Xtreme Efficiency DH10
- Known as:
- Xtreme Efficiency DH10
- Catalog number:
- ABP-CE-XDHE050
- Product Quantity:
- 50 X 60uL
- Category:
- -
- Supplier:
- Allele
- Gene target:
- Xtreme Efficiency DH10
Related genes to: Xtreme Efficiency DH10
- Gene:
- ALDH3A2 NIH gene
- Name:
- aldehyde dehydrogenase 3 family member A2
- Previous symbol:
- SLS, ALDH10
- Synonyms:
- FALDH
- Chromosome:
- 17p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1996-06-14
- Date modifiied:
- 2018-05-03
Related products to: Xtreme Efficiency DH10
*Microbial Content Test Agar (Tryptone Soya Agar w_Tween 80 & Lecithin) USE For determining efficiency of sanitization of containers, equipment surfaces,water miscible cosmetics etc.*Tryptone Soya Agar w_Lecithin & Tween 80 USE For determining efficiency of sanitization of containers, equipment surfaces, water miscible cosmetics etc.Competent Cells, Bronze EfficiencyCompetent Cells, Bronze EfficiencyCompetent Cells, Bronze EfficiencyCompetent Cells, Gold EfficiencyCompetent Cells, Gold EfficiencyCompetent Cells, Gold EfficiencyCompetent Cells, Gold Efficiency (T1 Resistant Cells)Competent Cells, Gold Efficiency (T1 Resistant Cells)Competent Cells, Silver EfficiencyCompetent Cells, Silver EfficiencyCompetent Cells, Silver EfficiencyCompetent Cells, Silver Efficiency (T1 Resistant Cells)Competent Cells, Silver Efficiency (T1 Resistant Cells) Related articles to: Xtreme Efficiency DH10
- To describe crystalline maculopathy as a diagnostic clue to Sjögren-Larsson syndrome (SLS) and highlight characteristic multimodal imaging findings. - Source: PubMed
Publication date: 2026/09/22
Tang TinaBallios Brian - The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of the cellular antioxidant response that defends against ferroptosis and facilitates tumour development. Here, by performing an aldehyde dehydrogenase (ALDH) family shRNA screen, our study identifies aldehyde dehydrogenase 3 family member A2 (ALDH3A2) as a potent NRF2 activator that inhibits ferroptosis. Interestingly, ALDH3A2 efficiently activates NRF2 in both wild-type (WT) Kelch-like ECH-associated protein 1 (KEAP1) and mutant KEAP1 tumour cells. Mechanistically, ALDH3A2 inhibits the phosphorylation of glycogen synthase kinase 3 beta (GSK3β) and blocks recruitment of E3 ubiquitin ligase beta-transducin repeat-containing protein (BTRC) to NRF2, thereby stabilizing NRF2 by preventing its proteasomal degradation. Knockdown of ALDH3A2 significantly promotes the activation of the GSK3β signaling pathway and accelerates NRF2 degradation. ALDH3A2 stabilizes NRF2 independently of its enzymatic activity, as enzymatic inactivation of ALDH3A2 fails to block ALDH3A2-mediated NRF2 activation and ferroptosis suppression both in vitro and in vivo. Taken together, our study reveals a novel NRF2 regulatory pathway and suggests ALDH3A2 as a promising druggable target for KEAP1-mutant tumours. - Source: PubMed
Publication date: 2026/08/17
Yang LiZhuang XiaoHan JingCui WeiweiZhang YudanWang ZiqiSong DandanZhou ChaoHuang ShaohuiCui KaiLin ChenchenXu MinZhao XingruWang ShuaiHuang BinWang HuiShi ShuangDu LutaoLuo QiankunZhang QunchengMa ZehengYin ChengqianChu BoZhang Xiaoju - Extremely rare cases show co-occurrence of Sjogren-Larsson syndrome (SLS) and central precocious puberty (CPP), and our understanding of it is still limited. In this case report, we reported a 9-year-old boy (weight: 20 kg; height: 120 cm) showing SLS and CPP simultaneously. The patient presented to our hospital with testicle enlargement and presence of pubic hair. SLS was diagnosed based on the presence of ichthyosis and intelligent disability, together with genetic confirmation by next-generation sequencing, which identified two pathogenic variants ( and ) in the gene. The diagnosis of CPP was established based on mildly advanced bone age, ultrasonographic evidence of pubertal development, and elevated basal gonadotropin and testosterone levels. The patient subsequently received triptorelin acetate (3.75mg) for treating CPP, while merely moisturization and rehabilitation was used for treating SLS. In the follow-up, he showed growth delay, with a body height of 120 cm at age 8.5 years old and 123.5 cm at 9.5 years old. - Source: PubMed
Publication date: 2026/07/21
Zhao CanmiaoTao NaGe LipingSun MeiyuanSu YanfangYang YangXu FangHuang QiXu Lijun - To characterize the clinical features and genetic spectrum of Chinese patients with Sjögren-Larsson syndrome (SLS). - Source: PubMed
Publication date: 2026/07/16
Chen FengYu BowenWang YangshuoYuan LiuZhang LiweiLiu TinghongZhai FengXu JinshanNi XinLiang Shuli - Endometritis is an inflammatory endometrium condition affecting reproductive outcomes. However, the pathology of endometritis is poorly understood. Thus, we attempted to investigate the pathogenic mechanism of endometritis and discover potential biomarkers. Transcriptome sequencing was performed on endometritis patient-derived endometrial tissues (n = 3) and normal controls (n = 5). Differentially expressed genes (DEGs) between disease and control groups were identified. Mitochondrial genes were filtered based on MitoCarta3.0. Small RNA sequencing (9 disease samples vs. 6 controls) was combined with differentially expressed (DE) mitochondrial genes to generate a competing endogenous RNA (ceRNA) network, followed by protein-protein interaction network analysis. Metabolome analysis was conducted to explore differentially expressed metabolites (4 cases vs. 4 controls). Comparative analysis revealed a total of 1,507 DEGs in disease group relative to controls, which were implicated in adaptive immune response, cell chemotaxis, and chemotaxis signaling pathways. In total, 28 mitochondrial genes were differentially expressed and mapped to the ceRNA network. ALDH3A2, ACSS3, CYP24A1, and KMO were identified as hub genes and were closely associated with the infiltration of CD8 T cells. CYP24A1 was found to be the target of four drugs, including calcitriol and deferasirox. Five metabolic pathways were significantly enriched, including the citrate cycle (TCA cycle) and taurine and hypotaurine metabolism. ALDH3A2, ACSS3, and KMO showed interactions with metabolites and significant pathways. Hub genes (ALDH3A2 and ACSS3) play critical roles in the pathogenesis of endometritis by interacting with different metabolites. Our study offers candidate biomarkers for diagnosing and treating endometritis. - Source: PubMed
Publication date: 2026/07/15
Xu AnranChen YanyanZheng YanjunWen YanSun YanyanDong FangdiYang HuijunFan YuanyuanYu Xuan