Human CCL17 TARC ELISA kit
- Known as:
- Human CCL17 TARC Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- LF-EK50707
- Product Quantity:
- 1
- Category:
- Elisa Kits
- Supplier:
- Abfron
- Gene target:
- Human CCL17 TARC ELISA kit
Related genes to: Human CCL17 TARC ELISA kit
- Gene:
- CCL17 NIH gene
- Name:
- C-C motif chemokine ligand 17
- Previous symbol:
- SCYA17
- Synonyms:
- TARC, ABCD-2
- Chromosome:
- 16q21
- Locus Type:
- gene with protein product
- Date approved:
- 1996-10-26
- Date modifiied:
- 2016-10-05
Related products to: Human CCL17 TARC ELISA kit
Related articles to: Human CCL17 TARC ELISA kit
- T cells are often enriched at barrier tissues, yet little is known of their roles in barrier sensing and relevance to associated disease. CD1a is a Major Histocompatibility Complex class I-like molecule expressed by Langerhans cells, which forms complexes with lipid antigens to facilitate recognition by non-classical CD1a-reactive T cells. - Source: PubMed
Publication date: 2026/09/08
Ottakandathil Babu RosanaNahler JaninaDooley KylaNaidoo KarmellaKobiela AdrianNg Soo WeeiYe John HBridges EstherAgarwal DevikaSimmons AlisonKoohy HashemAntanaviciute AgneAdams AnnaKiourlappou MariaTodd PeterTaylor StephenMonast CalixteCuff CarolynMarsden Brian DBuckley Christopher DDatta Sandip KFreeman ThomasDendrou CalliopeUhlig HolmLeung Monica W LPolak MartaChen Yi-LingOgg Graham - Atopic dermatitis (AD) in children differs immunologically and in barrier characteristics from adult AD, yet current severity assessment still relies heavily on clinical scoring systems with inherent subjectivity. This review summarizes advances in biomarkers associated with disease severity and persistence, as well as non-invasive detection techniques and targeted therapies. TARC/CCL17, periostin, total IgE, and eosinophil counts show consistent utility in grading severity, whereas FLG loss-of-function mutations, VEGF, S100A8/A9, and early skin barrier indicators are promising predictors of disease persistence and atopic march progression. Tape stripping and sebum RNA analysis enable safe, repeated monitoring in children. Despite these advances, most biomarkers still lack pediatric-specific cut-offs and large-scale validation. Future efforts should focus on establishing multi-marker panels, pediatric reference intervals, and machine learning models for endotype classification. Incorporating these tools into routine practice would facilitate early risk stratification, precise targeted treatment selection, and ultimately more personalized management of pediatric AD. - Source: PubMed
Publication date: 2026/08/18
Li ZhuoyuanLi Yuanjun - Kawasaki disease is an acute systemic vasculitis, and the clinical significance of serum thymus and activation-regulated chemokine (TARC) remains incompletely understood. We examined whether pre-treatment age-adjusted serum TARC was associated with inflammation-based intravenous immunoglobulin (IVIG) resistance risk stratification. - Source: PubMed
Tomori ShinyaTakahashi KazuhiroKoyama TakayukiMimaki Masakazu - Although most upper respiratory tract infections (URTIs) have a viral etiology, antibiotics are widely prescribed, thus contributing substantially to antimicrobial resistance. This study investigated the potential beneficial effects of a novel strain, LMG P-27481, against major URT pathobionts (, , , , and ) with the aim of reducing or delaying antibiotic use. Antibacterial and immunomodulatory activities were evaluated using alone or combined with resveratrol, a natural compound with antiviral and anti-inflammatory properties. Both agents inhibited pathogen growth, while their combination showed additive antibacterial activity, particularly against Gram-negative bacteria. Antioxidant assays demonstrated significant antioxidant capacity for both agents, with enhanced effects in combination in NBT and ABTS assays but antagonistic in ORAC. Immune mediators (IL-6, IL-8, IL-1β, TNF-α, IL-25, IL-33, CCL17, CCL22) were assessed in epidermal, epithelial, and macrophage cell lines, together with epidermal integrity markers (Filaggrin, Loricrin, Involucrin) in a 3D reconstructed human skin model (EpiDermFT). , resveratrol, and their combination exerted cell-specific effects in the different models, modulating cytokine expression and production, and barrier integrity. Our findings support the potential efficacy of oral LMG P-27481 plus resveratrol in URTIs. - Source: PubMed
Publication date: 2026/08/12
Mattioli RobertoDi Risola DanielSivori FrancescaFranzese OrnellaGenovese IlariaMastromarino PaolaMosca Luciana - : Atopic dermatitis (AD) is a persistent and recurring skin disease characterized by epidermal barrier dysfunction, immune dysregulation, and elevated expression of proinflammatory mediators. We investigated the anti-inflammatory potential of polynucleotides (PN), highly purified DNA biopolymers isolated from salmonid gonads, in keratinocyte and macrophage activation models. : RAW 264.7 macrophages were stimulated with lipopolysaccharide (LPS), whereas HaCaT keratinocytes were stimulated with tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). The effects of PN treatment on the production or expression of inflammatory mediators, cytokines, and chemokines were evaluated. Changes in the phosphorylation of mitogen-activated protein kinases (MAPKs) and Janus kinase 1/signal transducer and activator of transcription 3 (JAK1/STAT3) and in the nuclear localization of nuclear factor-κB (NF-κB) were also assessed. : In LPS-activated RAW 264.7 macrophages, PN treatment significantly suppressed nitric oxide production and downregulated the expression of inducible nitric oxide synthase (iNOS), TNF-α, IL-1β, and IL-8, accompanied by reduced NF-κB nuclear translocation. In TNF-α/IFN-γ-stimulated HaCaT keratinocytes, PN treatment markedly decreased the secretion levels of IL-6, IL-1β, and thymic stromal lymphopoietin. Moreover, PN treatment markedly reduced T-cell-recruiting chemokines, including MDC/CCL22, TARC/CCL17, RANTES/CCL5, and IL-8. Signaling analyses demonstrated that PN treatment attenuated the phosphorylation of key MAPKs (ERK, JNK, and p38) and the JAK1/STAT3 axis. Furthermore, PN treatment markedly reduced NF-κB nuclear translocation. : These in vitro findings indicate that the anti-inflammatory effects of PN are associated with reduced activation of multiple core signaling pathways governing cytokine and chemokine responses, supporting further investigation of PN in AD and other chronic inflammatory skin diseases. - Source: PubMed
Publication date: 2026/08/13
Ha Ye JinTak Ka HeeLee Jong LyulKim Chan WookMoon Ik JunYoon Yong Sik