Interleukin-8 (IL-8) CXCL8, Human
- Known as:
- Interleukin-8 (Interleukin-8) CXCL8, Human
- Catalog number:
- Z03061-10
- Product Quantity:
- 10,0ug
- Category:
- -
- Supplier:
- Genscript
- Gene target:
- Interleukin-8 (IL-8) CXCL8 Human
Related genes to: Interleukin-8 (IL-8) CXCL8, Human
- Gene:
- CXCL8 NIH gene
- Name:
- C-X-C motif chemokine ligand 8
- Previous symbol:
- IL8
- Synonyms:
- SCYB8, LUCT, LECT, MDNCF, TSG-1, IL-8, NAP-1, 3-10C, MONAP, AMCF-I, LYNAP, NAF, b-ENAP, GCP-1, K60, GCP1, NAP1
- Chromosome:
- 4q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2016-10-05
- Gene:
- CXCR1 NIH gene
- Name:
- C-X-C motif chemokine receptor 1
- Previous symbol:
- CMKAR1, IL8RA
- Synonyms:
- CKR-1, CDw128a, CD181
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-09
- Date modifiied:
- 2016-03-14
- Gene:
- CXCR2 NIH gene
- Name:
- C-X-C motif chemokine receptor 2
- Previous symbol:
- IL8RB
- Synonyms:
- CMKAR2, CD182
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-19
- Date modifiied:
- 2016-03-14
- Gene:
- CXCR2P1 NIH gene
- Name:
- C-X-C motif chemokine receptor 2 pseudogene 1
- Previous symbol:
- IL8RBP, CXCR2P
- Synonyms:
- -
- Chromosome:
- 2q35
- Locus Type:
- pseudogene
- Date approved:
- 1992-11-27
- Date modifiied:
- 2016-03-14
Related products to: Interleukin-8 (IL-8) CXCL8, Human
Related articles to: Interleukin-8 (IL-8) CXCL8, Human
- Therapy-induced senescence (TIS) is a major component of tumor cell response to a variety of anticancer treatments in preclinical models. Most TIS-related literature is derived from 2D-based studies with limited evidence in 3D models. This study aimed to investigate the challenges of developing an in-house (DIY) 3D bioprinted TIS cell model. - Source: PubMed
Publication date: 2026/06/19
Al Shboul SofianAl Dweiri YazanAlSakhen Mai FHimsawi NisreenAl Zain HelenAl Hadidi SabalBarham RaghdaAbabneh Nidaa AKhasawneh Ashraf IAlotaibi Moureq RTahtamouni Lubna HSaleh Tareq - Increasing evidence highlights the critical role of gut microbiota diversity in maintaining systemic homeostasis; however, the mechanisms by which microbiota-derived metabolites regulate host targets remain incompletely understood. Intervertebral disc degeneration (IDD) is strongly associated with chronic inflammation and metabolic dysregulation. This study employed a network pharmacology approach to elucidate metabolite-target interactions underlying the gut-disc axis. - Source: PubMed
Publication date: 2026/06/22
Liu HangZhang ShuaiYao DengboWang YuKong Qingquan - The liver is pivotal in the metabolic and innate immune responses of sepsis, managing bacteremia, cytokine regulation, and acute-phase protein synthesis. However, the liver's susceptibility to damage during sepsis underscores the need to understand the mechanisms behind septic liver injury. Our objective was to apply bioinformatics to identify key genes and pathways involved in septic liver injury and to reveal potential therapeutic targets. - Source: PubMed
Yang YanLv JingChu JianfengSong GuobinSun ShujunChen Rui - Perineural invasion (PNI) is common in gastric cancer and predicts poor prognosis, but the molecular mechanisms underlying tumour-nerve crosstalk remain unclear. - Source: PubMed
Publication date: 2026/06/22
Li XunjunZhai ZhongyaYu HaiyiQiu RenjieLi FengyuXiao LuxiHuang BoxiLiu HuiyingHe JiayongCai BowenChen JiawenYu JiangLi GuoxinChen Tao - Dental microbrushes are widely used in adhesive and restorative dentistry; however, flocked nylon designs have been reported to release fibers during clinical manipulation. While such remnants have been discussed in the context of bonding integrity, their potential biological impact on adjacent oral soft tissues remains unclear. The present study investigated the cytotoxic and inflammatory effects of commercially available flocked nylon and elastomer-based dental microbrushes on primary human gingival fibroblasts and HSC-2 oral epithelial cells. Cells were exposed to six microbrush types under direct contact conditions for 24 h. Cell viability was assessed by MTT assay and trypan blue exclusion. Inflammatory activation was evaluated by reverse transcription-quantitative PCR analysis of IL6, IL8 (CXCL8), CCL8, and CCL20 expression, CXCL8 protein quantification by ELISA, and immunofluorescence analysis of NF-κB p65 nuclear translocation. Pro-inflammatory stimulation with IL-1β and TNF-α served as a positive control. None of the tested microbrushes significantly reduced cell viability or induced transcriptional upregulation of inflammatory mediators. CXCL8 protein secretion remained unchanged, and NF-κB signaling was not activated following microbrush exposure. In contrast, cytokine stimulation robustly induced inflammatory responses, confirming the sensitivity of the experimental model. Within the limitations of this in vitro model, commercially available dental microbrushes did not trigger measurable cytotoxicity or pro-inflammatory signaling in oral soft tissue cells. These findings support the short-term biological compatibility of the investigated materials while highlighting the need for further studies addressing chronic exposure, inflammatory priming, and immune cell involvement. - Source: PubMed
Publication date: 2026/06/22
Andersson Lars Raphael ChristianGruber ReinhardPanahipour Layla