CymaxTM Mouse IL-6 ELISA Kit
- Known as:
- CymaxTM Mouse Interleukin-6 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- LF-EK0270
- Product Quantity:
- 1
- Category:
- Elisa Kits
- Supplier:
- Abfron
- Gene target:
- CymaxTM Mouse IL-6 ELISA Kit
Related genes to: CymaxTM Mouse IL-6 ELISA Kit
- Gene:
- CEBPB NIH gene
- Name:
- CCAAT enhancer binding protein beta
- Previous symbol:
- TCF5
- Synonyms:
- LAP, CRP2, NFIL6, IL6DBP, C/EBP-beta
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1991-02-27
- Date modifiied:
- 2018-02-23
- Gene:
- CEBPD NIH gene
- Name:
- CCAAT enhancer binding protein delta
- Previous symbol:
- -
- Synonyms:
- CRP3, CELF, C/EBP-delta, NF-IL6-beta
- Chromosome:
- 8q11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-24
- Date modifiied:
- 2018-02-23
- Gene:
- ENTPD6 NIH gene
- Name:
- ectonucleoside triphosphate diphosphohydrolase 6
- Previous symbol:
- CD39L2, IL6ST2
- Synonyms:
- NTPDase-6, dJ738P15.3
- Chromosome:
- 20p11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-20
- Date modifiied:
- 2019-02-28
- Gene:
- IL6 NIH gene
- Name:
- interleukin 6
- Previous symbol:
- IFNB2
- Synonyms:
- IL-6, BSF2, HGF, HSF
- Chromosome:
- 7p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2017-07-12
- Gene:
- IL6RP1 NIH gene
- Name:
- interleukin 6 receptor pseudogene 1
- Previous symbol:
- IL6RL1
- Synonyms:
- -
- Chromosome:
- 9q22.2
- Locus Type:
- pseudogene
- Date approved:
- 1991-08-18
- Date modifiied:
- 2014-11-19
Related products to: CymaxTM Mouse IL-6 ELISA Kit
Related articles to: CymaxTM Mouse IL-6 ELISA Kit
- To reduce the adverse effects of high-carbohydrate diets (HC diets), this study aimed to investigate the mechanisms of the regulatory effects of supplementation of the HC diets with the snakehead homolog Lactococcus lactis L19 (L. lactis L19) on growth performance, oxidative stress, inflammation, glucose and lipid metabolism, and apoptosis in Channa argus (C. argus). A total of 270 fish were divided into control (CON), HC, and HC supplemented with 1 × 10 CFU/g L. lactis L19 (HL19) groups and fed for 8 weeks. Results showed that L19 enhanced growth performance and insulin secretion while reducing blood glucose and blood lipids. Liver H&E and PAS staining showed that supplementation with L19 ameliorated HC diet-induced liver damage and glycogen accumulation. Simultaneously, L19 promoted glycolysis and gluconeogenesis enzyme activities and gene expression, inhibited ACC and FAS, and promoted CPT1 and HSL; L19 also reduced the content of oxidative stress parameters and increased the activities of antioxidant enzymes and related gene expression levels (nrf2, ho-1, and nqo-1), thereby alleviating oxidative stress; furthermore, L19 enhanced serum immunological parameters and mitigated inflammation and apoptosis by upregulating anti-inflammatory factors (tgf-β, il-10, iκbα, and il-1β), anti-apoptotic gene bcl2, and heat shock proteins (hsp70 and hsp90) and downregulating the expressions of pro-inflammatory factors (nf-κb, tnf-α, il-8, and il-6) and pro-apoptotic genes (cas3, cas8, cas9, and bax). In conclusion, L19 supplementation enhanced the growth performance in C. argus by activating the IR/PI3K/AKT pathway, thereby ameliorating the glucose and lipid metabolism disorders induced by HC diets, effectively alleviating oxidative stress, inhibiting inflammation, and preventing apoptosis. - Source: PubMed
Publication date: 2026/05/26
Guo XiaXu JieFang QiongyaZhang XinyuZhang PingShen ZhiqiangJiao SiqiKong YidiLi MinWang Guiqin - Psoriasis is a chronic autoimmune skin disorder marked by rapid skin cell proliferation, causing red, scaly patches. Current treatments often show limited efficacy and adverse effects. The family Apiaceae is traditionally valued for its medicinal uses, particularly anti-inflammatory effects, and among its members are Deverra tortuosa (Desf.) DC. (D. tortuosa) and Deverra triradiata Hochst. ex Bioss. (D. triradiata) with recognized therapeutic value. As nanotechnology-based formulations enhance skin penetration and therapeutic efficacy, this study investigated the antipsoriatic activity of plant-based nanocreams (NCs). Phenolic content of D. tortuosa and D. triradiata aerial parts was analyzed by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Nanoparticles were prepared with droplet sizes of 300-470 nm and a positive surface charge. Mice were divided into five groups: control (cream base), imiquimod (IMQU; 62.5 mg/day for 7 days), a commonly used inducer of psoriasis-like dermatitis, standard (tacrolimus 20 mg/kg/day, 2 h after IMQU), IMQU + D. triradiata NC (2% once daily, 2 h after IMQU), and IMQU + D. tortuosa NC (2% once daily, 2 h after IMQU). D. tortuosa and D. triradiata NCs significantly alleviated IMQU-induced systemic and skin-related psoriatic changes in mice by reducing spleen index, inflammatory cytokines, including interleukin-17 (IL-17), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), as well as nuclear factor kappa-B (NF-κB), signal transducer and activator of transcription-3 (STAT3), and Ki-67 expression. Histological analysis confirmed marked restoration of normal skin architecture, with D. tortuosa showing the highest therapeutic efficacy. These findings suggest that D. tortuosa and D. triradiata NCs possess promising anti-psoriatic potential, through immunomodulatory and anti-inflammatory mechanisms, with D. tortuosa demonstrating superior efficacy. They may serve as effective natural alternatives to conventional psoriasis treatments. - Source: PubMed
Publication date: 2026/05/26
Kamel Reem AAhmed Asmaa ATeiama Mohammed SElgayed Sabah HKhattab Mohamed AIbrahim Magda TAbouelenein DoaaCaprioli GiovanniMustafa Ahmed MEl-Sayed Elsayed KMoharram Fatma A - This study aims to investigate the role of AU-rich element RNA-binding factor 1 (AUF1) in regulating inflammatory responses and senescence processes within auditory hair cells. - Source: PubMed
Publication date: 2026/05/26
Li LihuaXiao YunLiu XingruiHe JinyingWu WenjingCai DianChen Xubo - Syringaldehyde (SG) is a naturally derived phenolic aldehyde known for a range of biological activities. This study evaluated its protective potential against the chemically induced gastric injury model and investigated the underlying mechanisms involved. Acute gastric ulceration was induced in male Swiss albino mice by intragastric administration of a mixture of 0.3 M HCl and 70% ethanol. SG was orally administered at 25 and 50 mg/kg, and omeprazole (20 mg/kg) served as the reference anti-ulcer drug. HCl/ethanol exposure caused severe gastric mucosal injury characterized by increased lipid peroxidation, elevated levels of inflammatory mediators (IL-6, NFκB, iNOS, Cox-2, TNF-α, and IL-1β), and enhanced pro-apoptotic markers Bax and Cas-3. In parallel, antioxidant defense mechanisms were markedly impaired, as indicated by decreased GSH levels, reduced SOD and CAT activities, diminished mucosal protective mediators (PGE2 and NO), and downregulation of HO-1, Nrf2, and Bcl-2 expression. Treatment with SG significantly attenuated oxidative stress, gastric mucosal damage, and inflammatory responses, and modulated apoptosis-related markers. These protective effects were accompanied by restoration of antioxidant enzyme activities and increased levels of PGE2 and NO, together with upregulation of Nrf2/HO-1 expression. Overall, these results suggest that SG may exert gastroprotective effects against gastric injury through modulation of oxidative stress, inflammation, and apoptotic pathways. - Source: PubMed
Publication date: 2026/05/26
Yalinbas-Kaya BerrinCesur SelcanInce Sinan - Atherosclerosis is a chronic inflammatory vascular disease characterized by endothelial activation and progressive thickening of the tunica intima. This study aimed to evaluate the effects of combined Clitoria ternatea and Moringa oleifera (CT-MO) extracts, designated as CT-MO, on endothelial activation markers and tunica intima thickness in male Wistar rats fed a high-fat and high-cholesterol (HFHC) diet. Phytochemical screening and ultraviolet-visible (UV-Vis) spectrophotometry were conducted to determine the optimal extract formulation, which was subsequently administered in vivo at doses of 200, 400, and 600 mg/kg body weight for 45 days. Serum levels of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6), and cluster of differentiation 40 (CD40) were measured using enzyme-linked immunosorbent assay (ELISA), while tunica intima thickness was assessed histologically. Correlation and exploratory multivariate regression analyses were conducted to evaluate associations between inflammatory biomarkers and vascular structural remodeling. The CT-MO (25:75) combination demonstrated the highest flavonoid content (79.10 mg/g). The HFHC diet significantly increased inflammatory biomarkers and tunica intima thickness (12.22 µm). Treatment with CT-MO extract significantly reduced VCAM-1, ICAM-1, IL-6, and CD40 levels in a dose-dependent manner (p < 0.05). Correlation analysis demonstrated significant positive associations between inflammatory biomarkers and tunica intima thickness, while exploratory multivariate analysis identified VCAM-1 as the biomarker most strongly associated with vascular structural remodeling. The highest dose (600 mg/kg) exhibited the most pronounced effect, with biomarker levels not significantly different from healthy controls and tunica intima thickness reduced to 3.42 µm. These findings suggest that the combined CT-MO extract may attenuate endothelial activation and vascular structural remodeling associated with early atherosclerosis. - Source: PubMed
Publication date: 2026/05/26
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