STAT6 Antibody (Phospho-Tyr641), pAb, Rabbit
- Known as:
- STAT6 Antibody (Phospho-Tyr641), pAb, Rabbit
- Catalog number:
- A00263-100
- Product Quantity:
- 100,0μg
- Category:
- -
- Supplier:
- Genscript
- Gene target:
- STAT6 Antibody (Phospho-Tyr641) pAb Rabbit
Related genes to: STAT6 Antibody (Phospho-Tyr641), pAb, Rabbit
- Gene:
- STAT6 NIH gene
- Name:
- signal transducer and activator of transcription 6
- Previous symbol:
- -
- Synonyms:
- D12S1644, IL-4-STAT
- Chromosome:
- 12q13
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-09
- Date modifiied:
- 2019-04-23
Related products to: STAT6 Antibody (Phospho-Tyr641), pAb, Rabbit
Related articles to: STAT6 Antibody (Phospho-Tyr641), pAb, Rabbit
- Cerebral small-vessel disease (CSVD) represents a major etiology of vascular cognitive impairment (VCI), driven by pathological processes such as cellular senescence and neuroinflammation. Among these, microglia-the brain's specialized immune cells-play a key role in driving neuroinflammation through their senescence, thereby exacerbating cognitive dysfunction. Although signal transducer and activator of transcription 6 (STAT6) activation has been implicated in alleviating neuroinflammation and cognitive deficits in CSVD, the underlying mechanisms remain unclear. This study sought to elucidate the roles of STAT6 and autophagy in the process of microglial senescence induced by CSVD. Using stroke-prone renovascular hypertensive rats (RHRSP) and chronic hypoxia-treated BV2 cells to assess cognitive function, microglial senescence, and autophagy, we observed that phosphorylation-mediated STAT6 activation significantly suppressed microglial senescence. Mechanistically, we found that phosphorylated STAT6 (pSTAT6) enhanced autophagy, which reduced the burden of senescent microglia and thereby ameliorated CSVD-induced VCI. These findings provide insights into the potential of targeting the STAT6 pathway in VCI associated with CSVD. - Source: PubMed
Publication date: 2026/07/17
Liu XiaoluLiu QingYang JingwenHu XiaZhu XiaoqiuZhang ZhanZuo YouHuang JialinWu LeleFan YuhuaTang YameiShi Zhongshan - Glomangiopericytoma (GPC) is a rare sinonasal mesenchymal neoplasm with distinctive morphologic and molecular features, most commonly arising in the nasal cavity and paranasal sinuses. Occurrence in the nasopharynx is exceptionally uncommon and may create a substantial diagnostic challenge, particularly in long-term survivors of nasopharyngeal carcinoma (NPC) after radiotherapy, in whom a newly detected nasopharyngeal mass is often clinically presumed to represent recurrent carcinoma.In this setting, diagnosis should rest on the combined assessment of growth architecture, cytologic blandness, and a targeted exclusionary immunohistochemical panel rather than on clinical history, imaging appearance, or any single marker alone. - Source: PubMed
Publication date: 2026/07/17
Wu JinzhiShen ShashaWu MingnaFeng GuangyongGou Xiaoxia - Human THP-1 monocyte-like cells are a commonly used model for monocyte-derived macrophages (MoDM) in vitro, and significant literature has demonstrated how MoDM phenotype depends on the type, concentration, and duration of differentiation stimuli. However, far less attention has been given to how the choice of differentiation protocols actively reprograms transcriptional signaling networks during the differentiation process. Monocytes begin transcriptional and signaling rewiring immediately upon exposure to differentiation cues, suggesting that these early events condition how macrophages later respond to inflammatory and polarizing stimuli. As a result, differentiation protocols should be considered not as equally neutral preparatory steps, but as biologically active variables that modulate downstream signaling behavior. We compared three differentiation stimuli: PMA, GM-CSF, and M-CSF, to investigate how each agent influenced the temporal activity of key transcription factors. We generated THP-1 cells expressing bioluminescent reporters for CMV, NF-κB and STAT6, enabling longitudinal, quantitative assessment of transcription factor activity throughout differentiation. We found that PMA and GM-CSF enhanced NF-κB activation, whereas M-CSF led to higher STAT6 activity. We also observed that PMA induced early spikes in NF-κB activity and GM-CSF delayed NF-κB activation at later differentiation stages, revealing distinct temporal signaling programs. Differentiation stimuli also induced early-stage downregulation of CMV promoter activity, underscoring global transcriptional remodeling during macrophage maturation. Cytokine assays following secondary polarization demonstrated that CSF-differentiated macrophages exhibited greater responsiveness and dynamic range compared with PMA-differentiated cells. Together, these findings demonstrate that THP-1 differentiation protocols encode stimulus- and time-dependent transcriptional states that directly impact macrophage function. This study establishes temporal transcription factor profiling as a powerful framework for selecting differentiation strategies and experimental timepoints, improving biological relevance and reproducibility in in vitro macrophage models. - Source: PubMed
Publication date: 2026/07/13
James ZacharyLi ColetteSpassennikova AnnaZheng ShiyuanBrown ChloeAnand MeghaChiang Yi-HsuanWayne Elizabeth - Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm with a low incidence, and pelvic SFT is extremely uncommon. Due to its insidious onset and nonspecific imaging features, preoperative diagnosis is difficult. We reported a 34-year-old male patient with a giant pelvic SFT found incidentally during physical examination, complicated with left hydronephrosis and hydroureter. Preoperative imaging revealed a large heterogeneous enhanced mass in the pelvic cavity. Robot-assisted laparoscopic resection of the tumor was performed successfully, accompanied by simultaneous ureteral reimplantation due to severe adhesion between the tumor and the left ureter. The operation was completed with R0 resection. Postoperative pathology and immunohistochemistry (STAT6+, CD34+, Bcl-2+) confirmed the diagnosis of SFT. The patient recovered smoothly and was followed up for 12 months without tumor recurrence or complications. For selected patients with giant pelvic SFT, robot-assisted laparoscopic surgery appears to be a viable treatment option. This technique facilitates meticulous dissection and yields promising short-term clinical outcomes. However, long-term follow-up is required due to the potential for late recurrence of SFT. - Source: PubMed
Publication date: 2026/07/01
Wang BinbinHuang GengchenWei WeiMao TieGao ZihanMa YutaoGu Yiming - Allergic asthma is characterized by chronic airway inflammation that fails to resolve efficiently. Defective efferocytosis and metabolic reprogramming of macrophages are crucial factors in allergic diseases. While PKM2 is known to participate in phagocytosis and metabolism, its specific role in modulating asthma remains unclear. - Source: PubMed
Publication date: 2026/07/15
Chen LingliLiu YileChen YatingZhang YueYu LeiZhu YantongPeng WangWu MaolanZheng Xiangrong