IRS-1 Antibody (Phospho-Ser636), pAb, Rabbit
- Known as:
- IRS-1 Antibody (Phospho-Ser636), pAb, Rabbit
- Catalog number:
- A00503-100
- Product Quantity:
- 100,0μg
- Category:
- -
- Supplier:
- Genscript
- Gene target:
- IRS-1 Antibody (Phospho-Ser636) pAb Rabbit
Related genes to: IRS-1 Antibody (Phospho-Ser636), pAb, Rabbit
- Gene:
- IL20RB NIH gene
- Name:
- interleukin 20 receptor subunit beta
- Previous symbol:
- FNDC6
- Synonyms:
- DIRS1, IL-20R2, MGC34923
- Chromosome:
- 3q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-23
- Date modifiied:
- 2015-12-11
- Gene:
- IRS1 NIH gene
- Name:
- insulin receptor substrate 1
- Previous symbol:
- -
- Synonyms:
- HIRS-1
- Chromosome:
- 2q36.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-24
- Date modifiied:
- 2016-10-05
- Gene:
- KRT71 NIH gene
- Name:
- keratin 71
- Previous symbol:
- -
- Synonyms:
- KRT6IRS, KRT6IRS1, K6IRS1
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2006-07-17
- Date modifiied:
- 2016-03-09
Related products to: IRS-1 Antibody (Phospho-Ser636), pAb, Rabbit
Related articles to: IRS-1 Antibody (Phospho-Ser636), pAb, Rabbit
- The global increase in Type 2 diabetes (T2D) presents a serious public health challenge. Lonicera japonica Thunb., a traditional medicinal and edible plant, is a rich source of caffeoylquinic acids (CQAs), which are naturally occurring polyphenols that have drawn considerable research interest due to their diverse biological activities, particularly their potential in the management of T2D. In this study, six CQAs were isolated from the flower buds of L. japonica using preparative HPLC, with a total yield of 0.0555 mg/g. These compounds were identified as 3-CQA, 4-CQA, 5-CQA, 3,4-DCQA, 3,5-DCQA, and 4,5-DCQA, and their structures were characterized by LC-DAD-ESI-QTOF-MS and NMR. Hypoglycemic activity was then assessed using α-glucosidase/α-amylase inhibition, glucose uptake, and hepatic glucose production assays. Network pharmacology predicted potential targets and pathways, which were then validated by dual-luciferase reporter and Western blot analyses. Results showed that CQAs selectively inhibited α-glucosidase (not α-amylase), enhanced glucose uptake, and suppressed hepatic glucose production. Among them, the di-CQAs, particularly 4,5-DCQA and 3,5-DCQA, were the most potent α-glucosidase inhibitors, with IC₅₀ values of 5.49 and 7.96 mM, respectively. Network analysis identified AKT1, PEPCK, and INSR as core targets, and PI3K/AKT, insulin, and FoxO signaling pathways as key pathways. Mechanistically, 3,5-DCQA suppressed gluconeogenesis by inhibiting PEPCK (at both promoter activity and protein levels) and downregulating CREB. It also enhanced insulin signaling via upregulation of INSR, IRS-1, and p-AKT. In conclusion, our study demonstrates that 3,5-DCQA, a key bioactive constituent of L. japonica, exerts multitarget hypoglycemic effects by coordinately regulating gluconeogenesis and insulin signaling. These findings not only provide a direct pharmacological basis for the antidiabetic potential of CQA-rich herbs but also highlight 3,5-DCQA as a promising candidate for developing novel therapeutics or adjuncts for T2D management. - Source: PubMed
Ye YiyiXu DaweiZhang ShiluYu HuaweiLiu YingweiYang JinSun Lijuan - Obesity is associated with insulin resistance, a major risk factor for type 2 diabetes (T2D), yet the underlying mechanisms remain incompletely defined. We hypothesized that elevated transforming growth factor beta 1 (TGFβ1) level is associated with impaired insulin sensitivity. - Source: PubMed
Publication date: 2026/05/28
Ai WeiqiPan QuanShen ZhengYang WanbaoJiang WenSong JianxunGuo Shaodong - Largemouth bass () is an economically important aquaculture species, but its pronounced intolerance to high-carbohydrate diets often leads to metabolic liver disorders and compromised growth, limiting the practical application of cost-effective high-carbohydrate feeds in aquaculture. Lipid nanoparticles (LNPs) have shown promise in regulating glucose metabolism in mammals, but their efficacy and size-dependent effects in fish remain unelucidated. - Source: PubMed
Publication date: 2026/05/27
Zhang KaipengZhu TengfeiWang YaminChen JingXie ShanLin ZhenyeChen XiaotongYu YingyingXu Yining - Inadequate choline intake-induced choline metabolic stress (CMS) has been divergently linked to metabolic dysfunction-associated steatotic liver disease (MASLD), yet underlying mechanisms remain unclear. We hypothesized that CMS modifies plasma-free amino acid (PFAA) signatures to influence MASLD risk. In a nested case-control study of 125 participants, dietary choline intake and blood choline metabolites were assessed together with targeted metabolomics and transcriptomic profiling. MASLD was characterized by low choline intake, reduced plasma betaine/choline ratio (Pbcr), elevated homocysteine, increased branched-chain amino acids (BCAAs), and depleted serine/glycine, achieving strong predictive accuracy (AUC = 0.90). CMS was associated with reduced lymphocytic transcripts involved in BCAA catabolism and altered mTORC1/Akt/IRS1 signaling. Nonlinear Pbcr- and intake-dependent MASLD risk patterns were attenuated after adjustment for genetic-metabolite networks. These findings identify CMS-responsive metabolic mediators supporting precision choline interventions. - Source: PubMed
Publication date: 2026/05/08
Wu Chien-HsienLin Ming-LuWang Chao-YunChang Chi-YangLee Fu-JenCheng Mei-LingLin Yu-ShunChen Tong-WeiHsiao Yi-TingWang Bei-WenKuo Chang-ShengHuang Rwei-Fen S - Prostate cancer is a heterogeneous disease with variable clinical outcomes. If localized, the patient may be cured. However, prostate cancer is lethal if recurrence/progression to metastatic castrate resistant disease occurs. Thus, there is an unmet need to further understand the molecular underpinnings of this progression. Epidemiologic studies show that increased risk of developing and dying from prostate cancer has been associated with elevated serum IGF-1 levels, hyperinsulinemia and metabolic syndrome. Alterations in insulin pathway genes, such as , , and , are mutated in up to 32%, 15%, and 11% of localized prostate tumors, respectively. We aimed to further characterize expression of insulin pathway genes in localized prostate cancers in an effort to (1) provide insights into potential mechanisms of progression to metastatic disease and (2) try to further enrich for those prostate tumors that portend worse survival outcomes. - Source: PubMed
Publication date: 2026/05/19
Adler Evan RMohammad AnwaruddinKumar PankajRounbehler Robert JChurchman Michelle LGraham Laura SSinger Eric ASalhia BodourAyanambakkam AdanmaNepple Kenneth GMyint Zin WLi QiangGhodoussipour SaumKing Jennifer MGrass G DanielGupta Sumati VViscuse Paul V