Rat IL-6 ELISA kit
- Known as:
- Rat Interleukin-6 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- LF-EK50651
- Product Quantity:
- 1
- Category:
- Elisa Kits
- Supplier:
- Abfron
- Gene target:
- Rat IL-6 ELISA kit
Related genes to: Rat IL-6 ELISA kit
- Gene:
- CEBPB NIH gene
- Name:
- CCAAT enhancer binding protein beta
- Previous symbol:
- TCF5
- Synonyms:
- LAP, CRP2, NFIL6, IL6DBP, C/EBP-beta
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1991-02-27
- Date modifiied:
- 2018-02-23
- Gene:
- CEBPD NIH gene
- Name:
- CCAAT enhancer binding protein delta
- Previous symbol:
- -
- Synonyms:
- CRP3, CELF, C/EBP-delta, NF-IL6-beta
- Chromosome:
- 8q11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-24
- Date modifiied:
- 2018-02-23
- Gene:
- ENTPD6 NIH gene
- Name:
- ectonucleoside triphosphate diphosphohydrolase 6
- Previous symbol:
- CD39L2, IL6ST2
- Synonyms:
- NTPDase-6, dJ738P15.3
- Chromosome:
- 20p11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-20
- Date modifiied:
- 2019-02-28
- Gene:
- IL6 NIH gene
- Name:
- interleukin 6
- Previous symbol:
- IFNB2
- Synonyms:
- IL-6, BSF2, HGF, HSF
- Chromosome:
- 7p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2017-07-12
- Gene:
- IL6RP1 NIH gene
- Name:
- interleukin 6 receptor pseudogene 1
- Previous symbol:
- IL6RL1
- Synonyms:
- -
- Chromosome:
- 9q22.2
- Locus Type:
- pseudogene
- Date approved:
- 1991-08-18
- Date modifiied:
- 2014-11-19
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- Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people face significant stigma, a structural and social determinant of health that contributes to persistent health disparities. Minority stress theory proposes that both proximal and distal stressors adversely impact health and well-being, while protective factors act as buffers. This study aims to identify mechanisms through which minority stress and protective factors influence physical and mental health in LGBTQ+ adults and to determine whether these processes differ across subgroups as well as in comparison to cisgender heterosexual adults. We hypothesize that greater levels of minority stress will be linked to increased AL, decreased microbiota diversity, and diminished cognitive performance. We further hypothesize that protective factors will moderate these associations. - Source: PubMed
Publication date: 2026/09/18
Hogan RyanChuntova NevenaAit Abdelmalek InèsLavallée-Rodrigue KarineThériault Emma-RoseGuenoun ZiadBoulette JasmineCoveny VasilisaCastillo-Nehme AzulMassicotte SamuelGauthier LaurianneSavard DominiqueTunc AralLeclair Julie LecoursMechawar FlorenceCotocea IoanaJacmin-Park SilkeBorduas-Pagé StéphanieJuster Robert Paul - Uveitis is a sight-threatening disease in which autoimmune and inflammatory reactions play a central role. This study aimed to identify key genes involved in the pathogenesis of uveitis using bioinformatics approaches and to validate their expression in a rat model of experimental autoimmune uveitis (EAU). The GSE66936 microarray dataset, comprising transcriptomes of CD14 and CD16 monocytes from five patients with uveitis and four healthy donors, was downloaded from the Gene Expression Omnibus, and known uveitis-related targets were retrieved from six disease-gene databases. Differentially expressed genes (DEGs) were identified and subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. A protein-protein interaction network was constructed using STRING, and hub genes were screened with Cytoscape and evaluated by receiver operating characteristic (ROC) curve analysis. EAU was induced in Sprague-Dawley rats by immunization with interphotoreceptor retinoid-binding protein (IRBP), and ocular inflammation was assessed by slit-lamp examination and histopathology. The expression of the hub genes was validated in ocular, liver, and spleen tissues by reverse transcription-quantitative polymerase chain reaction and enzyme-linked immunosorbent assay. A total of 139 uveitis-related genes were identified; these were enriched in inflammatory response, immune response, viral defense response, and the TNF and NF-κB signaling pathways. Ten hub genes (IL17A, IL18, TLR2, IL2, TLR4, IL10, IL1B, IL6, TNF, and CCL2) were identified, each with an area under the ROC curve greater than 0.6. The EAU model was successfully established, with significantly greater anterior segment inflammation than in controls, and the mRNA and protein levels of the hub genes were significantly elevated in the ocular and peripheral tissues of EAU rats (p < 0.05). These findings reveal key genes and pathways involved in the pathogenesis of uveitis and provide candidate targets for its diagnosis and treatment. - Source: PubMed
Publication date: 2026/09/21
He KunPan BingxinTian PengfeiYang Suyun - Hypoxic conditions in the tumor microenvironment, which escape immune surveillance, are a major hindrance to controlling the antitumor effect of nanomaterials. In this work, MXene/MoS2 @M.bvs photoactive live bacteria were developed. NIR irradiation elevates the oxygen level, induces the photothermal effect, interferes with the Ado A2A receptor (Adenosine A2AR) metabolic pathway, and triggers cancer immunotherapy. An acid-etched MXene sheet was fabricated from the MAX phase; exfoliated MoS2 was composited with a thin MXene sheet to form self-assembled MXene/MoS2. Nanocomposites were conjugated to Mycobacterium bovis (M.bvs) through a carbodiimide reaction, and they formed a stable rod shape, as confirmed through HRTEM analysis. The in vitro catalytic effect of MXene/[email protected] toward H2O2 was evaluated, and a reduction of the Ado level was observed by downregulation of A2AR expression. Nanocomposites not only improved the photothermal effect but also were directly involved in the immune stimulation. The level of cytokine production and cytotoxic T-cell activation was higher for MXene/[email protected] compared to the MXene/MoS2. In vivo studies showed that MXene/[email protected] + NIR exhibited higher antitumor activity, longer survival time, biosafety, and inhibition of tumor growth. It also promotes DC maturation, increases TNF-α and IL-6, and induces a potent antitumor immune response. Overall, the photoactive live bacterial nanocomposites effectively enhance the synergistic effect of photothermal cancer immunotherapy. - Source: PubMed
Publication date: 2026/09/21
Ambigaibalan Ammavasi ChandranMehnath SivarajDharshini KannaiyakumarPonbharathi ArivalaganSowndharya Chithaiyan KamaladeviJeyaraj Murugaraj - Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease with complex pathogenesis and limited treatments. Hemp seed oil, with its unique ω-6/ω-3 polyunsaturated fatty acid ratio and phenolic antioxidants, exhibits anti-inflammatory and gut barrier-enhancing properties, though its mechanisms in UC are not fully understood. Here, we applied an integrated transcriptomics and metabolomics approach to investigate the effects of hemp seed oil in dextran sulfate sodium (DSS)-induced UC mice. Treatment with hemp seed oil (1 g/kg) significantly alleviated disease activity, suppressed proinflammatory cytokine levels (interleukin (IL)-6, IL-1β, and IL-17), and improved colonic histopathology. Metabolomic profiling via ultrahigh-performance liquid chromatography-quadrupole-orbitrap tandem mass spectrometry (UPLC-Q-Orbitrap MS/MS) identified 19 significantly altered colonic metabolites, predominantly involved in amino acid metabolism, energy homeostasis, and lipid signalling pathways. Transcriptomic analysis suggested that hemp seed oil treatment was associated with inhibition of the IL-17 and tumor necrosis factor (TNF) signalling pathways while upregulating genes involved in barrier function (e.g., zonula occludens-1 (ZO-1) and Occludin). Integrative analysis revealed strong inverse correlations between key metabolites (e.g., docosahexaenoic acid ethyl ester, adenosine diphosphate (ADP)) and IL-17 pathway activation (IL17A, C-X-C motif chemokine ligand 10 (CXCL10)), suggesting that hemp seed oil may attenuate UC through reprogramming the "metabolism‒inflammation" axis. These findings suggest potential multitarget therapeutic mechanisms of hemp seed oil against UC, indicate critical links between metabolic reprogramming and the immune‒inflammatory axis, and offer novel insights for the development of phytomedicine for the treatment of inflammatory bowel disease. - Source: PubMed
Publication date: 2026/09/21
Zhang YujieGuan YiyunZhou JunjieYang JingLu HailongLi LixiZou ZhongjieGong Mengjuan - Cisplatin is among the most widely used chemotherapeutic drugs for the treatment of solid tumors; nonetheless, nephrotoxicity persists as a significant dose-limiting adverse effect. The current study focuses on the protective effect of propolis against cisplatin-induced kidney damage in experimental rats. Nephrotoxicity was induced by a single intraperitoneal injection of cisplatin at a dose of 5 mg/kg, ip, followed by propolis oral administration. The chemical profile of the propolis extract was characterized using liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). Biochemical parameters of renal function (urea and creatinine), oxidative stress markers (MDA, SOD, CAT and GSH), proinflammatory markers (IL-6, TNF-α and IL-1ꞵ) and RT-PCR were performed along with histopathological and immunohistochemical investigations. LC-MS analysis revealed that the propolis contained several bioactive phenolic acids and flavonoids, with pyrocatechol, iso-ferulic acid, gallic acid, apigenin, kaempferol, quercetin, which may contribute to the antioxidant and nephroprotective effects of propolis. The results demonstrated that cisplatin markedly increased serum levels of urea and creatinine and elevated lipid peroxidation and inflammation, accompanied by notable damage in renal structure. Conversely, propolis treatment significantly ameliorated these adverse effects by restoring antioxidant status, reducing oxidative stress and improving histological structure. Furthermore, administration of propolis significantly suppressed inflammation by reducing proinflammatory cytokines levels and the expression of caspase-3. In addition, immunohistochemical results revealed that propolis treatment markedly increased Nrf2/HO-1 expression in kidney tissue. In conclusion, these findings suggested that propolis exerts nephroprotective effects against cisplatin-induced nephrotoxicity via its anti-inflammatory and antioxidant activities. - Source: PubMed
Publication date: 2026/09/21
Fallatah AlyahEssam AlaaEl-Beltagy Abd El-Fattah B MAbdelghany Amr MSalah Neven A