent to remodeled arteries, yet the role of lymphatic vessels in PAH pathogenesis and vascular remodeling remains unclear. Using a mouse model to specifically label lymphatic endothelial cells (Prox1-CreERT2::Rosa26-LSL-tdT), we found that pulmonary lymphatic vessels proliferated and dilated in response to hypoxia. We further showed that Vegfr3 inhibition using MAZ51 reduced hypoxia induced lymphangiogenesis and was associated with severe pulmonary hypertension. Additionally, lymphatic endothelial cell-specific deletion of Vegfr3 (Prox1-CreERT2::Vegfr3) prevents adaptive lymphangiogenesis and exacerbates pulmonary hypertension, resulting in right ventricular hypertrophy. Comparative single-cell RNA sequencing analysis of human idiopathic PAH and hypoxia-induced pulmonary hypertension mouse lungs revealed upregulation of in lymphatic endothelial cell clusters, and in humans this was associated with enhanced expression of FLT4/VEGFR3 and downstream mediators in the MEK/ERK signaling pathway. Consistently, increased CD74 expression was observed in lymphatic vessels in human idiopathic PAH lung sections, and CD74 overexpression in human lymphatic cells was associated with impaired barrier permeability and coexpression of VEGFR3. Together, these findings provide novel insights into the role of lymphatic Cd74/CD74 activation in pulmonary hypertension development and suggest that therapies aimed at augmenting lymphatic function may improve outcomes in patients with PAH. - Source: PubMed
Publication date: 2026/06/03
Moss M ElizabethKlouda TimothyLi YanLiu YuTan MengKim YunhyeHao YuanTian WenNicolls Mark RWu Joseph CBucala RichardChen HongLee EungjooTran-Lundmark KarinRaby BenjaminYuan Ke - The "metabolism-inflammation" vicious cycle is an important driving factor for lymphatic dysfunction in secondary lymphedema (SL). Among them, lymph endothelial cells (LECs) act as a key regulatory hub. Liubao tea (LBT), a traditional post-fermented black tea, has anti-inflammatory, anti-fibrotic and lipid-lowering effects. However, whether the effects of LBT can extend to the lymphatic system, especially whether it functions by regulating the metabolism and immune function of LECs, still needs further clarification. - Source: PubMed
Publication date: 2026/05/18
Huang XiaoxiaoTan ZhibiaoLu ChuanXu Jianwen - The omentum is a vascularized, immune-active tissue with regenerative potential, particularly when activated by intraperitoneal stimuli. Its secreted factors may promote lymphangiogenesis, offering a novel approach to lymphedema treatment. - Source: PubMed
Publication date: 2026/05/29
Hojo MasahiroSeo DongkyungIto RiriIshikawa KosukeMiura TakahiroFunayama EmiYamamoto YuheiMaeda Taku - This study aims to analyze the dynamic changes in lymphatic endothelial cell (LEC) markers during the progression of intervertebral disk degeneration (IDD) and to investigate their association with the progression of IDD. In this study, intervertebral disk (IVD) specimens were first collected from patients who underwent open lumbar fusion surgery for spinal fractures (control group, = 10) and lumbar disk herniation (IDD group, = 10). Concurrently, a mouse IDD model was established, and IVD specimens were collected from mouse in the Sham group and the IDD group 1, 3, and 6 weeks after modeling ( = 5 per group at each time point). Pathological morphological changes in human and mouse IVD specimens were observed using Hematoxylin and Eosin (H&E) and Masson's Trichrome staining. The degree of degeneration in the mouse IVD specimens was quantified using a histopathological scoring system. Subsequently, real-time quantitative polymerase chain reaction (RT-qPCR), immunohistochemistry (IHC), and immunofluorescence (IF) staining were employed to examine LEC markers in IVD tissue, including lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), podoplanin (PDPN), prospero homeobox protein 1 (PROX-1), and vascular endothelial growth factor receptor 3 (VEGFR-3), as well as matrix metabolism-related markers such as matrix metalloproteinase 13 (MMP-13) and collagen II (Col II). Finally, we performed Spearman's rank correlation analysis between the histopathological scores of all mouse IVD specimens and the corresponding expression levels of LEC markers. In human IVD tissue, expression levels of LYVE-1, PDPN, PROX-1, and VEGFR-3 were extremely low in the normal group. In contrast, expression of these markers was significantly upregulated in the IDD group. In the mouse IDD model, compared with the Sham group at the same time point, the IDD group exhibited higher histopathological scores in IVD tissue, accompanied by upregulation of LYVE-1, PDPN, PROX-1, and MMP-13, as well as downregulation of Col II. In-depth analysis revealed that these differences between the Sham and IDD groups were not static but exhibited a dynamic pattern of increasing magnitude over time. Concurrently, as the modeling period progressed, the histopathological scores of mouse IVD in the IDD group, as well as the expression levels of LYVE-1, PDPN, PROX-1, and MMP-13, showed a progressive upward trend, while Col II expression progressively decreased. In addition, Spearman's rank correlation analysis revealed that the expression levels of LYVE-1, PDPN, and PROX-1 in mouse IVD tissue were all significantly positively correlated with histopathological scores. In the process of IDD, the dynamic upregulation of LEC markers is highly consistent with its severity in the time dimension. At the same time, there was also a significant positive correlation between the expression level of LEC markers and the severity of IDD. Taken together, these findings suggest that the dynamic upregulation of LEC markers may be potentially associated with the pathological progression of IDD. - Source: PubMed
Publication date: 2026/04/27
Zhang QiangLin MaoqiangYan ShishunHuang FeiZhou Haiyu - Psoriasis, a persistent inflammatory skin ailment, is distinguished by aberrant γδT17 cell activation. The primary active compound in Bergenia purpurascens, bergenin (Ber), a natural peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, appears to exhibit anti-γδT17 cell activation effects; nevertheless, its therapeutic efficacy for psoriasis remains to be elucidated. - Source: PubMed
Publication date: 2026/05/13
Lin HaochangGuo YileiWan XuanmingHe YueZhu YanrongWei ZhifengXia YufengDai Yue