Rat Anti Mouse LY6G Biotin
- Known as:
- Rat Anti Mouse LY6G Biotin
- Catalog number:
- ant-074
- Product Quantity:
- 05mg
- Category:
- -
- Supplier:
- Prospecbio
- Gene target:
- Rat Anti Mouse LY6G Biotin
Related genes to: Rat Anti Mouse LY6G Biotin
- Gene:
- LY6G6F NIH gene
- Name:
- lymphocyte antigen 6 family member G6F
- Previous symbol:
- LY6G6D, C6orf21
- Synonyms:
- G6f, NG32
- Chromosome:
- 6p21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-05
- Date modifiied:
- 2017-01-27
Related products to: Rat Anti Mouse LY6G Biotin
Related articles to: Rat Anti Mouse LY6G Biotin
- Considering that there are no effective biomarkers for the screening of cardia gastric cancer (CGC), we developed a noninvasive diagnostic approach, employing data-independent acquisition (DIA) proteomics to identify candidate protein markers. - Source: PubMed
Publication date: 2023/10/19
Gu JianhuaXie ShuanghuaLi XinqingWu ZemingXue LiyanWang ShaomingWei Wenqiang - Respiratory syncytial virus (RSV) is one of the important pathogenic agents of pediatric respiratory tract infection. Weighted gene co-expression network analysis (WGCNA) is used to study autoimmune diseases, which can find potential hub genes. The diagnostic model based on hub genes and machine learning makes it possible to diagnose the extracellular immune response to RSV infection early. - Source: PubMed
Publication date: 2022/08/28
Wang BaohongLiu Hongbo - is a Gram-positive, intracellular pathogen that causes Bacterial Kidney Disease (BKD) in several fish species in freshwater and seawater. Lumpfish () is utilized as a cleaner fish to biocontrol sea lice infestation in Atlantic salmon () farms. Atlantic salmon is susceptible to , and it can transfer the infection to other fish species. Although BKD outbreaks have not been reported in lumpfish, its susceptibility and immune response to is unknown. In this study, we evaluated the susceptibility and immune response of lumpfish to infection. Groups of lumpfish were intraperitoneally (i.p.) injected with either (1×10, 1×10, or 1×10 cells dose) or PBS (control). infection kinetics and mortality were followed for 98 days post-infection (dpi). Transcript expression levels of 33 immune-relevant genes were measured in head kidney ( = 6) of fish infected with 1×10 cells/dose and compared to the control at 28 and 98 dpi. Infected lumpfish displayed characteristic clinical signs of BKD. Lumpfish infected with high, medium, and low doses had a survival rate of 65%, 93%, and 95%, respectively. Mortality in the high-dose infected group stabilized after 50 dpi, but persisted in the fish tissues until 98 dpi. Cytokines (, , ), pattern recognition receptors (), interferon-induced effectors (, , ), and iron regulation () and acute phase reactant () related genes were up-regulated at 28 dpi. In contrast, cell-mediated adaptive immunity-related genes (, , , , ) were down-regulated at 28 dpi, revealing the immune suppressive nature of . However, significant upregulation of at 98 dpi suggests induction of cell-mediated immune response. This study showed that infected lumpfish in a similar fashion to salmonid fish species and caused a chronic infection, enhancing cell-mediated adaptive immune response. - Source: PubMed
Publication date: 2021/11/22
Gnanagobal HajaroobaCao TrungHossain AhmedDang MyHall Jennifer RKumar SurendraVan Cuong DoanBoyce DannySantander Javier - Mutations within Granulin (GRN) gene are causative of autosomal dominant frontotemporal lobar degeneration (FTLD). Though GRN mutations are inherited at birth, the disease onset usually occurs in the sixth decade of life. The objective of this study was to identify new genetic pathways linked to inherited GRN disease and involved in the shift from asymptomatic to symptomatic stages. Microarray gene expression analysis on leukocytes was carried out on 15 patients carrying GRN T272SfsX10 mutation, and their asymptomatic siblings with (n = 14) or without (n = 11) GRN mutation. The results were then validated by real-time polymerase chain reaction, and compared with those obtained in a cohort of FTLD without GRN mutation (n = 16). The association between candidate genes and damage of specific brain areas was investigated by voxel-based morphometry on magnetic resonance imaging scans (family-wise error-corrected). Leukocytes mRNA levels of TMEM40 and LY6G6F and other genes mainly involved in inflammation were significantly higher in patients carrying GRN mutations compared with asymptomatic carriers and other FTLD. The higher the levels of TMEM40 the greater is the damage of parietal lobule; the higher the LY6G6F gene expression the greater is the atrophy in superior frontal gyrus. Enhanced inflammation associated with the onset of GRN disease might be either related to disease pathogenetic mechanism leading to neurodegeneration or to a compensatory pathway that counteracts disease progression. The identification of specific molecular targets of GRN-FTLD disease is essential when considering future disease-modifying therapies. - Source: PubMed
Publication date: 2013/02/15
Milanesi ElenaBonvicini CristianAlberici AntonellaPilotto AndreaCattane NadiaPremi EnricoGazzina StefanoArchetti SilvanaGasparotti RobertoCancelli VanessaGennarelli MassimoPadovani AlessandroBorroni Barbara - In teleost fish, a novel gene G6F-like was identified, encoding a type I transmembrane molecule with four extracellular Ig-like domains and a cytoplasmic tail with putative tyrosine phosphorylation motifs including YxN and an immunoreceptor tyrosine-based activation motif (ITAM). G6F-like maps to a teleost genomic region where stretches corresponding to human chromosomes 6p (with the MHC), 12p (with CD4 and LAG-3), and 19q are tightly linked. This genomic organization resembles the ancestral "Ur-MHC" proposed for the jawed vertebrate ancestor. The deduced G6F-like molecule shows sequence similarity with members of the CD4/LAG-3 family and with the human major histocompatibility complex-encoded thrombocyte marker G6F. Despite some differences in molecular organization, teleost G6F-like and tetrapod G6F seem orthologous as they map to similar genomic location, share typical motifs in transmembrane and cytoplasmic regions, and are both expressed by thrombocytes/platelets. In the crucian carps goldfish (Carassius auratus auratus) and ginbuna (Carassius auratus langsdorfii), G6F-like was found expressed not only by thrombocytes but also by erythrocytes, supporting that erythroid and thromboid cells in teleost fish form a hematopoietic lineage like they do in mammals. The ITAM-bearing of G6F-like suggests that the molecule plays an important role in cell activation, and G6F-like expression by erythrocytes suggests that these cells have functional overlap potential with thrombocytes. - Source: PubMed
Publication date: 2010/07/08
Ohashi KenTakizawa FumioTokumaru NorihiroNakayasu ChihayaToda HideakiFischer UweMoritomo TadaakiHashimoto KeiichiroNakanishi TeruyukiDijkstra Johannes Martinus