CymaxTM Mouse IL-5 ELISA Kit
- Known as:
- CymaxTM Mouse Interleukin-5 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- LF-EK0269
- Product Quantity:
- 1
- Category:
- Elisa Kits
- Supplier:
- Abfron
- Gene target:
- CymaxTM Mouse IL-5 ELISA Kit
Related genes to: CymaxTM Mouse IL-5 ELISA Kit
- Gene:
- CSF2RB NIH gene
- Name:
- colony stimulating factor 2 receptor beta common subunit
- Previous symbol:
- IL3RB
- Synonyms:
- IL5RB, CD131, betaGMR
- Chromosome:
- 22q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-07
- Date modifiied:
- 2017-07-12
- Gene:
- IL5 NIH gene
- Name:
- interleukin 5
- Previous symbol:
- -
- Synonyms:
- IL-5, EDF, TRF
- Chromosome:
- 5q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2015-07-06
- Gene:
- IL5RA NIH gene
- Name:
- interleukin 5 receptor subunit alpha
- Previous symbol:
- IL5R
- Synonyms:
- CDw125, CD125
- Chromosome:
- 3p26.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-18
- Date modifiied:
- 2016-10-11
- Gene:
- LRR1 NIH gene
- Name:
- leucine rich repeat protein 1
- Previous symbol:
- PPIL5
- Synonyms:
- MGC20689, LRR-1
- Chromosome:
- 14q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-20
- Date modifiied:
- 2014-11-18
Related products to: CymaxTM Mouse IL-5 ELISA Kit
Related articles to: CymaxTM Mouse IL-5 ELISA Kit
- Allergic rhinitis is a chronic non-communicable disease that adversely affects respiratory health and quality of life. Ginger-based formulations, owing to their anti-inflammatory and immunomodulatory properties, may offer a promising alternative therapeutic option. - Source: PubMed
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Inpan RatchanonKantasa TattiyaHanprasertpong NutthiyaNa Takuathung MingkwanKoonrungsesomboon Nut - Ziziphus spina-christi is a medicinal plant native to arid regions of the UAE and has been used in folk medicine to treat respiratory diseases, but its efficacy in asthma triggered by allergens remains to be confirmed. - Source: PubMed
Publication date: 2026/05/22
Sharif-Askari Narjes SahebShakartalla Sarra BMdkhana BushraIsmail AsmaaEladham Mariam WedAl-Sheakly Baraa Khalid SalahMousa MouathAl-Hroub Hamza MAlmoalla Aseela AbdullaAl Hmoudi Maryam Ali Saeed MohamedAlhmoudi Ahmed Mohamed Saeed AliSharif-Askari Fatemeh SahebTsombou Francois MitterandSemreen Mohammad HLamghari FouadHalwani Rabih - Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections and poses a serious threat to young children, older adults, and immunocompromised individuals. We previously designed a pre-fusion stabilized F protein (pre-F), TriM-5, using a dynamic regulation mechanism, and produced a recombinant protein-based vaccine candidate that exhibited potent protection against RSV. However, several studies have revealed that the stabilization of pre-F achieved in protein form may not be sufficient for application in mRNA vaccine development. Here, based on TriM-5, we designed an mRNA vaccine candidate to assess whether the dynamic regulation-based stabilizing mutations of TriM-5 are also effective in an mRNA format. The TriM-5 mRNA was codon-optimized using in-house software named NVSI_GAmRNAopt, which employed a genetic algorithm incorporating multiple empirical parameters for coding sequence (CDS) optimization, and encapsulated using lipid nanoparticles (LNPs). Mouse immunization showed that after CDS optimization, the IgG antibody titers increased approximately threefold, indicating the effectiveness of our codon-optimization algorithm. Compared with the Moderna RSV mRNA sequence encapsulated with our proprietary BM028 LNPs, the TriM-5 mRNA-LNP induced 3.03-fold higher neutralizing antibody titers against RSV A2 virus, along with significantly higher IFN-γ, IL-5 and IL-17A secretion levels, indicating its superior immunogenicity. Virus challenge experiments demonstrated that both TriM-5 mRNA-LNP and Moderna mRNA-LNP reduced lung viral loads effectively, with no obvious lung pathology. The designed TriM-5 mRNA-LNP exhibits good immunogenicity and protective efficacy, and thereby may serve as a promising candidate for further vaccine development. - Source: PubMed
Publication date: 2026/05/20
Shao ShuaiDong Ze YuanKang Zi YaoZhang HaoZheng XiangShen Fu JieJin Yu QinPan ZhengLi XinLiu NingLi Xin GeLiu Zhao MingZhang Xue FengRen JinHan Zi BoLiang YuZhang JingSu Ji GuoLi Qi Ming - Cryptococcosis is a systemic fungal infection caused by Cryptococcus species, predominantly Cryptococcus neoformans. The disease affects the lungs and can disseminate to the Central Nervous System (CNS), leading to high-mortality meningoencephalitis. Purinergic signaling, driven by extracellular nucleotides and nucleosides, plays a key role in immune regulation. Among purinergic receptors, P2X7 receptors modulate immune cell activity and cytokine release. However, its role in cryptococcosis remains unclear. Here, we evaluated the effects of Brilliant Blue G (BBG, 50 mg/kg), a widely used pharmacological inhibitor of P2X7 receptor, in a murine model of cryptococcosis. Infection increased pulmonary expression of P2X7, P2Y, and P2Y receptors while reducing A receptor levels. Although BBG treatment improved lung mechanics and reduced pulmonary inflammation at 7 days post-infection, it paradoxically resulted in increased mortality. Lung cytokine profiling revealed decreased expression of pro-inflammatory mediators (IL-1β, TNF-α, and IFN-γ), along with elevated levels of IL-10, TGF-β, IL-5, and IL-13, and increased expression of the transcription factors GATA3 and Foxp3, suggesting an association with a Th2/Treg-like immune profile. While pulmonary fungal burden remained unchanged, BBG treatment facilitated fungal dissemination to the brain, accompanied by increased glial activation. These findings suggest that BBG administration is associated with reduced lung inflammation, along with impaired systemic host responses and increased CNS dissemination, highlighting that pulmonary immune responses may influence disease progression and dissemination to distal tissues. Our data support the involvement of purinergic signaling in the control of fungal dissemination to the brain, with effects consistent with P2X7 blockade. - Source: PubMed
Publication date: 2026/05/22
Braga Igor Correa da CostaAlves ViníciusAraujo Glauber Ribeiro de SousaCrepaldi Letícia DinizOliveira-Cruz Lorraineda Silva Milla Souza Pessoade Souza Serra Sabrina SodréCristina-Rodrigues FabianaAlves Vinícius SantosCoutinho-Silva RobsonFrases SusanaCruz Fernanda FerreiraMorales Marcelo MarcosSavio Luiz Eduardo Baggio - To investigate the risk factors for severe influenza A virus (IAV) infection in children and construct a nomogram prediction model based on these factors. A retrospective analysis was conducted on the clinical data of 178 children with IAV infection admitted to the Third Affiliated Hospital of Zhengzhou University between January and February 2025. According to disease severity, patients were divided into a mild group (n = 123) and a severe group (n = 55). The severe group was further stratified into a pneumonia subgroup (n = 25) and a non-pneumonia subgroup (n = 30) based on the presence of pneumonia. General clinical characteristics were compared between the mild and severe groups. Variables identified through univariate analysis were entered into multivariate logistic regression to determine independent risk factors for severe IAV infection. A nomogram model was subsequently established, and its performance was evaluated and validated using calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA). Compared with the mild group, children in the severe group were older, had longer hospital stays and prolonged fever duration, and had higher incidences of pneumonia and mental status abnormalities (all P < 0.05). Regarding immune inflammatory indicators, neutrophil percentage, Interleukin-2 (IL-2), tumor necrosis factor-alpha (TNF-α), IL-5, IL-12P70, and immunoglobulin G (IgG) and IgA levels were significantly higher in the severe group than in the mild group (all P < 0.05), whereas Interferon-alpha (IFN-α) levels were significantly lower (P < 0.05). Multivariate logistic regression analysis demonstrated that elevated IL-2 and TNF-α levels, prolonged fever duration, and mental status abnormalities were independently associated with severe IAV infection (all P < 0.05). The calibration curve, ROC curve, and DCA indicated that the nomogram model had good predictive Value and clinical utility. The multidimensional nomogram constructed by integrating IL-2, TNF-α, and fever duration and mental status abnormalities demonstrates high predictive value and clinical utility in forecasting severe IAV infection. This model aids in the early identification of severe IAV infections, thereby reducing the occurrence of long-term complications and enhancing the accuracy and timeliness of clinical decision-making. - Source: PubMed
Publication date: 2026/05/22
Li JunxiangYang YuxiaYue ZiweiZhang Ruijie