Human IL-5 ELISA kit
- Known as:
- Human Interleukin-5 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- LF-EK50649
- Product Quantity:
- 1
- Category:
- Elisa Kits
- Supplier:
- Abfron
- Gene target:
- Human IL-5 ELISA kit
Related genes to: Human IL-5 ELISA kit
- Gene:
- CSF2RB NIH gene
- Name:
- colony stimulating factor 2 receptor beta common subunit
- Previous symbol:
- IL3RB
- Synonyms:
- IL5RB, CD131, betaGMR
- Chromosome:
- 22q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-07
- Date modifiied:
- 2017-07-12
- Gene:
- IL5 NIH gene
- Name:
- interleukin 5
- Previous symbol:
- -
- Synonyms:
- IL-5, EDF, TRF
- Chromosome:
- 5q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2015-07-06
- Gene:
- IL5RA NIH gene
- Name:
- interleukin 5 receptor subunit alpha
- Previous symbol:
- IL5R
- Synonyms:
- CDw125, CD125
- Chromosome:
- 3p26.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-18
- Date modifiied:
- 2016-10-11
- Gene:
- LRR1 NIH gene
- Name:
- leucine rich repeat protein 1
- Previous symbol:
- PPIL5
- Synonyms:
- MGC20689, LRR-1
- Chromosome:
- 14q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-20
- Date modifiied:
- 2014-11-18
Related products to: Human IL-5 ELISA kit
Related articles to: Human IL-5 ELISA kit
- Allergic asthma (AA) is a consequential global health challenge immunologically characterized by type 2 inflammatory responses and no definite treatment, demanding novel therapeutic strategies. Eosinophils are the main orchestration of AA, whose recruitment and activation depends on C-C chemokine receptor type 3 (CCR3). Genetically engineered stem cells present enhanced therapeutic efficacy and a compelling strategy to control diseases. Therefore, this study was conducted to investigate the effects of a CCR3 antagonist and genetically engineered mesenchymal stem cells (MSCs) on AA progression in mice models. MSCs were isolated from bone marrow and transduced by SP-A and RGDS genes. Mice with induced AA were treated with the CCR3 antagonist and modified MSCs, and then pathologic features, including AHR, percentage of eosinophil in BALF, levels of SOD and CAT (oxidative stress biomarkers), total and OVA-specific IgE, IL-4, IL-5, IL-13, and IL-33, as well as histopathology of the lung for peribronchial and perivascular inflammation, hyperplasia of the goblet cells, and overproduction of mucus were assessed. SP-A and RGDS transduced MSCs combined with the CCR3 antagonist effectively reverted AHR, eosinophil infiltration into BALF, elevation of IgE and Th2 cytokines, and histopathological derangements associated with AA, along with enhanced activity of CAT and SOD. Altogether, genetically modified MSCs in combination with a CCR3 antagonist could control AA progression biomarkers. - Source: PubMed
Publication date: 2026/10/02
Zhu MingSun Yunqing - The role of inflammatory cytokines in the prognosis of colorectal cancer (CRC) has been evaluated. However, the impact of perioperative changes on prognosis has not yet been evaluated. The aim was to investigate the correlation between postoperative-to-preoperative ratios of inflammatory cytokines and cancer‑specific survival (CSS) rates in patients with CRC who underwent curative resection. In this retrospective cohort study, patients with CRC who underwent radical resection between September 2019 and December 2020 were analyzed. The effects of the postoperative-to-preoperative ratios of inflammatory cytokines (including IFN-α, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17, and TNF-α) and six other clinical factors on cancer‑specific survival were assessed through univariate and multivariate Cox regression analyses. Survival curves were generated via Kaplan-Meier analysis. A total of 153 CRC patients who underwent radical resection were included in this study. Univariate analysis revealed that age (hazard ratio (HR) = 1.05, p = 0.031), tumor stage (HR = 3.61, p < 0.001), and the IL-1β ratio (HR = 1.00, p = 0.012) were significant prognostic factors. Multivariate analysis indicated that both the IL-1β ratio (adjusted HR = 1.05, p = 0.037) and tumor stage (adjusted HR = 3.83, p < 0.001) remained independent prognostic factors. Kaplan-Meier analysis confirmed the significant association between a high IL-1β ratio and poorer cancer‑specific survival. The postoperative-to-preoperative IL-1β ratio may serve as a potential prognostic biomarker for patients with CRC following radical resection, with higher ratios indicating poorer cancer‑specific survival; however, these exploratory findings require validation in prospective cohorts with standardized sampling protocols. - Source: PubMed
Publication date: 2026/10/01
Gao DonghuiZhang JieZeng ZongyueChen ZhenzhouAo HangWu XingyeZeng Li - - Source: PubMed
Publication date: 2026/10/01
Yun JamesRichardson RobynHissaria PravinKatelaris ConstanceTrubiano JasonZubrinich CeliaTong Winnie W YCarr Andrew - Fatigue-like impairment after cancer surgery occurs within a complex treatment context, yet experimental preparations that incorporate tumor history, resection, and postoperative treatment remain limited. This study characterized a composite fatigue-like phenotype after subcutaneous Lewis lung carcinoma (LLC) resection followed by low-dose cisplatin. Male C57BL/6J mice were assigned to Blank, Sham, Surgery, and Model groups (n=10/group). The Surgery group underwent LLC inoculation, complete tumor resection, and postoperative saline, whereas the Model group underwent the same procedures followed by cisplatin (2 mg/kg on postoperative days 1 and 4). Body weight, grip strength, treadmill performance, open-field activity, and hepatic and skeletal muscle glycogen were assessed. Serum IL-5, IL-6, IL-10, and TNF-α were explored in three randomly selected mice per group and in an exploratory clinical cohort comprising 5 postoperative patients with lung cancer and 5 control participants. The Model group exhibited a broader multidomain impairment than the Surgery group, characterized by greater postoperative body-weight loss, reduced motor performance and exercise endurance, altered spontaneous locomotor behavior, and reduced peripheral glycogen stores. In the three mice sampled per group, Model mice also showed higher IL-5 and IL-6 concentrations, lower TNF-α concentrations, and similar IL-10 concentrations. In the human cohort, IL-6 showed higher concentrations in postoperative patients than in controls, directionally consistent with the mouse findings, whereas IL-5 and IL-10 did not show a consistent cross-species pattern. Thus, LLC resection followed by low-dose cisplatin was associated with a multidomain fatigue-like functional phenotype. - Source: PubMed
Publication date: 2026/10/01
Wu TongtongZhang YutongYuan ZichunKuo Chia-HuaChoudhary Muhammad IqbalYang GuowangZhang Ganlin - Familial Mediterranean fever (FMF), an autoinflammatory disease caused by MEFV mutations, frequently coexists with immune-mediated conditions such as spondyloarthritis (SpA). However, the contribution of innate lymphoid cells (ILCs) to FMF-associated SpA remains poorly defined. Our objective was to characterize the phenotype and functional activity of ILCs in pediatric patients with FMF, SpA, and overlap FMF/SpA. Peripheral blood mononuclear cells (PBMCs) and synovial fluid mononuclear cells (SFMCs) from FMF (n = 15), SpA (n = 11), FMF/SpA (n = 13), and age-matched healthy controls (n = 14) were analyzed by flow cytometry to quantify ILC subsets. Plasma and synovial cytokines were measured by ELISA, and expression of ILC-associated cytokines in PBMCs and sorted ILCs was assessed by quantitative PCR. Total ILC frequencies and subset distributions in PBMCs and SFMCs were comparable across groups (p > 0.05). However, FMF/SpA patients demonstrated increased IL4 and IL5 expression in sorted ILCs (p < 0.05), consistent with a type 2-skewed ILC activation profile. PBMC thymic stromal lymphopoietin (TSLP) expression was elevated in SpA (p < 0.01). Plasma IL-6, IL-8 and IP-10 concentrations were higher in the full cohort of FMF/SpA patients; however, these differences were sensitive to outlier exclusion and indicate substantial inter-individual heterogeneity. Synovial fluid from SpA patients showed higher IP-10 and IL-17 levels (p < 0.05). Pediatric FMF/SpA is characterized by altered ILC functional polarization rather than numerical expansion, with a prominent type 2 ILC signature. In contrast, SpA displays synovial IP-10 and IL-17 enrichment and increased PBMC TSLP expression. These findings suggest distinct innate immune activation axes in overlap versus isolated SpA and support further investigation of ILC-mediated pathways in FMF-associated spondyloarthritis in larger cohorts. - Source: PubMed
Publication date: 2026/07/23
Kisaarslan Aysenur PacAzizoglu Zehra BusraCicek Sumeyra OzdemirDemir Busra SenizPoyrazoglu HakanEken Ahmet