CymaxTM Human IL-8 ELISA Kit
- Known as:
- CymaxTM Human Interleukin-8 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- LF-EK0262
- Product Quantity:
- 1
- Category:
- Elisa Kits
- Supplier:
- Abfron
- Gene target:
- CymaxTM Human IL-8 ELISA Kit
Related genes to: CymaxTM Human IL-8 ELISA Kit
- Gene:
- CXCL8 NIH gene
- Name:
- C-X-C motif chemokine ligand 8
- Previous symbol:
- IL8
- Synonyms:
- SCYB8, LUCT, LECT, MDNCF, TSG-1, IL-8, NAP-1, 3-10C, MONAP, AMCF-I, LYNAP, NAF, b-ENAP, GCP-1, K60, GCP1, NAP1
- Chromosome:
- 4q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2016-10-05
- Gene:
- CXCR1 NIH gene
- Name:
- C-X-C motif chemokine receptor 1
- Previous symbol:
- CMKAR1, IL8RA
- Synonyms:
- CKR-1, CDw128a, CD181
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-09
- Date modifiied:
- 2016-03-14
- Gene:
- CXCR2 NIH gene
- Name:
- C-X-C motif chemokine receptor 2
- Previous symbol:
- IL8RB
- Synonyms:
- CMKAR2, CD182
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-19
- Date modifiied:
- 2016-03-14
- Gene:
- CXCR2P1 NIH gene
- Name:
- C-X-C motif chemokine receptor 2 pseudogene 1
- Previous symbol:
- IL8RBP, CXCR2P
- Synonyms:
- -
- Chromosome:
- 2q35
- Locus Type:
- pseudogene
- Date approved:
- 1992-11-27
- Date modifiied:
- 2016-03-14
Related products to: CymaxTM Human IL-8 ELISA Kit
Related articles to: CymaxTM Human IL-8 ELISA Kit
- Breast cancer (BC) is a highly heterogeneous malignancy, and current treatments often suffer from toxicity, limited selectivity, and high cost. This study aimed to integrate transcriptome-level data, multi-layered network analysis, and drug repositioning strategies to identify candidate diagnostic and prognostic biomarkers for BC and propose potential repositioned drug candidates. - Source: PubMed
Publication date: 2026/07/24
Aydin BusraOkutan Beyza NurSara Fatmanur ElifGulseren GulcihanSinha Raghu - Lnk is an adaptor protein that attenuates cytokine receptor signaling in hematopoietic and immune cells, but its role in the behavior of CD8 T cells within solid tumors is not well defined. Using a murine melanoma model, we compared tumor growth and immune infiltration in Lnk-deficient mice and in wild-type controls and evaluated CD8 T cell trafficking toward chemokine signals produced by melanoma cells. Lnk-deficient mice developed smaller tumors containing greater numbers of intratumoral CD8 cytotoxic T cells. Tumor chemokine profiles, including high levels of interleukin-8 family signals such as CXCL2, were comparable between groups, yet CD8 T cells lacking Lnk showed enhanced migration toward melanoma-derived cues and accumulated more effectively within tumors . Pharmacologic inhibition of CXCR1/2 abolished this migratory advantage. Upon stimulation with interleukin-8 family chemokines, Lnk-deficient CD8 T cells exhibited increased activation of STAT3 and ERK signaling pathways. Moreover, antisense-mediated downregulation of Lnk in wild-type T cells resulted in enhanced accumulation within melanoma tumors following adoptive transfer into wild-type hosts. These findings identify Lnk as a negative regulator of CXCR1/2-dependent trafficking of CD8 T cells in melanoma and suggest that modulating this intracellular checkpoint may improve T cell trafficking into solid tumors and enhance the effectiveness of adoptive cellular immunotherapies. - Source: PubMed
Publication date: 2026/07/01
Derdikman Ofir YaelAswad MiranHayun MichalPechkovsky AntoninaKheshaiboun GhazalGhanayiem NarmeenKhier YasmineZohar YanivOfran YishaiLouria-Hayon Igal - Colorectal cancer (CRC) progression from benign polyps to malignant adenocarcinomas is a complex process involving the abnormal proliferation and differentiation of colon epithelial cells. Colorectal adenomas (CRAs), the precursors to most CRCs, are histologically classified into tubular adenomas (TAs), tubulovillous adenomas (TVAs), and villous adenomas (VAs). Despite new findings, the molecular signatures and pathways specific to each adenoma type remain poorly understood. This study aimed to identify specific biomarkers and pathways associated with the progression of TA, TVA, and VA to CRC. - Source: PubMed
Publication date: 2026/07/28
Kolour Haniye RahimiSarirchi SomayehZamani BaharehDaskar-Abkenar ElaheLooha Mehdi AzizmohammadZafarjafarzadeh NiktaKetabimoghadam PardisParvizi MaryamSadeghi AmirNobili StefaniaFatemi NayeralsadatMojarad Ehsan Nazemalhosseini - Obesity increases the risk of multiple chronic diseases and has become a global health challenge. The gut microbiota influences the physiological and pathological processes associated with simple obesity. Elucidating the interactions between gut microbiota and simple obesity provides valuable insights for the development of effective weight-loss strategies. - Source: PubMed
Publication date: 2026/07/13
Gao YidanZhang HaojieJiang RuipingQin LiyunLv Guoping - This systematic review and meta-analysis aimed to assess whether serum inflammatory markers are associated with Carpal Tunnel Syndrome (CTS), moving beyond the traditional mechanical explanation. Seven observational studies involving a total of 609 adult participants (CTS patients and matched healthy controls) were included. Studies were selected through comprehensive searches of PubMed and Embase databases up to April 2025. Data extraction and quality assessment were independently performed by two reviewers using the Newcastle-Ottawa Scale. Standardized mean differences (SMDs) and 95% confidence intervals were calculated using random-effects meta-analysis. CTS patients exhibited significantly elevated serum levels of CCL2, CCL5, CXCL10, CXCL8, IL-4, VEGF, and TGF-β compared to controls. CCL4 was increased in the fixed-effect model but showed high heterogeneity; however, it was not statistically significant in the random-effects model and demonstrated extreme heterogeneity. No significant or consistent differences were observed for IL-1β, IL-6, IL-9, IL-10, TNF-α, or IFN-α. CTS is associated with a systemic pro-inflammatory and pro-fibrotic profile. CCL2, CCL5, IL-4, VEGF, and TGF-β may serve as promising biomarkers. Further large-scale, standardized studies are needed to validate these findings. - Source: PubMed
Publication date: 2026/07/15
Walaszek IreneuszGiżewska-Kacprzak KajaGrochans SzymonRachubińska KamilaGrochans ElżbietaSkonieczna-Żydecka KarolinaCybulska Anna Maria