CLOSURE,PPL,S T,WHITE
- Known as:
- CLOSURE,PPL,S T,WHITE
- Catalog number:
- 20024-250
- Product Quantity:
- Case of 144
- Category:
- -
- Supplier:
- COREX
- Gene target:
- CLOSURE PPL WHITE
Related genes to: CLOSURE,PPL,S T,WHITE
- Gene:
- ABCG4 NIH gene
- Name:
- ATP binding cassette subfamily G member 4
- Previous symbol:
- -
- Synonyms:
- WHITE2
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-16
- Date modifiied:
- 2016-10-05
Related products to: CLOSURE,PPL,S T,WHITE
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- Gastric cancer (GC) remains a major cause of cancer-related mortality worldwide. Increasing evidence suggests that metabolic reprogramming contributes to GC progression, yet the prognostic significance of uric acid metabolism-related genes in GC remains unclear. This study aimed to characterize uric acid metabolism-related genes with prognostic and pharmacological relevance in gastric cancer and to explore their potential value for risk stratification and drug-response prediction. Differentially expressed genes between tumor and normal tissues were obtained from public databases and intersected with uric acid metabolism-related genes to identify candidate genes. Prognostic genes were screened using univariate Cox regression and machine learning algorithms, and a prognostic risk model was subsequently established. Patients were classified into high- and low-risk groups based on the risk score. Functional enrichment, somatic mutation, drug sensitivity, and single-cell transcriptomic analyses were further performed. RT-qPCR was used to validate gene expression in gastric cancer cell lines. A total of 657 candidate genes were identified from the intersection of 4514 differentially expressed genes and 3806 uric acid metabolism-related genes. Three genes, ABCG4, SERPINE1, and GPX3, were selected to construct the prognostic model. Patients in the high-risk group had significantly worse survival than those in the low-risk group. Multivariate Cox analysis showed that both risk score and age were independent prognostic factors for GC. Enrichment analysis indicated that pentose and glucuronate interconversions were significantly associated with the high-risk group. Drug sensitivity prediction showed lower predicted half-maximal inhibitory concentration (IC50) values for selected agents, including AZD8055, in the high-risk subgroup, suggesting a potential association with pharmacogenomic drug-response patterns. Single-cell analysis highlighted fibroblasts as a key cell population. RT-qPCR confirmed downregulation of ABCG4 and GPX3 and upregulation of SERPINE1 in GC cell lines. These findings identified prognostic features associated with uric acid metabolism in gastric cancer and suggest that ABCG4, SERPINE1, and GPX3 may be involved in metabolic dysregulation, matrix remodeling, and predicted pharmacogenomics response patterns. - Source: PubMed
Publication date: 2026/06/27
Wu WenhanWei Zhengqiang - Pulmonary alveolar proteinosis (PAP) is a rare lung disease with primary (usually autoimmune) and secondary forms. Unlike the autoimmune type, which can be treated with cytokine therapy or whole-lung lavage, the secondary form associated with occupational particulate exposure, such as indium compounds, has no established therapy and remains challenging to treat. - Source: PubMed
Publication date: 2026/06/07
Jeon SoyeonKim GyuriCho Wan-Seob - Alloantigen H is one of thirteen systems in the chicken. Little is known about this system which has two serological alleles. The objectives of this study were (1) to identify the genetic region encoding the chicken alloantigen H, and (2) to develop DNA detection-based methods to aid H system allele identification. - Source: PubMed
Publication date: 2026/03/31
Fulton Janet EMcCarron Amy MWolc AnnaSparling Brandi AAli LowdanJaeger CourtneyTaylor Robert L - Docetaxel (DTX) is a standard chemotherapy agent for castration-resistant prostate cancer (CRPC); however, DTX resistance remains a major clinical challenge, and the underlying molecular mechanisms are not fully understood. In our study, it was found that OTUB2 was highly expressed in DTX-resistant CRPC and could be served as a key driver of DTX resistance. Mechanistically, OTUB2 stabilizes the m5C reader ALYREF by removing its K48-linked polyubiquitin chains, leading to increased ALYREF protein levels. And then, ALYREF enhances the mRNA stability and expression of ABCG4, thereby promoting ATP-dependent efflux of DTX. Moreover, the expression of OTUB2 mRNA and protein could be regulated by FOXD3-AS1 derived from cancer-associated fibroblasts (CAFs). More importantly, treatment with OTUB2 inhibitor (OTUB2-IN-1) resensitized resistant CRPC to DTX. Together, our findings establish OTUB2 as a novel driver of DTX resistance in CRPC and highlight the role of CAFs-derived FOXD3-AS1 and OTUB2/ALYREF/ABCG4 axis in modulating DTX resistance of CRPC. - Source: PubMed
Publication date: 2026/03/17
Ke Zhi-BinChen Jia-YinLin BinChen Chao-RanXue Yu-TingSun Jiang-BoYan Zi-HengZhao Yu-XuanLiu Meng-XinWang ZhenXue Xue-YiZheng Qing-ShuiWei YongXu Ning - Essential tremor (ET) is the most common adult-onset movement disorder, yet its genetic basis remains incompletely understood. Although familial aggregation is well recognized, ET shows marked genetic heterogeneity, with many rare and family-specific variants reported. - Source: PubMed
Publication date: 2026/02/25
Aghayev AgharzaErdoğdu MeldaAydemir DuyguBagirova GulendamAslanger Ayca DilrubaCankay Tugba UyarAkcakaya Nihan HandeUyguner Zehra Oya