DISC POLYETH 20MU PKG 100
- Known as:
- DISC POLYETH 20MU PKG 100
- Catalog number:
- 28400-20002
- Product Quantity:
- Case of 100
- Category:
- -
- Supplier:
- COREX
- Gene target:
- DISC POLYETH 20MU PKG 100
Related genes to: DISC POLYETH 20MU PKG 100
- Gene:
- DISC2 NIH gene
- Name:
- disrupted in schizophrenia 2
- Previous symbol:
- -
- Synonyms:
- DISC1-AS1, DISC1OS, NCRNA00015
- Chromosome:
- 1q42.1
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2000-01-20
- Date modifiied:
- 2018-05-16
Related products to: DISC POLYETH 20MU PKG 100
Related articles to: DISC POLYETH 20MU PKG 100
- Traumatic brain injury (TBI) triggers complex molecular and cellular responses that persist well beyond the initial injury. Neuroinflammation is a prominent feature of the post-injury response and a significant contributor to progressive neuronal dysfunction and increased risk of chronic neurodegeneration. Epigenetic mechanisms have emerged as important regulators of the injury response. Astrocytes are increasingly recognized as key mediators of this epigenetic regulation. Injury-induced epigenetic reprogramming in astrocytes may perpetuate maladaptive inflammatory and metabolic states, thereby increasing vulnerability to delayed neurodegeneration. Preclinical studies suggest that pharmacologic or genetic modulation of epigenetic regulators can improve outcomes after experimental TBI. However, clinical translation remains constrained by limited cell-type specificity and potential off-target effects. This review evaluates current evidence on epigenetic regulation after TBI, with an emphasis on astrocyte-centered mechanisms linking acute injury to chronic pathology. We further discuss key translational challenges and highlight emerging precision strategies aimed at cell-type-specific, temporally controlled epigenetic modulation to mitigate long-term neurological consequences. - Source: PubMed
Publication date: 2026/07/22
Li LulinBonfoey Alyssa MSun BryanHarris Odette ALuo Jian - Human induced pluripotent stem cells (hiPSCs) are powerful tools for disease modeling and therapeutic development, though their utility remains sensitive to operator-dependent variability and media formulation. Commercial stem cell media formulations, such as mTeSR+ and StemFlex, are designed to support robust pluripotent stem cell maintenance and improve reproducibility. While both are widely used, direct comparisons are limited. We evaluated mTeSR+ and StemFlex using the CellXpress.ai automated tissue culture platform in combination with IN Carta machine-learning-based image analysis to monitor and standardize feeding, passaging, and maintenance. Wild-type iP11N hiPSCs were cultured under standardized automated conditions with growth kinetics, immunocytochemical marker expression, and RT-qPCR assessment. Automated analysis revealed no significant differences in proliferation rates between the formulations; however, longitudinal image-based quantification identified statistically significant differences (<1%) in differentiated cell area fraction across the imaging period. Immunocytochemistry demonstrated comparable expression and localization of pluripotency-associated markers, and RT-qPCR analysis confirmed similar expression of stemness factors. These findings demonstrate that both media support comparable growth and maintenance of pluripotency under standardized automated conditions on iP11N wild-type stem cells in the short-term culture conditions analyzed. Additionally, these data highlight the value of automated imaging and machine-learning-based analysis in reducing operator-dependent variability and improving consistency in hiPSC culture, supporting its application in high-throughput stem cell research. - Source: PubMed
Publication date: 2026/08/25
Bogoniewski Aleksander AGonzalez Melissa FReyes Rachel ERivera Susanna FTaylor CameronSchurr ToddDamoiseaux RobertLipshutz Gerald S - Lipid nanoparticles (LNPs) have great potential as nucleic acid delivery vehicles; however, they trigger the production of inflammatory cytokines, which limits their medical applications. Developing non-inflammatory LNPs is challenging because the LNP's ionizable lipid and the process of endosomal disruption are the major sources of LNP toxicity but are also essential for delivering nucleic acids. Here we demonstrate that ionizable lipids containing a carboxylic acid and an amine (termed S-lipid) switch their charged state between the pHs of 7.4 and 4.0, allowing them to generate LNPs (termed switchable nanoparticles) that efficiently encapsulate nucleic acid and trigger endosomal release without activation of the TLR4, complement, galectin-8 and platelet activating factor signalling pathways. Finally, we demonstrate that switchable nanoparticles are better at treating lipopolysaccharide-induced acute lung injury than traditional LNPs because they do not exacerbate pre-existing inflammation. Collectively, these results demonstrate that negatively charged ionizable lipids can mitigate the toxicity of LNPs. - Source: PubMed
Publication date: 2026/09/08
Liang DengpanQi YalinHan HesongAhmadian NegarGao KewaSapasap KayceeZhang YuxiGuo SilinLawanprasert AtipPimcharoen SopidaZhao ShengDel Buono Milan TXia HeEnders Zoe OBurgstone Benjamin WCalio AntoninoDankar NeelLu BingweiQi Lei SWang AijunMurthy Niren - Radiation therapy is a standard-of-care oncological treatment for central nervous system (CNS) malignancies. However, as survival outcomes improve, radiation-induced injury to normal brain tissue has increased in clinical significance. CNS radiation injury is a delayed, multifactorial process characterized by impaired neurogenesis, reactive gliosis, and persistent functional deficits. Mechanistic exploration and development of effective radiation mitigators have been limited by the lack of scalable, human-relevant models. - Source: PubMed
He LingKornblum Harley IBhaduri AparnaPajonk Frank - V2a interneurons are excitatory neurons found throughout the hindbrain and spinal cord, two regions that arise from distinct progenitors during embryonic development. Whether this lineage difference shapes mature gene regulation and function is unknown. V2a neurons show plasticity after spinal cord injury and are candidates for cell therapy. We differentiated human stem cells into V2a neurons through hindbrain- and spinal cord-like progenitor routes and profiled them by single nucleus multiomic sequencing. The two lineages showed distinct transcription factor motif enrichment and differentially expressed genes governing axon growth and calcium handling. Inducing V2a transcription factors directly, bypassing developmental patterning, produced a population unlike either lineage, confirming progenitor history is not interchangeable. Using CellOracle and lentiviral knockdown, we identified CREB5 and TCF7L2 as regulators specific to the spinal-like lineage. These results show that progenitor origin shapes V2a identity and reveal new regulators of neural diversity along the anterior-posterior axis. - Source: PubMed
Publication date: 2026/07/29
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