Sarcoglycan Delta (SGCd), Human, ELISA Kit
- Known as:
- Sarcoglycan Delta (SGCd), Human, Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- G8918
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- Glory
- Gene target:
- Sarcoglycan Delta (SGCd) Human ELISA Kit
Related genes to: Sarcoglycan Delta (SGCd), Human, ELISA Kit
- Gene:
- DLK1 NIH gene
- Name:
- delta like non-canonical Notch ligand 1
- Previous symbol:
- -
- Synonyms:
- FA1, pG2, Pref-1, ZOG, Delta1
- Chromosome:
- 14q32.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-09
- Date modifiied:
- 2019-04-23
- Gene:
- SGCD NIH gene
- Name:
- sarcoglycan delta
- Previous symbol:
- -
- Synonyms:
- DAGD, LGMD2F, CMD1L
- Chromosome:
- 5q33.2-q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-22
- Date modifiied:
- 2019-04-23
Related products to: Sarcoglycan Delta (SGCd), Human, ELISA Kit
Related articles to: Sarcoglycan Delta (SGCd), Human, ELISA Kit
- Early postnatal growth is a critical determinant of meat production efficiency and long-term genetic improvement in goats; however, the molecular mechanisms underlying individual variation in growth performance remain poorly understood. In this study, a total of 123 Hechuan white goats were included. First, a genome-wide association study (GWAS) for average daily gain (ADG) was performed using all 123 individuals. Subsequently, based on the coefficient of variation of ADG (CV = 65.6%), an extreme phenotype sampling (EPS) strategy was applied to select 39 individuals with extreme growth phenotypes for subsequent metabolomic, microbiome, and integrated mGWAS analyses.The results showed that ADG approximately followed a normal distribution across the 123 goats. GWAS identified 22 loci significantly associated with ADG, mapping to genes including DLK1, NCAPG2, LCORL, CNTNAP2, and SLC8A1, which are involved in pathways related to skeletal muscle development, cell cycle regulation, ion transport, and immune function. Metabolomic profiling detected 1,589 putative metabolites, revealing differential enrichment of lipid, amino acid, and bile acid metabolic pathways between fast- and slow-growing goats. Gut microbiome analysis demonstrated that Christensenellaceae_R-7_group and Monoglobus were significantly enriched in fast-growing individuals, whereas Desulfovibrio was more abundant in slow-growing goats.Integrated mGWAS analysis further revealed extensive effects of host genetic variation on gut microbiota and fecal metabolites. Specifically, 11 bacterial genera were significantly associated with host genomic variants, among which Desulfovibrio exhibited the highest number of associated loci. Integration of multiple variant types consistently linked Desulfovibrio, Eubacterium_hallii_group, and Candidatus_Saccharimonas with genes such as ARHGAP24 and IGF2BP2. In addition, 14 metabolites were significantly associated with host genetic variants, with Lysopc(14:1(9Z)/0:0) and glycocholic acid showing the strongest associations. Notably, the peak signal for Lysopc was located within HMGA2.Collectively, these findings define a coordinated host genome-gut microbiota-metabolite network underlying early growth variation in goats and provide a mechanistic foundation for precision breeding and targeted nutritional strategies in goat production systems. - Source: PubMed
Publication date: 2026/07/11
Mou Hui-LongWang Zi-XuanZhang Ming-DingLiu Yao-LongRen TaoRuan Peng-ChengHan Yan-GuoZeng YanZhang Hao-YuanLu Jia-GuoZhang YangLiu Cheng-LiHuang Yong-FuZhao Yong-JuZhao Zhong-QuanPan XiaoZhou Li-PingCeccobelli SimoneE Guang-Xin - The neuropeptides kisspeptin and Delta-like 1 homolog (DLK1) regulate pubertal timing by activating and inhibiting the hypothalamic-pituitary-gonadal (HPG) axis, respectively. Given these opposing regulatory roles, quantifying serum kisspeptin and DLK1 levels during gonadotropin-releasing hormone (GnRH) stimulation may serve as novel biomarkers for distinguishing between central precocious puberty (CPP) and premature thelarche (PT) in girls. - Source: PubMed
Publication date: 2026/07/09
Paisansukanant KulpatraChatdamrongsakool KrittamateChotipakornkul NuntikaAroonpakmongkol SuphabWacharasindhu SuttipongSupornsilchai VichitSrilanchakon Khomsak - Mouse embryonic stem cell (ESC) cloning via nuclear transfer is a potential platform for direct generation of genetically modified mice. However, the low G1 cell population in ESCs hampers their broader use in nuclear transfer, as S-phase donors induce 1-cell arrest in reconstructed oocytes. This study aimed to enrich the G1-phase population of ESCs to improve ESC-based cloning efficiency. We demonstrated that EB3 ESCs derived from the 129/Ola strain and C57BL/6×129/Sv hybrid ESCs exhibited superior traits for nuclear transfer in terms of cleavage rate and blastocyst formation but showed reduced efficiency in development to term. Transcriptomic analyses revealed that this failure was likely due to aberrant imprinted gene expression in critical clusters, such as H19-Igf2 or Dlk1-Dio3. In contrast, although cloned offspring were successfully generated at a promising rate (approximately 6%) using EGR-R01 (BDF1×129/Sv) ESCs, early cleavage to the 2-cell embryo was inefficient. To address this, we induced cell cycle synchronization by culturing ESCs to overconfluency, which markedly increased the G1 proportion, as confirmed via FACS analysis. This alteration led to a significant improvement in first cleavage efficiency without compromising the developmental potential of ESC-derived cloned embryos to live birth. Overall, our study highlights the importance of both cell cycle synchronization and imprinting maintenance in improving ESC cloning efficiency to facilitate broad applications, including the direct generation of genetically modified mice. - Source: PubMed
Publication date: 2026/07/09
Pham Dinh QuocMatoba ShogoFunaya SatoshiHirose MichikoIke FumioIsotani AyakoOgonuki NarumiIkawa MasahitoVAN Thuan NguyenOgura AtsuoInoue Kimiko - Osteoporosis (OP) is a multifactorial skeletal disorder marked by reduced bone mass and microstructural deterioration. We investigated potential diagnostic biomarkers and immunometabolic targets through integrated bioinformatics and machine learning analysis. - Source: PubMed
Publication date: 2026/06/30
Ding Kai-KaiZhang YuYang NingHou Jing-YiZhu Nai-Qiang - is a paternally expressed gene encoding a transmembrane protein belonging to the Delta-Notch signaling family, increasingly recognized for its role in fetal growth regulation. This study explores the relationship between genetic variants (SNV) and birth weight and the potential sex-specific differences in this association. This cross-sectional study consists of a sample of 949 participants (499 males and 450 females) with available birth weight information obtained from official birth certificates. Five SNVs located within or near the gene (rs1802710, rs876374, rs7155375, rs57098752, and rs7149242) were genotyped using Real-Time PCR with predesigned TaqMan™ Assays. Three SNVs (rs1802710, rs876374 and rs7149242) were significantly associated with birth weight in males, but not in females. Interestingly, heterozygous males had a higher mean birth weight than homozygous males. Further confirming this association, heterozygotes for these SNVs were more frequent among males with birth weight above the population mean (3.4 kg) compared to those below it. variants are associated with birth weight in a sex-dependent manner and with an inheritance pattern compatible with polar overdominance. This places as a genetic factor to be considered when evaluating health conditions related to higher or lower than normal birth weight. - Source: PubMed
Publication date: 2026/06/18
Pomares OlgaPérez-Nadador IrisMejorado-Molano Francisco JParra-Rodríguez AlejandroSoriano-Guillén LeandroLaborda JorgeGarcés Carmen