Human Emmprin CD147 ELISA kit
- Known as:
- Human Emmprin CD147 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- LF-EK50719
- Product Quantity:
- 1
- Category:
- Elisa Kits
- Supplier:
- Abfron
- Gene target:
- Human Emmprin CD147 ELISA kit
Related genes to: Human Emmprin CD147 ELISA kit
- Gene:
- BSG NIH gene
- Name:
- basigin (Ok blood group)
- Previous symbol:
- OK
- Synonyms:
- EMMPRIN, CD147, EMPRIN
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-25
- Date modifiied:
- 2019-04-23
Related products to: Human Emmprin CD147 ELISA kit
Related articles to: Human Emmprin CD147 ELISA kit
- : Congenital pulmonary airway malformation (CPAM) is a rare developmental disorder characterized by cystic lung lesions, yet its extracellular matrix (ECM) composition remains poorly understood. This study employed decellularization and data-independent acquisition (DIA) proteomics to compare ECM profiles between cystic (CPAM) and histologically normal non-diseased (ND) regions from the lungs of four patients. : The decellularized scaffolds retained their native architecture with minimal residual DNA (<50 ng/mg). Proteomic analysis revealed 431 differentially expressed proteins (DEPs), with 171 upregulated and 260 downregulated in CPAM. Key findings revealed CPAM-specific enrichment of collagens (COL4A6, COL4A2, COL10A1, COL21A1 and PIIINP), glycoproteins (SPP1, FRAS1, FREM1, FREM2, LTBP1 and FBLN7), ECM regulators (TENM2, ROR2 and OMD), and ECM-affiliated proteins (ANXA7), alongside downregulation of glycoproteins (VASN and ABI3BP), proteoglycans (PODN and MXRA7), ECM regulators (SCARA5, PAPPA, SAA4, CPXM1, CTSC, THY1, SERPINA6/A1/D1, BSG, LYVE1, ITIH4 and CD44), and ECM-affiliated proteins (LGALSL). Pathway analysis highlighted the dysregulation of TGF-β, PI3K-AKT, and mTOR signaling in CPAM and aberrant ECM-cell interactions in pathogenesis. We also evaluated their functional properties and investigated the impact of ECM-based hydrogels on recellularization. : These findings provide a comprehensive proteomic atlas of CPAM ECM alterations, offering insights into disease mechanisms and potential therapeutic targets. - Source: PubMed
Publication date: 2026/08/30
Li YananYang PingYuan MiaoZhu XinglongMao ShengqiangYang YingYao MenglinChen FeiZhou YanyanBao JiXu ChangLi Yi - The recyclability of pots made entirely from brewer's grains (BSGs) and poly(butylene succinate) (PBS) at a PBS/BSG weight ratio of 70:30, hereafter referred to as MIXr, was evaluated. The resulting pots exhibited tensile strength at break comparable to that of conventional fossil-based polymeric materials. The study aimed to determine the maximum content of recycled materials that could be incorporated into virgin (PBSv) while maintaining acceptable properties, thereby extending the material's life cycle through mechanical recycling before disposal via biodegradation or composting. For comparison, blends of virgin PBS with recycled PBS (PBSv-PBSr) and recycled BSG/PBS material (PBSv-MIXr) were prepared at the same recycled-material contents. The materials were characterized in terms of processability, tensile properties, thermal stability (TGA), chemical group analysis (FTIR), and surface properties. The results showed that the presence of BSG significantly influences the recyclability of the biocomposite. While virgin PBS could incorporate up to 10 wt.% recycled PBS without a significant loss in ductility or thermal stability, PBSv-MIXr blends exhibit a ~20-30% reduction in deformability at MIXr contents ranging from 2 wt.% to 20 wt.% and a reduction in thermal stability ranging from 16-22% at levels of incorporation ranging between 10 wt.% and 40 wt.%. - Source: PubMed
Publication date: 2026/08/31
Visco AnnamariaSindona GianmarcoScolaro CristinaBrahimi Salim - Colorectal cancer (CRC) exhibits marked cellular heterogeneity, and the cellular context of malignancy-associated epithelial programs remains incompletely defined. - Source: PubMed
Publication date: 2026/08/31
Tang WeichunXu PengchenWang ShengliSu GuizhenLi QiangGu BiaoWang Nannan - Education systems need to withstand frequent shocks, including disease and climate events, which close schools for more than 222 million children. During these emergencies, alternative models are needed to deliver education. However, rigorous evaluation of effective educational approaches in these settings is challenging and rare, especially across multiple countries. Here we present results from five randomized trials in India, Kenya, Nepal, the Philippines and Uganda to evaluate the provision of education in emergency settings. We test multiple scalable models of remote targeted tutoring instruction, comparing delivery by governments and non-governmental organizations (NGOs). Whereas text messages have mixed results, tutorials conducted via phone call show effectiveness across diverse settings. We find large and robust effect sizes on learning. These effects are highly cost-effective, and deliver approximately 4 years of high-quality instruction per US$100 spent. Results show large effects when delivered by government teachers or NGO instructors. Together, our results reveal that it is possible to strengthen the resilience of education systems, enabling education provision amid disruptions, and to deliver cost-effective learning gains across contexts and with governments. - Source: PubMed
Publication date: 2026/09/09
Angrist NoamAinomugisha MichealBathena Sai PramodBergman PeterCrossley ColinCullen ClaireLetsomo ThatoMatsheng MoitshepiPanti Rene MarlonSabarwal ShwetlenaSullivan Tim - Emerging evidence implicates insomnia as a potential risk factor in carcinogenesis, potentially involving systemic inflammation, circadian disruption, and microbiome alterations. However, the molecular associations linking insomnia-related features to colorectal cancer (CRC), particularly with respect to tumor biology, immune microenvironmental states, and therapy-relevant phenotypes, remain largely unexplored. Multi-omics integration of genomic, transcriptomic, and microbiome data from 3,026 CRC patients across seven independent cohorts, including a large, well-annotated Clinical Omics study of Colorectal Cancer in China (COCC) cohort, enabled insomnia-based molecular classification through unsupervised non-negative matrix factorization (NMF) clustering. The insomnia subtype (IS) was biologically characterized via pathway enrichment, immune deconvolution, microbial profiling, and single-cell transcriptomics. Furthermore, an insomnia score (ISscore) was developed and validated in multiple cohorts for risk stratification and assessment of treatment-response-related indicators in CRC. Unsupervised clustering revealed two distinct molecular subtypes (IS1/IS2), with IS2 demonstrating significantly poorer survival. IS2 exhibited marked activation of EMT/angiogenesis pathways versus cell cycle activation in IS1. The IS2 microenvironment showed increased immunosuppression-related infiltration and exhausted T cell signatures, together with intratumoral microbiome variation characterized by depletion of Ruminococcaceae UCG-002 and enrichment of Hungatella/Selenomonas. The ISscore system stratified survival risk and was associated with computational indicators of immunotherapy response. Single-cell analysis nominated PPIA-BSG as a potential cell-cell communication signal involving high-ISscore tumor cells, CXCL12+ endothelial cells, and CLEC9A+ dendritic cell subsets. This multi-omics characterization of insomnia-CRC interplay suggests that insomnia-related molecular features are associated with an immunologically distinct and microbiome-altered tumor ecosystem. The ISscore provides a reproducible framework for capturing insomnia-related molecular heterogeneity, supporting risk stratification and future evaluation of therapy-relevant phenotypes.IMPORTANCEChronic insomnia affects millions, but it is not typically considered a cancer risk factor. Our study, analyzing vast biological data from over 3,000 colorectal cancer patients, uncovers a potential link between a person's predisposition to insomnia and their risk of developing this disease. This suggests that the biological pathways related to sleep may play a role in cancer development. Understanding this connection opens up new avenues for identifying individuals at higher risk and developing novel prevention strategies for colorectal cancer. - Source: PubMed
Publication date: 2026/09/09
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