Chromosome X Centromere CISH Probe
- Known as:
- Chromosome X Centromere color-generating hybridization Probe
- Catalog number:
- 70-0016
- Product Quantity:
- 400
- Category:
- -
- Supplier:
- Genemed
- Gene target:
- Chromosome Centromere CISH Probe
Related genes to: Chromosome X Centromere CISH Probe
- Gene:
- CISH NIH gene
- Name:
- cytokine inducible SH2 containing protein
- Previous symbol:
- -
- Synonyms:
- CIS, G18, CIS-1, SOCS
- Chromosome:
- 3p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1996-09-23
- Date modifiied:
- 2016-10-05
- Gene:
- SOCS5 NIH gene
- Name:
- suppressor of cytokine signaling 5
- Previous symbol:
- -
- Synonyms:
- KIAA0671, SOCS-5, CIS6, CISH6, Cish5
- Chromosome:
- 2p21
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-13
- Date modifiied:
- 2014-11-19
Related products to: Chromosome X Centromere CISH Probe
(+) Control probe (DNA), biotinylated(+) Control probe (RNA), biotinylated(-) Control probe (DNA), biotinylated(-) Control probe (RNA), biotinylated1 MATAL PROBE Tip1 metal probe tip (marked as 19-160-03)1 PLASTIC PROBE TIP1,1'-Dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine perchlorate, Red fluorescent membrane probe, 10mg1,1'-Dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine perchlorate, Red fluorescent membrane probe, 10mg1,1'-Dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine iodide, DiR, A lipophilic near-IR (NIR) fluorescent membrane probe used for labeling cells f1,1'-Dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine iodide, DiR, A lipophilic near-IR (NIR) fluorescent membrane probe used for labeling cells for long term analysis, 25mg1,1'_Dioctadecyl_3,3,3',3'_tetramethylindodicarbocyanine perchlorate, Red fluorescent membrane probe, 10mg1-[4-(Dimethylamino)phenyl]-6-phenylhexatriene (DMA-DPH), Fluorescent probe of lipid bilayer structure and dynamics, 100mg1-[4-(Dimethylamino)phenyl]-6-phenylhexatriene (DMA-DPH), Fluorescent probe of lipid bilayer structure and dynamics, 100mg10-Octadecylacridine orange bromide, Fluorescent Membrane Probe, 20 mg Related articles to: Chromosome X Centromere CISH Probe
- To investigate the response of the suppressor of the cytokine signaling (socs) gene family in rainbow trout following exposure to microplastics, this study conducted a bioinformatics analysis of the socs gene family using rainbow trout genome data, complemented by experiments involving microplastic exposure and gene expression detection. - Source: PubMed
Publication date: 2025/05/22
Ma FangWang WenliDong JiaxuanZhou XiangjunLin ZhiyunZheng PanNian XiajiaoDong Lili - Hepatocellular carcinoma (HCC) is a prevalent malignancy with a high mortality rate worldwide. Suppressor of cytokine signaling (SOCS) family members play important roles in the proliferation, metabolism, and immunity of HCC cells by regulating cytokines and growth factors. However, it remains uncertain whether the level of SOCS family members can affect the prognosis of HCC patients. - Source: PubMed
Dong ZhitaoDai BinghuaWu RuiFang KunpengSui ChengjunGeng LiYang Jiamei - Suppressor of cytokine signalling (SOCS) proteins bind to certain cytokine receptors, Janus kinases and signalling molecules to regulate signalling pathways, thus controlling immune and inflammatory responses. Dysregulated expression of various types of SOCS molecules was indicated in multiple types of allergic diseases. SOCS1, SOCS2, SOCS3, SOCS5, and cytokine-inducible SH2 domain protein (CISH) can differentially exert anti-allergic impacts through different mechanisms, such as suppressing Th2 cell development and activation, reducing eosinophilia, decreasing IgE production, repressing production of pro-allergic chemokines, promoting Treg cell differentiation and activation, suppressing Th17 cell differentiation and activation, increasing anti-allergic Th1 responses, inhibiting M2 macrophage polarization, modulating survival and development of mast cells, reducing pro-allergic activity of keratinocytes, and suppressing pulmonary fibrosis. Although some anti-allergic effects were attributed to SOCS3, it can perform pro-allergic impacts through several pathways, such as promoting Th2 cell development and activation, supporting eosinophilia, boosting pro-allergic activity of eosinophils, increasing IgE production, enhancing the expression of the pro-allergic chemokine receptor, reducing Treg cell differentiation, increasing pro-allergic Th9 responses, as well as supporting mucus secretion and collagen deposition. In this review, we discuss the contrasting roles of SOCS proteins in contexts of allergic disorders to provide new insights regarding the pathophysiology of these diseases and possibly explore SOCS proteins as potential therapeutic targets for alleviating allergies. - Source: PubMed
Publication date: 2023/08/28
Jafarzadeh AbdollahChauhan PrashantNemati MaryamJafarzadeh SaraYoshimura Akihiko - Human respiratory syncytial virus (HRSV) and human metapneumovirus (HMPV) are leading causes of upper and lower respiratory tract infections in non-immunocompetent subjects, yet the mechanisms by which they induce their pathogenicity differ significantly and remain elusive. In this study we aimed at identifying the gene interaction networks between the HRSV, HMPV respiratory pathogens and their host along with the different cell-signaling pathways associated with the above interactomes. - Source: PubMed
Publication date: 2020/01/25
Rouka ErasmiaHatzoglou ChrissiGourgoulianis Konstantinos IZarogiannis Sotirios G - Avian leukosis virus subgroup J (ALV-J) infection can cause tumors and immunosuppression in infected chickens. Macrophages play a crucial role in host defense against invading pathogens. In the present study, whole transcriptome analysis was performed to analyze the host factors including genes, microRNA (miRNA), long non-coding RNA (lncRNA) and their regulatory network in chicken primary monocyte-derived macrophages (MDMs). In total, 128 differentially expressed (DE) lncRNAs and 15 DE miRNAs were identified in MDMs at 3 h post infection (hpi), and 30 DE lncRNAs and 8 DE miRNAs were identified in MDMs at 36 hpi during ALV-J infection. We further constructed the DE lncRNAs-mRNAs, miRNA-mRNAs and lncRNAs-miRNA-mRNAs interaction networks. The results suggested that DE lncRNAs and miRNAs are involved in the regulation of CCND3 and SOCS5 in Jak-STAT signaling pathway via ceRNA network in ALV-J-infected MDMs at 3 hpi. In addition, lncRNAs including XLOC_672329, ALDBGALG0000001429, XLOC_016500 and ALDBGALG0000000253 cis-regulating CH25H, CISH, IL-1β and CD80 respectively in MDMs at 3 hpi participated in host antiviral responses. Our findings give a comprehensive view of the connection between non-coding RNA and ALV-J in chicken primary macrophages, and provide an excellent resource for further studies of epigenetic effects on ALV-J disease resistance breeding as well as immune system and genomic researches. - Source: PubMed
Publication date: 2019/06/11
Dai ManmanFeng MinXie TingtingZhang Xiquan