Rat MIP-3a ELISA kit
- Known as:
- Rat MIP-3a Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- LF-EK50673
- Product Quantity:
- 1
- Category:
- Elisa Kits
- Supplier:
- Abfron
- Gene target:
- Rat MIP-3a ELISA kit
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- Keloid is a cutaneous fibrotic disorder characterized by excessive fibrous tissue proliferation during wound healing. Tolerogenic dendritic cells (tolDCs) may participate in keloid immunopathology, but the related molecular signatures remain unclear. This study aimed to identify candidate tolDC-associated genes in keloid by integrating tolDC-related transcriptomic profiles with keloid transcriptomic datasets. - Source: PubMed
Publication date: 2026/09/21
Sun ZhongyangGao XuejieRen RongxinZhao Hongyi - Infertility remains a global health challenge that often necessitates invasive and costly diagnostic procedures. While the vaginal microenvironment is known to influence reproductive health, its potential as a source of non-invasive biomarkers for infertility remains insufficiently explored. This study integrated vaginal microbiome and inflammatory proteomic profiling using machine learning to develop and validate an objective, non-invasive diagnostic model for identifying women at high risk of infertility. - Source: PubMed
Publication date: 2026/09/11
Feng YangkunZhang YuChen DandanWang AifenLiu ZhenxingZhang YunYu Ruixi - () belongs to the genus of the family. In goats, infection can result in respiratory diseases such as pneumonia and bronchopneumonia. In this study, caprine bronchial epithelial cells were infected with , and multi-omics integration analysis was conducted to investigate the immune defense mechanisms triggered by the infection. Enrichment analysis of differentially expressed genes (DEGs) using the KEGG database revealed that immune-related signaling pathways involving TNF and IL-17 were among the top 20 most enriched. Based on the TNF and IL-17 signaling pathways, ten immune pathway-related genes, including , , , , , , , , , and , were selected for RT-qPCR validation. In addition, four miRNAs targeting genes involved in the above pathways, namely chi-miR-148a-5p, miR-1285-z, miR-16-x, and miR-6119-x, were verified by RT-qPCR. The expression trends of chi-miR-148a-5p and miR-1285-z were consistent with microRNA sequencing results. Furthermore, gain- and loss-of-function experiments indicated that chi-miR-148a-5p may target and , while miR-1285-z may target , with predicted as a potential target. This study suggests that chi-miR-148a-5p and miR-1285-z may participate in the TNF and IL-17 signaling pathways by regulating their predicted target genes. Moreover, the TNF and IL-17 signaling pathways are among the most highly enriched immune-related pathways involved in the innate immune response of caprine bronchial epithelial cells. This study provides insights into the molecular mechanisms underlying immune responses in goats infected with . - Source: PubMed
Publication date: 2026/09/12
Chen YimeiGong ZhenxingJing HuiDuan HaoQian HejieLi TengjiaoNiu ShihuaWu LiliWang ZiyingZhang MengqiCheng YiwenMan ChurigaChen QiaolingDu LiChen SiGao HongyanWang Fengyang - Psoriasis is a chronic skin disease manifesting scaly, indurated erythema and an enhanced interleukin (IL)-23/IL-17 immune axis. A high-salt diet (HSD) is known to promote several autoimmune or autoinflammatory diseases. We examined whether an HSD might exacerbate topical imiquimod (IMQ)-induced psoriasis-like dermatitis in mice. Balb/c female mice were fed a normal diet (ND, 0.2% NaCl) or an HSD (4.2% NaCl) for 3 weeks, and 25 mg IMQ was applied to shaved back skin for 5 consecutive days. Compared to ND, the HSD exacerbated IMQ-induced psoriasiform dermatitis with increased scale, skin thickness, and total scores, and histologically enhanced epidermal thickening, hyperkeratosis, and dermal inflammatory infiltrates, including Ly6G+ neutrophils and CD3+ T cells. HSD increased mRNA levels of , , , , , , , , , and in IMQ-induced dermatitis. HSD increased the immunostaining areas of whole and Ser 422-phosphorylated forms of serum- and glucocorticoid-inducible kinase 1 (SGK1) in epidermal keratinocytes and dermal-infiltrating cells in IMQ-induced dermatitis. Intraperitoneal SGK1 inhibitor EMD638683 reversed the above effects of HSD in exacerbating IMQ-induced dermatitis. Our present results indicate that HSD may exacerbate murine IMQ-induced psoriasis-like dermatitis at least partially through the activation of SGK1. - Source: PubMed
Publication date: 2026/09/13
Yoshida MaiHagino TeppeiYoneyama ManamiSaeki HidehisaKanda Naoko - MUC13 is a membrane-bound mucin involved in epithelial protection and barrier maintenance, but its role in nasal epithelial inflammation remains unclear. This study aimed to investigate whether MUC13 regulates inflammatory signaling in primary nasal epithelial cells (NECs). - Source: PubMed
Publication date: 2026/09/24
Zhou JiewenZhang XinyuLi MinZou YuGong YuwenZhao MengqiLi JianWen WeipingZheng Nianzhen